Small Heat-shock ProteinssHSPs are a class of diverse chaperone proteins that act as the cell's "first responders" during conditions of high intracellular stress. The ten human sHSPs are refractory to conventional structural techniques. The Klevit lab has used a hybrid approach incorporating solid-state NMR, SAXS, and EM to generate the first atomic-level model of a 24-subunit oligomer of human aB-crystallin.
BRCA1/BARD1 HeterodimerBRCA1/BARD1, the breast cancer associated protein heterodimer. The Klevit lab is recognized for being the first to solve the solution NMR structure of this medically relevant protein complex.
Ubiquitination Pathway Protein ubiquitination is involved in the regulation of every cellular process. The modification is carried out by a trio of enzymes known as E1, E2, and E3. In humans, there are over thirty E2s and more than 600 E3s. We are currently studying an array of human E2s and E3s, using approaches that range from structural biology to genetics in model organisms.
Lab Meeting Schedule
Lab meetings for Winter quarter 2013 are currently scheduled for Thursdays at 11am in room K450. The first meeting at the new time will be held on January 24th, 2013. Be sure to bring snacks!
The next Seattle Ubiquitin Research Group meeting will be held on Thursday January 17th, 2017. This meeting will be held in Bioengineering N130 at 5:30 pm. Please see the flier for more details.
Having difficulty locating a publication from our lab? The PubMed database is an excellent tool used for locating and downloading all of the papers submitted by our group.
Interested in one of our published plasmids? Please look through our Addgene database before contacting us directly. If you still can't find what you're looking for, then contact us via email.