The National Center for Research Resources' Yeast Resource Center is located at the University of Washington in Seattle, Washington. The mission of the center is to facilitate the identification and characterization of protein complexes in the yeast Saccharomyces cerevisiae. We provide expertise and access to five advanced technologies:

• mass spectrometry
• yeast two-hybrid arrays
• deconvolution fluorescence microscopy
• protein structure prediction
• computational biology

Through collaborations with YRC personnel these critical, but costly, technologies are made available to a large community of researchers throughout the country.

The investigators participating in the YRC include Dr. John Yates and Dr. Mike MacCoss for mass spectrometry, Dr. Stan Fields for two-hybrid analysis, Dr. Trisha Davis and Dr. Eric Muller for fluorescence microscopy, Dr. David Baker for protein structure prediction, and Dr. Bill Noble for computational biology.

These services are provided to further the goal of a complete understanding of the chemical interactions required for the maintenance and faithful reproduction of a living cell. The observation that the fundamental biological processes of yeast are conserved among all eukaryotes ensures that this knowledge will shape and advance our understanding of living systems.

A list of publications generated in collaborations with the YRC can be found here. The publications highlight the impact of the YRC on collaborative research in a broad spectrum of research areas and the contributions the YRC has made in the development of the mass spectrometry and the two-hybrid technologies.