We are fascinated by the molecules of life. In principle, all of biology can be understood and explained by the interplay among molecules. Among biomolecules, proteins form the largest class and perform the most diverse range of functions. Research in our laboratory is directed towards an understanding of molecular recognition, with an emphasis on protein-protein interactions that play important roles in human disease.
A variety of structural, biochemical, molecular biological, and biophysical techniques are used in the Klevit laboratory, with a major emphasis on high resolution NMR spectroscopy and mass spectrometry. Ongoing projects in the group include the following systems: BRCA1, the breast cancer susceptibility protein; protein ubiquitination in general; human small heat shock proteins alpha-B crystallin and HSP27.