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Tag: clinical characteristics
March 23, 2021
Radiological and Functional Lung Sequelae of COVID-19: A Systematic Review and Meta-Analysis
A systematic review of PubMed and Embase to investigate characteristics of lung sequelae in COVID-19 patients found that about half of COVID-19 patients still had residual abnormalities on chest computerized tomography (CT) and pulmonary function tests (PFTs) at about 3 months after hospital discharge. Residual CT abnormalities were present in 55.7% (95% CI 41.2-70.1) of…
The Prevalence and Clinical Significance of Presymptomatic COVID-19 Patients: How We Can Be One Step Ahead in Mitigating a Deadly Pandemic
Presymptomatic patients were more likely to have atypical symptoms of COVID-19 when compared to symptomatic patients, according to a retrospective study (n=199) of patients identified via contact tracing in Malaysia. In the cohort, 21% of patients were presymptomatic, 27% were mildly symptomatic, and 52% were asymptomatic. Females were more likely to present as presymptomatic than…
March 19, 2021
Bacterial Superinfections Among Persons With Coronavirus Disease 2019: A Comprehensive Review of Data From Postmortem Studies
Potential bacterial lung superinfections were found post-mortem in 32% of persons who died of COVID-19, with proven super-infection occurring in 8% of persons who died of COVID-19, based on a review of 75 published postmortem studies including post-mortem findings from 621 COVID-19 patients. Histopathologic findings in patients with potential lung infections demonstrated diffuse pneumonia was…
March 18, 2021
Frailty as a Predictor of Mortality among Patients with COVID-19: A Systematic Review and Meta-Analysis
COVID-19 patients with frailty had a 2.5-fold higher risk of dying compared to those without frailty, according to a systematic review and meta-analysis of 15 studies including 23,944 COVID-19 patients. Subgroup analyses of studies with hospitalized patients (n=8 studies) and nursing home residents (n=2) showed that risk of dying among patients with frailty was 2.6-fold…
Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19
51% of COVID-19 survivors reported at least 1 new-onset symptom at four months after hospitalization that was not previously present in a cohort study (n=478) in France. New-onset symptoms included fatigue (31%), cognitive symptoms (21%), and shortness of breath (16%). In a subset of patients with further evaluations (n=177, including 97 of 142 former ICU…
March 15, 2021
Comparison of Clinical Characteristics and Disease Outcome of COVID-19 and Seasonal Influenza
Compared to patients with seasonal influenza treated in hospital settings, patients with COVID-19 tended to be younger (median age 59 vs 66), had fewer comorbidities at baseline with a lower Charlson Comorbidity Index (mean 3.0 vs 4.0), had a longer duration of hospitalization (mean 25.9 vs 17.2 days), more frequently needed oxygen therapy (61% vs 40%) and…
March 12, 2021
Prevention of COVID-19 among older adults receiving pneumococcal conjugate vaccine suggests interactions between Streptococcus pneumoniae and SARS-CoV-2 in the respiratory tract
Receipt of the 13-valent pneumococcal conjugate vaccine (PCV13) was associated with lower incidence of any COVID-19 diagnosis, COVID-19 hospitalization, and fatal COVID-19 hospitalization after accounting for potential sources of confounding, according to a cohort study of 531,033 US adults aged ≥65 years. Lewnard et al. (Mar 9, 2021). Prevention of COVID-19 among older adults receiving pneumococcal…
Serial interval and incubation period of COVID-19: a systematic review and meta-analysis
A systematic review and meta-analysis found that the average time between the onset of COVID-19 symptoms in an index case and the onset of symptoms in a secondary case (serial interval) was 5.2 days and the average time from infection until symptom onset (incubation period) was 6.5 days. Alene et al. (Mar 11, 2021). Serial interval…
March 11, 2021
Characteristics of and Mortality Associated With Diabetic Ketoacidosis Among US Patients Hospitalized With or Without COVID-19
30% of patients with COVID-19 and diabetic ketoacidosis (DKA) died in the hospital (64 of 210) compared to 5% of patients with DKA but without COVID-19 (262 of 4,819), according to a cohort study of 5,029 patients admitted to 175 hospitals across the US. Conducted between February to September 2020, the study also found that…
Risk of Mortality in Patients Infected with SARS-CoV-2 Variant of Concern 202012/1: Matched Cohort Study
The SARS-CoV-2 B.1.1.7 variant was associated with an overall 1.6-fold increase in risk of death compared to previously circulated variants, according to a matched cohort study (n=54,906) of patients diagnosed with SARS-CoV-2 infection in the UK between October 2020 to January 2021. Risk of death was not significantly increased within 14 days of follow-up after…
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