Yeast Resource Center | Technology driven by biology.
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Collaborate with the YRC. Click to learn more.

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Learn more about the technology being developed by the YRC.

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Find software developed by the YRC.

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Find research articles published by the YRC.

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The YRC is a NIGMS Biomedical Technology Research Center based at the University of Washington in Seattle. Click to learn more about us.

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Learn more about the technologies being developed by the YRC and how they are being applied to biomedical problems.

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Learn how to collaborate with the YRC–leveraging our technology and expertise in your research.

197

Active Projects

230

Collaborators Since 2011

$38M

Annual NIH Dollars Impacted

727

YRC Publications

New Research
elife-2015-highlight

We are developing technology to produce biosensors based on a ligand-binding domain (LBD) that may, in principle, be applied to any target molecule. The power of this method is illustrated in this paper by development of biosensors for digoxin and progesterone.

Read more in eLIFE or in PubMed Central.

nat-comm-2014-highlight

In this work, we combine the results of protein cross-linking mass spectrometry with iterative structural modelling to determine the molecular architecture of the 10-member Dam1p protein complex in S. cerevisiae. Using this technique, we can model conformational changes resulting from binding with microtubules.

Read more in Nature Communications or in PubMed Central.

Latest Publications

Shan, CM et al. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Elife 5 :. PMID:27648579

The, M et al. (2016) Fast and Accurate Protein False Discovery Rates on Large-Scale Proteomics Data Sets with Percolator 3.0. J. Am. Soc. Mass Spectrom. 27 (11):1719-1727. PMID:27572102

Chatterjee, S et al. (2016) A comprehensive and scalable database search system for metaproteomics. BMC Genomics 17 (1):642. PMID:27528457

Halloran, JT et al. (2016) Dynamic Bayesian Network for Accurate Detection of Peptides from Tandem Mass Spectra. J. Proteome Res. 15 (8):2749-59. PMID:27397138

May, DH et al. (2016) An Alignment-Free "Metapeptide" Strategy for Metaproteomic Characterization of Microbiome Samples Using Shotgun Metagenomic Sequencing. J. Proteome Res. 15 (8):2697-705. PMID:27396978