Alliance for Pandemic Preparedness

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Topic: Transmission


January 31, 2020

Transmission dynamics of 2019 novel coronavirus (2019-nCoV)

Epidemiologic characteristics of confirmed cases of 2019-nCoV in China up to January 23 were used to produce time-dependent reproductive numbers. Findings suggest that the rate at which secondary cases are appearing may have been decreasing over the last few weeks. Liu et al. (Jan 26, 2020). Transmission dynamics of 2019 novel coronavirus (2019-nCoV). Pre-Print. https://www.biorxiv.org/content/10.1101/2020.01.25.919787v1 


Beware of asymptomatic transmission: Study on 2019-nCoV prevention and control measures based on extended SEIR model

Researchers constructed a model to assess the effectiveness of three control measures (isolation of ill persons, restricted human mobility, and improving treatment) at reducing the spread of the outbreak. Findings suggest that public health interventions that restrict movement remain necessary, particularly if asymptomatic transmission is widespread (which has yet to be determined). Shao and Shan…


The Novel Coronavirus Originating in Wuhan, China Challenges for Global Health Governance

In this commentary, authors discuss the use of a cordon sanitaire (cordoned off area where movement is restricted) in Wuhan and suggestions for slowing the spread of the outbreak, including the issues associated with involuntary social isolation.  Phelan et al. (Jan 30, 2020). The Novel Coronavirus Originating in Wuhan, China Challenges for Global Health Governance….


Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany

On 1/28 potential asymptomatic transmission of 2019-nCoV was identified in Germany. A new report indicates a second person was infected by the same asymptomatic traveler from China. The virus seems to have been transmitted during the index patient’s incubation period. Once symptoms did develop, the index patient experiences brief and nonspecific symptoms. High sputum viral…


January 30, 2020

Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020

The epidemiologic characteristics of cases of 2019-nCoV identified as of Jan 22, 2020 by health authorities are described. Graphics and tables are valuable resources worth reviewing. Case fatality among hospitalized patients was estimated at 14% (95% CI: 3.9–32%), though caution should be used in interpreting this as duration of hospitalization prior to death can be…


Potential of large ‘first generation’ human-to-human transmission of 2019-nCoV

A Wuhan-based research team studied the genetic diversity, origin, and evolution of the 2019-nCoV outbreak in china and Thailand (Bangkok) using likelihood-mapping and phylogenetic analysis. They estimate that the common ancestor of the virus originated in Wuhan on November 9, 2019 (95% CI: Sep 25-Dec 19. 2019). There is some evidence that super-spreaders may have…


January 29, 2020

Germany confirms human transmission of coronavirus

Limited information is available about potential person-to-person transmission in Germany. A person who had not travelled to China was diagnosed with 2019-nCoV after attending a company training with a colleague from China. The Chinese colleague had recently been visited by family who came from Wuhan. It appears that transmission between the traveler and the German…


January 28, 2020

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

A hospital-based case study in Shenzhen, Guangdong province among six family members who travelled to Wuhan provides further evidence of person-to-person transmission. Fuk-Woo Chan et al. (Jan 24 2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet. https://doi.org/10.1016/S0140-6736(20)30154-9


Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam

A new case of illness was identified in a 27 year-old male from Vietnam who had not travelled to China. He had, however, spent three days with his parents in a shared hotel room after their return from travel in Wuhan, China. The father was diagnosed with 2019 n-CoV as well. Incubation period was estimated…



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