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Topic: Clinical Characteristics and Health Care Setting
April 22, 2021
High-Dimensional Characterization of Post-Acute Sequalae of COVID-19
COVID-19 patients who survived beyond the first 30 days of illness (n>73,000) had a 1.6-fold increased risk of death compared those who did not have COVID-19 and were not hospitalized (n>4.9 million), according to analysis of databases from the Department of Veterans Affairs. The cohort study also examined 6-month incident sequelae and found that COVID-19…
April 21, 2021
COVID-19 Associated Mortality and Cardiovascular Disease Outcomes among US Women Veterans
Mortality risk among women veterans who tested positive for SARS-CoV-2 was 4 times that of women veterans who tested negative (HR = 3.8) but women who tested positive had lower risk of cardiovascular events (OR = 0.8) and developing new heart disease conditions within 60 days (OR = 0.7), according to a retrospective analysis of national…
Clinical and Demographic Risk Factors for COVID-19 during Delivery Hospitalizations in New York City
Only 27.9% (22 of 79) pregnant individuals with COVID admitted to two New York City hospitals had symptoms consistent with COVID between March 22 and April 18, 2020. Patients with COVID-19 were slightly less likely to have a vaginal delivery (55.2 vs. 51.9%) and had a longer postpartum length of stay with cesarean delivery (2.00…
Post-Acute COVID-19 Outcomes in Children with Mild and Asymptomatic Disease
A multicenter cohort study across Europe conducted among children ≤18 years diagnosed with SARS-CoV-2 infection at a tertiary care hospital found that significant risk factors for ICU admission were age <1 month (OR = 5.1), male sex (OR = 2.1), pre-existing medical conditions (OR = 3.3), and presence of lower respiratory tract infection signs or…
Post-COVID-19 Syndrome in Outpatients a Cohort Study
[Pre-print, not peer-reviewed] In a prospective cohort of symptomatic outpatients undergoing SARS-CoV-2 PCR testing in Switzerland (n= 507), 53% of patients with SARS-CoV-2 infection reported persistent symptoms between 3 and 10 months after diagnosis compared to 37% of patients who tested negative. About 20% of patients who tested positive consulted a physician for persistent symptoms,…
April 20, 2021
Multisystem Inflammatory Syndrome in Infants <12 Months of Age, United States, May 2020–January 2021
A total of 83 of 85 (98%) of infants aged <12 months with multisystem inflammatory syndrome (MIS-C) tested positive for SARS-CoV-2 by either PCR or serology, according to data from a US surveillance system from May 2020 to January 2021. Rash, diarrhea, and vomiting were the most common reported symptoms and the median time from…
Symptoms, Pulmonary Function and Functional Capacity Four Months after COVID-19
Fatigue and shortness of breath with exertion were present four months after infection in approximately 70% of COVID-19 survivors, according to a prospective study of hospitalized COVID-19 patients in Ottawa, Canada (n=25). Among non-hospitalized survivors (n=38), fatigue and exertional breathlessness persisted in 71% and 55%, respectively. At follow-up, forced vital capacity, total lung capacity, peak…
April 19, 2021
Clinical Characteristics of False Negative SARS-CoV-2 Test Results Amongst Hospitalized Patients
False negative SARS-CoV-2 RT-PCR results, defined as an initial negative test followed by a positive test within seven days, were associated with loss of taste or smell (aOR = 8.4), having a SARS-CoV-2-positive contact (aOR = 10.5), and having an elevated lactate dehydrogenase level (aOR = 3.3) compared to true negative results. Among 1,009 SARS-CoV-2 test…
COVID-19 Vaccination Preparedness Policies in U.S. Hospitals
A survey of US infectious disease physicians conducted between December 10, 2020 and January 2, 2021 found that 571 respondents (95%) reported that their facilities had a plan for determining which healthcare personnel (HCP) would be vaccinated first, with most prioritizing by unit (n = 226, 40%), job title or type of work (n =…
April 15, 2021
Mother–Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes
Seven percent (5 of 75) infants born to women with a positive SARS-CoV-2 PCR test at any stage of gestation until 72 hours after birth had at least one positive PCR test during the first week of life, in an urban safety-net hospital in Boston. All infants had clinical courses expected for their gestational age. Sabharwal…
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