The Klevit group is dedicated to furthering the human understanding on the complex nature of protein-protein interactions involved in protein quality control and repair. Deleterious mutations in key participants of these intracellular pathways frequently result in the manifestation of cancer, cataracts, myopathy, and many other forms of chronic disease. Members of the Klevit lab are experienced in various biochemical structural techniques, including Circular Dichroism (CD), Solution/Solid-State Nuclear Magnetic Resonance (NMR), Small-Angle X-ray Scattering (SAX), and Analytical Ultra-Centrifugation (AUC). Technical and engineering expertise is also prevalent amongst members of the lab, with many individuals sharing a strong background in computer science and technology.
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Rachel E. Klevit Principle Investigator Professor of Biochemistry Professor of Chemistry klevit@u.washington.edu |
NMR; protein structure, protein/protein, protein/DNA interactions. |
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Peter Brzovic Research Faculty brzovic@uw.edu |
BRCA1-dependent ubiquitination, NMR |
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Ponni Rajagopal Research Scientist ponjan@uw.edu |
Small heat shock protein structure and function. Understanding the structure and mechanism of the deletarious Alpha-B Crystallin mutant, R120G. |
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Joel Rosenbaum Post-doc joelcr@uw.edu | Alpha-A crystallin, a small heat shock protein abundant in the eye lens. |
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Jonathan Pruneda Ph.D Candidate jpruneda@u.washington.edu | Use of NMR and SAXS to study protein-protein interactions involved in the final stages of ubiquitin transfer. |
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Vinayak Vittal Ph.D Candidate vvittal@uw.edu | Protein-protein interactions involving BARD1, the heterodimeric partner of BRCA1. |
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Scott Delbecq Ph.D Candidate delbes@u.washington.edu | AlphaB-Crystallin, a small heat-shock protein which acts as a molecular chaperone. |
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Katja Dove Ph.D Candidate kkd5@uw.edu | Structure-function relationship of E2/E3 interactions to understand the underlying mechanisms utilized by specific classes of E3s. |
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Amanda Clouser Ph.D Student aclouser@uw.edu | Hsp27 phosphorylation and pH dependence. |
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Andrew Borst Research Scientist I Lab Technician borsta2@uw.edu | Small Heat-shock protein chaperone activity and quaternary structure organization. |
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Christine Caputo Laboratory Manager caputoc@gmail.com | Interests: Global/Public Health disease research. Maternal and child health issues. |
