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Topic: Clinical Characteristics and Health Care Setting
February 13, 2020
Caution on Kidney Dysfunctions of 2019-nCoV Patients
Authors report on a case study of 59 COVID-19 patients tracking kidney function. A prior study of SARS-CoV patients found that acute renal impairment was uncommon but associated with high case fatality. Preliminary evidence indicates elevated risk of kidney impairment among COVID-19 patients. They recommend vigilant monitoring of kidney function among these patients to facilitate…
ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019 2019-nCoV Infection
Clinical data from three previous studies on COVID-19 patients were reviewed for reports of abnormal renal function or kidney damage. Around 10% of patients had abnormal renal function. The 2019-nCoV virus is known to bind to ACE2 cell receptors, and researchers have determined previously that ACE2 cell receptor expression is relatively higher in kidney cells…
Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan
Researchers evaluate 8,274 people with Wuhan close contacts who were tested for 2019-nCoV, of whom 33.2% had been infected. For 3% of cases (232) diagnosis was not definitive (only one target gene was positive out of two). The results of secondary testing are described along with recommendations for how to handle cases who test positive…
February 12, 2020
Epidemiological and Clinical Characteristics of 17 Hospitalized Patients with 2019 Novel Coronavirus Infections Outside Wuhan, China
A case series of 17 COVID-2019 cases from Dazhou, China is described. In comparing discharged and non-discharged patients, the authors find that younger age and higher lymphocytes and monocyte levels may be factors in faster recover. Li J, et al (Feb 12, 2020) Epidemiological and Clinical Characteristics of 17 Hospitalized Patients with 2019 Novel Coronavirus…
On the use of corticosteroids for 2019-nCoV pneumonia
Shang, et al. respond to an earlier article by Russell, et al. on clinical evidence of corticosteroid therapy in severe coronavirus infections. Shang, et al. describe the potential for selection bias and confounding in observational studies, given that usually only critically ill patients are treated with corticosteroid therapy. They further note that four references in…
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records
A case series of nine pregnant women with COVID-2019 provides a description of clinical characteristics and initial information on risk of vertical transmission. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Seven patients presented with a fever; four, with cough; three, myalgia; and two, sore throat or malaise….
February 10, 2020
Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia
Researchers developed two 1-step real-time RT PCR assays for the Sarbecovirus subgenus to account for potential genetic diversity of the 2019-nCoV circulating in humans. Assays were tested on respiratory samples and results are promising. Further testing is needed. Lo and Chiu offer some commentary and critique of this earlier report and opportunities for further testing. …
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
Following WHO rules for guideline development, this team developed rapid advice guidelines for 2019-nCoV that include epidemiologic characteristics along with recommendations for disease screening and population prevention, diagnosis, treatment and control, nosocomial infection prevention and control, and nursing. This rich tool includes some specific information from Zhongnan Hospital of Wuhan University. Jin et al. (Feb…
Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents
Authors conducted a literature review to determine the ability of coronaviruses to persist on inanimate objects, with potential applications for the current 2019-nCoV outbreak. Both SARS and MERS coronaviruses can persist on inanimate surfaces (fomites) for up to 9 days. They can be inactivated effectively by disinfection procedures with 62-71% ethanol, 0.5% hydrogen peroxide, or…
A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units
A Chinese team provides recommendations for addressing 2019-nCoV preparedness and response in neonatology intensive care units based on prior experiences with coronavirus outbreaks. Wang et al. (Feb 7, 2020). A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units. The Lancet. https://doi.org/10.1016/S2352-4642(20)30040-7
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