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Topic: Vaccines and Immunity
June 15, 2021
Safety and Immunogenicity of a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients: A Case Series
In solid organ transplant recipients, a third dose of a COVID-19 vaccine was not able to elicit detectable anti-SARS-CoV-2 antibody responses in 53% of participants in a cohort study (n=30). Prior to receiving the third dose, 80% of patients did not have detectable antibody responses. All patients were fully vaccinated with mRNA vaccines (57% Pfizer-BioNTech,…
Naturally Enhanced Neutralizing Breadth against SARS-CoV-2 One Year after Infection
82% of individuals recovered from COVID-19 maintained RBD-specific IgG titers, RBD-specific B cells, and neutralizing activities between 6-12 months after infection, according to analysis of 68 recovered individuals, suggesting long-lived immunity to COVID-19. In 41% of participants who received an mRNA vaccine, vaccination increased IgG responses by 30-fold, neutralizing activity by 50-fold, and circulating number…
Allergic Symptoms after mRNA COVID-19 Vaccination and Risk of Incomplete Vaccination
Self-reported allergic symptoms following the first dose of a COVID-19 mRNA vaccine was associated with a 5-fold increase in odds of not completing the second dose after adjusting for demographics, vaccine manufacturer, wave of vaccine eligibility, and other confounders in a prospective cohort of healthcare employees in Boston. Among 61,057 employees who received a first…
COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy — Eight Integrated Health Care Organizations, United States, December 14, 2020–May 8, 2021
As of May 8, 2021, 16% (22,197 of 135,968) of pregnant women identified in CDC’s Vaccine Safety Datalink, which includes integrated health systems from 7 US states, have received ≥1 dose of a COVID-19 vaccine during pregnancy. Of those initiating vaccination 68% have completed either a 1- or 2-dose series. Vaccination during pregnancy was highest…
Young Infants Exhibit Robust Functional Antibody Responses and Restrained IFN-γ Production to SARS-CoV-2
A study evaluating the immune responses in four infants with mild COVID-19 (median age 7 weeks old) found that compared to their parents who also had COVID-19 (n=8) and a cohort of adult controls with prior COVID-19 (n=10), infants had higher anti-SARS-CoV-2 IgG antibody levels in both sera and saliva and exhibited more robust serum…
SARS-CoV-2 Delta VOC in Scotland: Demographics, Risk of Hospital Admission, and Vaccine Effectiveness
SARS-CoV-2 infections caused by the B.1.617.2 (Delta) variant of concern were at increased risk of hospitalization (HR=1.9) compared to the B.1.1.7 (Alpha) variant after adjusting for demographics, temporal trends, and comorbidities, according to an analysis of 19,543 confirmed infections and 377 hospitalizations in Scotland from April 1 to June 6, 2021. Considering the whole population…
June 14, 2021
Perceptions and Concerns Regarding COVID-19 Vaccination in a Military Base Population
Younger age and medical occupation were independent predictors of vaccine hesitancy according to results from a survey of individuals working on a military base in Ohio, administered between November 2020 and January 2021. Among 816 survey respondents, 185 (23%) self-identified as vaccine hesitant. The vaccine hesitant group reported more concern about short-term side effects (43%…
The SARS-CoV-2 MRNA Vaccine Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity
A study of 24 breakthrough SARS-CoV-2 infections among fully vaccinated US Military Health System beneficiaries indicated that most infections (67%) occurred among those without comorbid conditions, 57% reported close contact with a COVID-19 case in the past month, and no case of breakthrough infection resulted in hospitalization. Sequencing from 10 of 13 qPCR-positive specimens indicated…
Community-Level Evidence for SARS-CoV-2 Vaccine Protection of Unvaccinated Individuals
A study of SARS-CoV-2 vaccination in 177 different communities in Israel indicated that for every 20 percentage point increase in the proportion of individuals who were vaccinated in a given population, the positive test fraction for the unvaccinated population decreased approximately two-fold, which the authors suggest shows that vaccination provides indirect protection to unvaccinated individuals. Findings…
Impact of Baseline SARS-CoV-2 Antibody Status on Syndromic Surveillance and the Risk of Subsequent Covid-19 – a Prospective Multicentre Cohort Study
[Pre-print, not peer-reviewed] The presence of SARS-CoV-2 anti-nucleocapsid antibodies at baseline was associated with almost 80% protection against SARS-CoV-2 re-infection for a period of at least eight months, according to a study of healthcare workers (HCW) in Switzerland. Among 4,818 participants, 144 (3%) were seropositive at baseline. Among 2,713 participants with ≥1 SARS-CoV-2 test during…
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