Dr. Caitlin Cain

Biography

Caitlin graduated from Virginia Commonwealth University in 2019 with B.S. degrees in Chemistry and Forensic Science. While there, she fabricated continuous stationary phase gradients for liquid chromatography and studied the effects of coupling gradients in the mobile and stationary phases on peak parameters under the guidance of Dr. Sarah Rutan and Dr. Maryanne Collinson. Following graduation, she moved to the University of Washington to study multidimensional gas chromatography and chemometrics under Dr. Robert Synovec. Caitlin defended her PhD in April of 2024 and will be working on her post-doctoral research in Dr. Bob Kennedy’s lab.

Publications

  1. C. N. Cain, G. S. Ochoa, R. E. Synovec, Enhancing partial least squares modeling of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry data by tile-based variance ranking, J. Chromatogr. A 2023, 1694, 463920. https://doi.org/10.1016/j.chroma.2023.463920
  2. T.J. Trinklein, C.N. Cain, G.S Ochoa, S. Schöneich, L. Mikaliunaite, Recent Advances in GC×GC and Chemometrics to Address Emerging Challenges in Nontargeted Analysis, Anal. Chem. 2023, 95, 264-286.
    https://doi.org/10.1021/acs.analchem.2c04235
  3. Optimization of Parameters for ROI Data Compression for Nontargeted Analyses Using LC–HRMS, S. Schöneich, C.N. Cain, C.E. Freye, R.E. Synovec, Anal. Chem. 2023, 95, 2, 1513–1521.
    https://doi.org/10.1021/acs.analchem.2c04538
  4. P.E. Sudol, G.S. Ochoa, C.N. Cain, R.E. Synovec, Tile-based variance rank initiated-unsupervised sample indexing for comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry, Anal. Chim. Acta 2022, 1209, 339847.
    https://doi.org/10.1016/j.aca.2022.339847
  5. C.N. Cain, T.J. Trinklein, G.S. Ochoa, R.E. Synovec, Tile-based pairwise analysis of GC× GC-TOFMS data to facilitate analyte discovery and mass spectrum purification, Anal. Chem. 2022, 94, 5658-5666.
    https://doi.org/10.1021/acs.analchem.2c0022
  6. L. Mikaliunaite, P.E. Sudol, C.N. Cain, R.E. Synovec,  Baseline correction method for dynamic pressure gradient modulated comprehensive two-dimensional gas chromatography with flame ionization detection. J. Chromatogr. A 2021, 1652, 462358
    https://doi.org/10.1016/j.chroma.2021.462358
  7. C.N. Cain,  P.E. Sudol, K.L Berrier, R.E. Synovec, Development of variance-ranked unsupervised sample indexing for gas chromatography mass spectrometry, Talanta 2021, 122495.
    https://doi.org/10.1016/j.talanta.2021.122495
  8. C.N. Cain, N.J. Haughn, H.J. Purcell, L.C. Marney, R.E. Synovec,  C.T. Thoumsin, S.C. Jackels, K.J. Skogerboe, Analytical Determination of the Severity of Potato Taste Defect in Roasted East African Arabica Coffee, J. Agric. Food Chem. 2021, 69, 2253-2261.
    https://doi.org/10.1021/acs.jafc.1c00605
  9. C.N. Cain, S. Schöneich, R.E. Synovec, Development of an Enhanced Total Ion Current Chromatogram Algorithmn to Improve Untargeted peak Detection, Anal. Chem., 2020, 92, 11365-11373.
    https://doi.org/10.1021/acs.analchem.0c02136
  10. C.N. Cain, A.V. Forzano, S.C. Rutan, M.M. Collinson, Experimental- and Simulation-Based Studies on the Effects of Coupling Stationary and Mobile Phase Gradients. J. Chromatogr. A, 2019, 1602, 237-245.
    https://doi.org/10.1016/j.chroma.2019.05.033
  11. A.V. Forzano, C.N. Cain, S.C. Rutan, M.M Collinson,  In-situ Silanization for the Fabrication of Continuous Stationary Phase Gradients on Particle Packed LC Columns. Anal. Methods, 2019, 11, 3648-3656.
    https://doi.org/10.1039/c9ay00960d
  12. C.N. Cain, A.V. Forzano, S.C. Rutan, M.M. Collinson, Destructive Stationary Phase Gradients for Reversed- Phase/Hydrophilic Interaction Liquid Chromatography. J. Chromatogr. A, 2018, 1570, 82-90.
    https://doi.org/10.1016/j.chroma.2018.07.073

Presentations

Reversed-Phase/Cation Exchange Stationary Phase Gradient for Analysis of Neurotransmitters. Cain, CN; Forzano AV; Rutan, SC; Collinson, MM. The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (PITTCON), Philadelphia, PA. March 19, 2019.

 

Investigation of Increased Chromatographic Resolution through Mobile Phase Gradients Coupled with Stationary Phase Gradients. Cain, CN; Forzano, AV; Rutan, SC; Collinson, MM. 47th International Symposium on High Performance Liquid Separations and Related Technologies, Washington, DC. July 30, 2018.

Destructive Stationary Phase Gradients for Liquid Chromatography. Cain, CN; Forzano, AV; Rutan, SC; Collinson, MM. Advances in Separations Symposium, 254th American Chemical Society National Meeting, Washington, DC. August 23, 2017.

Awards

National Science Foundation Graduate Research Fellowship (2019-2024)