The Klevit group is dedicated to furthering the human understanding on the complex nature of protein-protein interactions involved in protein quality control and repair. Deleterious mutations in key participants of these intracellular pathways frequently result in the manifestation of cancer, cataracts, myopathy, and many other forms of chronic disease. Members of the Klevit lab are experienced in various biochemical structural techniques, including Circular Dichroism (CD), Solution/Solid-State Nuclear Magnetic Resonance (NMR), Small-Angle X-ray Scattering (SAX), and Analytical Ultra-Centrifugation (AUC). Technical and engineering expertise is also prevalent amongst members of the lab, with many individuals sharing a strong background in computer science and technology.

Rachel E. Klevit
Principal Investigator
Professor of Biochemistry
Professor of Chemistry

NMR; protein structure, protein/protein, protein/DNA interactions.

Peter Brzovic
Research Faculty

BRCA1-dependent ubiquitination, NMR

Ponni Rajagopal
Research Scientist

Small heat shock protein structure and function. Understanding the structure and mechanism of the deletarious Alpha-B Crystallin mutant, R120G.

Lisa Tuttle

NMR, protein-protein interactions, transcription regulation, protein structure/dynamics

Mikaela Stewart

Protein function, structure, and dynamics.

Vinayak Vittal
Ph.D Candidate

Protein-protein interactions involving BARD1, the heterodimeric partner of BRCA1.

Scott Delbecq
Ph.D Candidate

AlphaB-Crystallin, a small heat-shock protein which acts as a molecular chaperone.

Katja Dove
Ph.D Candidate

Structure-function relationship of E2/E3 interactions to understand the underlying mechanisms utilized by specific classes of E3s.

Amanda Clouser
Ph.D Student

Hsp27 phosphorylation and pH dependence.

Paul DaRosa
Ph.D Student

Interplay between protein PARsylation and ubiquitination

Matt Cook
Ph.D Student

Interests: ____

Emily Duncan
Research Scientist I
Lab Technician


Hezi Ji
Undergraduate Lab Assistant

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