Alliance for Pandemic Preparedness

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Topic: Transmission


April 5, 2021

SARS-CoV-2 Infection Is Asymptomatic in Nearly Half of Adults with Robust Anti-Spike Protein Receptor-Binding Domain Antibody Response

In a study of 4996 participants (aged 18–82 years, 34.5% men) from Greece with plasma antibodies against SARS-CoV-2 nucleocapsid protein between June and November 2020, 49% of seropositive cases (39/79) reported no history of SARS-CoV-2 infection-related clinical symptoms. The majority of SARS-CoV-2 asymptomatic infections were “unsuspected” cases (26/39) who had no known contact with a…


Outbreak of COVID-19 and Interventions in a Large Jail — Cook County, IL, United States, 2020

From March 1–April 30, 2020, 907 symptomatic and asymptomatic cases of SARS-CoV-2 infection were detected among detained persons (n = 628) and staff (n = 279) in a large jail in Chicago, representing an attributable risk of 13%. Of 1,256 detained persons tested for SARS-CoV-2, 628 (50%) were positive, among whom 479 (76%) were symptomatic. Early interventions included enhanced…


Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event — Illinois, February 2021

Forty-six cases of COVID-19 were linked to an opening event for an indoor bar (accommodates ~100 persons) in rural Illinois in February 2021 (26 cases among patrons, 3 among staff, and 17 secondary cases). Among secondary cases, 12 occurred in eight households with children, two on a school sports team, and three in a long-term…


April 2, 2021

An Investigation into the Rates of Transmission of SARS-CoV-2 during the First 6 Weeks of the 2020–2021 Academic Year in Primary and Post-Primary Schools in Cork and Kerry, Ireland

The overall incidence of SARS-CoV-2 in-school transmission was 4% during the first 6 weeks of the 2020-2021 academic year in primary and post-primary schools located in Cork and Kerry counties in southwest Ireland, according to government health records. Positivity among students and staff were 3% and 7%, respectively. For roughly every week spent by an…


The Impact of the Non-Essential Business Closure Policy on Covid-19 Infection Rates

Workers designated as having essential jobs had an estimated 55% higher likelihood of SARS-CoV-2 infection compared to those with non-essential jobs in Pennsylvania from February to June 2020, according to a difference-in-differences model based on medical claims data. Household transmission was also estimated to be higher among essential workers. Dependents and roommates cohabiting with an…


Rapid Spread of SARS-CoV-2 in a State Prison After Introduction by Newly Transferred Incarcerated Persons — Wisconsin, August 14–October 22, 2020

In a Wisconsin state medium-security prison, 79% of the incarcerated population and 3% of staff members contracted SARS-CoV-2 in a span of 8 weeks after the prison received six newly transferred persons who were not identified to be SARS-CoV-2 positive at the time of intake. On August 13 the transferred persons were quarantined with other…


March 31, 2021

Increased Transmissibility of the B.1.1.7 SARS-CoV-2 Variant Evidence from Contact Tracing Data in Oslo January to February 2021

[Pre-print, not peer-reviewed] Within households in Norway, the secondary attack rate of the SARS-CoV-2 B.1.1.7 lineage was 60% higher than that of other variants. The study used contact tracing data from 415 index cases and 2,718 of their close contacts from January 4 to February 28, 2021 to estimate transmissibility and found an absolute increase…


March 30, 2021

Successful Control of an Onboard COVID-19 Outbreak Using the Cruise Ship as a Quarantine Facility, Western Australia

Onboard quarantine measures to reduce the risk of a SARS-CoV-2 outbreak among crew members of the cruise ship MS Artania led to no symptomatic infections among crew members after completion of quarantine, despite an attack rate of 6% (30 of 503) before quarantine and 5% (21 of 441) during quarantine on board. The outbreak occurred…


March 29, 2021

Single Dose of a MRNA SARS-CoV-2 Vaccine Is Associated with Lower Nasopharyngeal Viral Load among Nursing Home Residents with Asymptomatic COVID-19

Among nursing home residents in Pennsylvania with asymptomatic COVID-19 diagnosed through twice-weekly surveillance testing (n=10), residents who received a single dose of the BNT162b2 (Pfizer-BioNTech) vaccine had significantly lower nasopharyngeal viral load (-2.4 mean log10 lower) than unvaccinated residents. The authors note their results suggest a single dose may start to reduce transmission among nursing home…


Comparison of Cough Particle Exposure for Indoor Commercial and Aircraft Cabin Spaces

[Pre-print, not peer-reviewed] Computational fluid dynamics (CFD) simulations from Boeing showed that in an airplane cabin (Boeing 737), 80% of particles from a coughing person were removed 5-12 times faster than from a similar indoor commercial space, which resulted in 7 times less particulate mass inhaled.  Davis et al. (Mar 26, 2021). Comparison of Cough Particle…



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