Dr. Tim Trinklein

Tim graduated from the University of Wisconsin-Milwaukee in 2018 with a degree in Chemistry. There, he worked under Prof. Joseph Aldstadt developing flow- and sequential-injection analytical techniques and their hyphenation with low-field NMR spectroscopy for the determination of NPS (new psychoactive substances) in seized forensic samples. Tim moved to Seattle in September of 2018 to pursue graduate studies in the Synovec lab where he is a currently a 5th year. Tim’s interests span fundamental theory, instrumentation, and chemometrics for comprehensive two- and three-dimensional gas chromatography. While not in the lab, Tim enjoys climbing and mountaineering. Tim can be contacted at timtk@uw.edu.

Publications

  1. T.J. Trinklein, C.N. Cain, G.S. Ochoa, S. Schöneich, L. Mikaliunaite and R.E. Synovec, Recent advances in GC×GC and chemometrics to address emerging challenges in nontargeted analysis, Anal. Chem., 2023, 95, 264–286.
    https://doi.org/10.1021/acs.analchem.2c04235
  2. L. Mikaliunaite, T.J. Trinklein, G.S. Ochoa, P.E. Sudol, D.S. Bell, and R.E. Synovec, Valve-based comprehensive two-dimensional gas chromatography with quadrupole mass spectrometry detection using a porous layer open tubular column in the first dimension, J. Chromatogr. Open 2023, 3, 100076.
    https://doi.org/10.1016/j.jcoa.2022.100076
  3. R.C. Halvorsen#, T.J. Trinklein#, C.G. Warren, R.D. Rogan, R.E. Synovec. Optimizing column-to-column retention time alignment in high-speed gas chromatography by combining retention time locking and correlation optimized warping, Talanta 2023, 254, 124173.
    https://doi.org/10.1016/j.talanta.2022.124173
  4. T.J. Trinklein and R.E. Synovec, Simulating comprehensive two-dimensional gas chromatography mass spectrometry data with realistic run-to-run shifting to evaluate the robustness of tile-based Fisher ratio analysis, J. Chromatogr. A, 2022, 1677,463321.
    https://doi.org/10.1016/j.chroma.2022.463321
  5. T.J. Trinklein, Jiaxin Jiang, and Robert E. Synovec, Profiling olefins in gasoline by bromination using GC×GC-TOFMS followed by discovery-based comparative analysis, Anal. Chem. 2022, 94, 9407-9414.
    https://doi.org/10.1021/acs.analchem.2c01549
  6. C.N. Cain, T.J. Trinklein, G.S. Ochoa, R.E. Synovec, Tile-based pairwise analysis of GC×GC-TOFMS data to facilitate analyte discovery and mass spectrum purification, Anal. Chem. 2022, 94, 5658-5666
    https://doi.org/10.1021/acs.analchem.2c00223
  7. G.S. Ochoa. P.E. Sudol. T.J. Trinklein, R.E. Synovec, Class comparison enabled mass spectrum purification for comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry, Talanta 2022, 236, 122844.
    https://doi.org/10.1016/j.talanta.2021.122844
  8. T.J. Trinklein, C.G. Warren, R.E. Synovec, Determination of the signal-to-noise ratio enhancement in comprehensive three-dimensional gas chromatography, Anal. Chem. 2021, 93, 8526–8535.
    https://doi.org/10.1021/acs.analchem.1c01190
  9. TJ. Trinklein, M. Thapa, L.A. Lanphere, J.A. Frost, S.M. Koresch, J.H. Aldstadt. Sequential injection analysis coupled to on-line benchtop proton NMR: Method development and application to the determination of synthetic cathinones in seized drug samples, Talanta 2021, 231, 122355.
    https://doi.org/10.1016/j.talanta.2021.122355
  10. T.J. Trinklein, S. Schöneich, P.E. Sudol, D.V. Gough, R.E. Synovec, Total-transfer comprehensive three-dimensional gas chromatography with time-of-flight mass spectrometry, J. Chromatogr. A 2020, 1634, 461654.
    https://doi.org/10.1016/j.chroma.2020.461654
  11. S. Schöneich#,  T. J. Trinklein#, C.G. Warren, R.E. Synovec, A systematic investigation of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry with dynamic pressure gradient modulation for high peak capacity separations, Anal. Chim. Acta 2020, 1131,  115-124.
    https://doi.org/10.1016/j.aca.2020.08.023
  12. T.J. Trinklein, S.E. Prebihalo, C.G. Warren, G.S. Ochoa, R.E. Synovec, Discovery-based analysis and quantification for comprehensive three-dimensional gas chromatography flame ionization detection, J. Chromatogr. A 2020, 1623, 461190.
    https://doi.org/10.1016/j.chroma.2020.461190
  13. S. Schöneich, D.V. Gough, T. J. Trinklein, R.E. Synovec, Dynamic pressure gradient modulation for comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection, J. Chromatogr. A 2020, 1620, 460982.
    https://doi.org/10.1016/j.chroma.2020.460982
  14. T.J. Trinklein, D.V. Gough, C.G. Warren, G.S. Ochoa, R.E. Synovec, Dynamic pressure gradient modulation for comprehensive two-dimensional gas chromatography, J. Chromatogr. A  2020, 1609, 460488.
    https://doi.org/10.1016/j.chroma.2019.460488

