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Tag: clinical characteristics
March 10, 2021
Factors Linked to Severe Outcomes in Multisystem Inflammatory Syndrome in Children (MIS-C) in the USA: A Retrospective Surveillance Study
A retrospective surveillance study of multisystem inflammatory syndrome in children (MIS-C, n = 1,080 patients) found that ICU admission was more likely in patients aged 6–12 years (aOR = 1.9) and 13–20 years (aOR = 2.6) compared with patients 0–5 years, and more likely in non-Hispanic Black than non-Hispanic White patients (aOR = 1.6). Patients…
March 9, 2021
Persistence of Symptoms up to 10 Months Following Acute COVID-19 Illness
[Pre-print, not peer-reviewed] Among US individuals with a history of symptomatic COVID-19 (n=6,211) participating in a 10-wave survey between June 2020 to January 2021, 80% reported recovering within less than 2 months and 8% reported experiencing symptoms for 2 months or more. 3% and 2% reported being symptomatic for ≥4 months and ≥6 months, respectively….
Infection Sustained by Lineage B.1.1.7 of SARS-CoV-2 Is Characterised by Longer Persistence and Higher Viral RNA Loads in Nasopharyngeal Swabs
Individuals infected with the SARS-CoV-2 B.1.1.7 variant may have higher viral loads and longer viral shedding duration, according to a surveillance study in Italy. 313 individuals with sequencing-confirmed B.1.1.7 infection had lower median cycle thresholds of the SARS-CoV-2 nucleocapsid (N) protein (indicating higher viral loads) compared to individuals without B.1.1.7 infection (15.8 vs 16.9). Among…
March 8, 2021
Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers
A cohort study of 192,550 adults with COVID-19 admitted to US medical centers between March 1 and August 31, 2020 revealed that in-hospital mortality was 13.6% for the cohort. Mortality increased with age; 1.4% of patients aged 18 to 29 years died while 26.6% 80 years or older died. Among ICU patients, 27.8% died. However,…
Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020
Among 148,494 U.S. adults diagnosed with COVID-19 between March-December 2020, individuals with a BMI near the threshold between healthy weight and overweight generally had the lowest risks for hospitalization, ICU admission, and death, with higher risks associated with higher BMI. Obesity was a risk factor for hospitalization and death, particularly among adults aged <65 years….
March 5, 2021
Articles Risk of Adverse Outcomes in Patients with Underlying Respiratory Conditions Admitted to Hospital with COVID-19: A National, Multicentre Prospective Cohort Study Using the ISARIC WHO Clinical Characterisation Protocol UK
Asthma was associated with a higher likelihood over developing more severe COVID-19. Among more than 75,000 patients hospitalized with COVID-19 in the UK from January to August 2020, patients with asthma were 1.2-times as likely to receive critical care compared to patients without underlying respiratory conditions, regardless of comorbidities and disease severity at admission. Patients…
March 4, 2021
Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening
Cardiac screening among professional athletes recovering from mild COVID-19 or asymptomatic SARS-CoV-2 infection (n=789) identified 5 athletes (0.6%) with imaging evidence of inflammatory heart disease that resulted in restriction from play. Screening occurred a median of 19 days after a positive SARS-CoV-2 PCR test, though 202 (26%) athletes were diagnosed by antibody testing alone. 460…
February 26, 2021
Obesity May Hamper SARS-CoV-2 Vaccine Immunogenicity
[pre-print; not peer-reviewed] Antibody titers two weeks after receiving a second dose of the Pfizer-BioNTech vaccine were lower in obese healthcare workers (BMI >30), after adjusting for age. 99.5% of the 248 participants developed a humoral immune response after vaccination, and antibody titers were higher in younger people and in women. The authors note that…
SARS-CoV-2 Viremia Is Associated with Distinct Proteomic Pathways and Predicts COVID-19 Outcomes
[pre-print; not peer-reviewed] Levels of plasma SARS-CoV-2 viremia at the time of presentation to a hospital’s emergency department predicted both disease severity and mortality within 28 days. Viremia (defined as presence of SARS-CoV-2 RNA in plasma samples) was present in around 40% of participants and was associated with a dose-dependent effect on clinical outcome. Li…
Reduction in COVID-19 Patients Requiring Mechanical Ventilation Following Implementation of a National COVID-19 Vaccination Program — Israel, December 2020–February 2021
In Israel, the ratio of COVID-19 patients over the age of 70 requiring mechanical ventilation declined 67% compared to those under 50 from October–December 2020 to February 2021 after a national immunization program resulting in a 2-dose vaccination coverage of 84% among people over the age of 70. The authors suggest that this provides preliminary…
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