Result for
Topic: Vaccines and Immunity
May 18, 2021
The Effectiveness of the TWO-DOSE BNT162b2 Vaccine: Analysis of Real-World Data
The Pfizer-BioNTech vaccine was 90% effective in preventing any SARS-CoV-2 infection when comparing incidence of infection between 7-27 days after the second dose (protection period) vs 1-7 days after the first dose (reference period). The findings are based on a cohort belonging to a large health provider in Israel (n=1.2 million), of which 74% had…
May 17, 2021
The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine in Adolescents Aged 12–15 Years — United States, May 2021
On May 12th, 2021, the Advisory Committee on Immunization Practices (ACIP) made an interim recommendation for the use of the Pfizer-BioNTech vaccine among adolescents aged 12-15, following the expansion of the FDA Emergency Use Authorization age eligibility to include this age group. The ACIP considered evidence from a systematic review of published and unpublished evidence…
Seroconversion Rates Following COVID-19 Vaccination amongst Patients with Malignant Disease- the Impact of Diagnosis and Cancer-Directed Therapies
[Pre-print, not peer-reviewed] Among patients with cancer (n = 201) who were fully vaccinated with the Pfizer-BioNTech, Moderna, or Johnson & Johnson/Janssen vaccines, the majority (94%) showed seroconversion for anti-spike protein IgG. Lower seroconversion frequencies were observed for patients with hematological malignancies (85%), particularly recipients of anti-CD20 therapies (70%) and stem cell transplantation (74%), compared…
The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-Elicited and Therapeutic Monoclonal Antibodies
[Pre-print, not peer-reviewed] The SARS-CoV-2 B.1.617 and B.1.618 strains currently circulating in India were found to have specific spike protein mutations (B.1.617 = L452R/E484Q/D614G/P681R, B.1.618 = Δ145-146/E484K/D614G) that were somewhat resistant to neutralization by sera from convalescent individuals, vaccine-elicited antibodies, and therapeutic monoclonal antibodies; but not enough to suggest that current vaccines will not be…
Cellular Immunity Predominates over Humoral Immunity after the First Dose of COVID-19 Vaccines in Solid Organ Transplant Recipients
[Pre-print, not peer-reviewed] Among solid organ transplant recipients (n = 40) and age-matched controls (n = 70), antibodies were detected in only 5% of transplant recipients versus 80% of controls, though specific CD4 and/or CD8 T-cells were more frequently found in both transplant recipients (24%) and controls (84%). IgG and neutralization activity were also higher…
Risk of SARS-CoV-2 Reinfection in a University Student Population
The risk of SARS-CoV-2 reinfection among college students with prior infection was 2.2% (n = 16,101, 2,021 with and 14,080 without previous infection), while estimated protection from previous infection was 84% among students tested in fall 2020 and spring 2021 semesters at a large university in South Carolina. All students with access to main campus…
Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel — 33 U.S. Sites, January–March 2021
Among US healthcare personnel, one dose of either the Pfizer-BioNTech or Moderna vaccines was 82% effective against symptomatic COVID-19, and 2 doses were 94% effective. Interim results from a test-negative case-control study conducted in 25 states and enrolling 623 case-patients and 1,220 controls as of March 18, 2021 indicate that vaccine effectiveness is similar to…
Durability of MRNA-1273-Induced Antibodies against SARS-CoV-2 Variants
[Pre-print, not peer-reviewed] An analysis of sera from participants in the Moderna vaccine trial (n=24) found that most individuals maintained both binding and functional antibodies against the B.1.1.7, B.1.351, P.1, B.1.429, and B.1.526 SARs-CoV-2 variants for 6 months, although at lower levels relative to wildtype and D614G. The B.1.1.7 lineage had little impact on antibody…
Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca Vaccines on Covid-19 Related Symptoms, Hospital Admissions, and Mortality in Older Adults in England: Test Negative Case-Control Study
A case-control study of the effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines among adults aged 70 and older (n = 156,930) found that one dose of either vaccine was about 80% effective at preventing hospital admission with COVID-19, and a single dose of Pfizer-BioNTech was 85% effective at preventing death (follow-up was insufficient to assess…
Anti-SARS-CoV-2 Antibodies Persist for up to 13 Months and Reduce Risk of Reinfection
[Pre-print, not peer-reviewed] A longitudinal study of antibody responses among healthcare workers in France, 916 of whom had not had COVID-19 and 393 who were convalescent, found that almost all convalescent individuals (96%) had persistence of anti-S IgG antibodies one year after infection. From month 1 until months 7-9 after infection, SARS-CoV-2 antibodies decreased, with…
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