Select Presentations

  1. T.J. Trinklein, R.E. Synovec, “Exploring Total-Transfer Comprehensive Three-Dimensional Gas Chromatography”, 18th International GC×GC Symposium, Virtual, June 2021
  2. Trinklein, T.J., Cain, C.N., Schöneich, S., Mikaliunaite, L., Sudol, P.E., Ocaho, G.S., Synovec, R.E., “Gas chromatography with chemometrics for discovery and process analysis”, Center for Process Analysis and Control (CPAC) Rome Workshop, Virtual, March 2021.
  3. Trinklein, T.J., Schöneich, S., Sudol, P.E., Warren, C.G., Gough, D.V., Synovec, R.E., “Development of a tandem total-transfer modulation comprehensive three-dimensional gas chromatography (GC3) time-of-flight mass spectrometry instrument”, 12th Multidimensional Chromatography Workshop, Virtual, February 2021
  4. Trinklein, T.J., Schöneich, S., Sudol, P.E., Warren, C.G., Gough, D.V., Sudol, P.E., Ochoa, G.S., Synovec, R.E., “Advances in multidimensional gas chromatography instrumentation and chemometric data analysis”, The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (PITTCON), Chicago, IL, March 2020
  5. Trinklein, T.J., Synovec, R.E. “Dynamic pressure gradient modulation for multidimensional gas chromatography: instrumentation and chemometrics”, The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (PITTCON), Chicago, IL, March 2020.
  6. Trinklein, T.J., Sudol, P.E., Synovec, R.E. “Implementing gas chromatography for real-time process analysis”, Center for Process Analysis and Control (CPAC) Summer Meeting, Lake Kachess, WA, July, 2019
  7. Trinklein, T.J., Schöneich, S., Synovec, R.E. “Dynamic pressure gradient modulation for comprehensive two-dimensional gas chromatography”, Pacific Northwest National Laboratory (PNNL), Richland, WA, September, 2019.
  8. Trinklein, T.J., Song, D., Gough, D.V. Synovec, R.E. “Ultrafast comprehensive two-dimensional gas chromatography via pulse valve injection in the negative mode”, Northwest Regional Meeting of the American Chemical Society (NORM), Portland, OR, June, 2019.
  9. Trinklein, T.J., Synovec, R.E. “Defining the optimum pressure ratio in comprehensive two-dimensional gas chromatography with partial modulation”, Center for Process Analysis and Control (CPAC) Spring Institute, Seattle, WA, April, 2019.