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Tag: clinical characteristics
February 25, 2021
Distinguishing Active Pediatric COVID-19 Pneumonia from MIS-C
A retrospective study among pediatric patients in Alabama (n=111, age ≤22 years) identified 100 patients with COVID-19 and 11 with multisystem inflammatory syndrome in children (MIS-C). Fever, rash, conjunctivitis, and gastrointestinal symptoms were more common in the MIS-C patients, while COVID-19 patients more commonly presented with respiratory symptoms. Patients were more likely to be males…
Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19
In a nationwide case series of 1116 patients <21 years between March and October 2020, 539 were diagnosed with multisystem inflammatory syndrome in children (MIS-C) and 577 were diagnosed with COVID-19. Patients with MIS-C were more likely to be 6-12 years old (41% vs 19%), non-Hispanic Black (32% vs 22%), and have severe cardiovascular symptoms…
February 24, 2021
Patients with Uncomplicated COVID-19 Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale during a Global Pandemic
Persistent COVID-19 symptoms at 3-4 month after infection were found in 82% of patients who had been hospitalized and 64% of those who had not been hospitalized, the most prevalent of which included fatigue and difficulty breathing (dyspnea). Patients were recruited from clinical trials occurring at a single center (Stanford). The majority had mild/moderate COVID-19…
February 23, 2021
Diabetes Is Most Important Cause for Mortality in COVID-19 Hospitalized Patients: Systematic Review and Meta-Analysis
In a systematic review and meta-analysis of 87 articles including over 35,000 patients and almost 6,000 deaths, diabetes mellitus was the best predictor of COVID-19-associated mortality rate after adjusting for confounders including age and gender, followed by chronic pulmonary obstructive disease and malignancies. Corona et al. (Feb 22, 2021). Diabetes Is Most Important Cause for Mortality…
February 22, 2021
Childhood Asthma Outcomes during the COVID‐19 Pandemic: Findings from the PeARL Multi‐national Cohort
Findings from the PeARL multinational cohort indicate that during the COVID-19 pandemic, children with asthma experienced fewer upper respiratory tract infections (RTIs), episodes of fever, emergency visits, hospital admissions, and asthma attacks and hospitalizations due to asthma than in the preceding year. When compared to non‐asthmatic controls, children with asthma were not at increased risk…
Sequelae in Adults at 6 Months After COVID-19 Infection
A longitudinal prospective cohort study of adults with laboratory-confirmed SARS-CoV-2 infection in Washington State, and a concurrent cohort of healthy (control) patients, found that persistent symptoms were reported up to 9 months after initial infection by 17 of 64 patients (27%) aged 18 to 39 years, 25 of 83 patients (30%) aged 40 to 64…
SARS-CoV-2 Shedding Dynamics Across the Respiratory Tract Sex and Disease Severity for Adult and Pediatric COVID-19
[Pre-print, not peer-reviewed] A systematic review and pooled analysis of SARS-CoV-2 shedding dynamics in the upper (URT) and lower (LRT) respiratory tracts found that severe COVID-19 in adults was characterized by high, persistent shedding of SARS-CoV-2 virus in the LRT. In the URT, adults with severe COVID-19 had higher respiratory viral loads 1 day post-symptom…
February 19, 2021
Effect of SARS-CoV-2 Infection during the Second Half of Pregnancy on Fetal Growth and Hemodynamics: A Prospective Study
Mild COVID-19 among pregnant people may not contribute to higher risk of developing fetal growth restriction, according to a single-center case-control analysis. Researchers monitored fetal growth and other factors in 49 pregnancies in patients with mild PCR+ cases diagnosed at a median of 31 weeks gestation to a control group of pregnant people who tested…
February 18, 2021
Innate Cell Profiles during the Acute and Convalescent Phase of SARS-CoV-2 Infection in Children
Cell profiles of children (n=48, aged <18 years) with clinically mild SARS-CoV-2 were characterized by reduced circulating subsets of monocytes, dendritic cells, and natural killer cells during the acute phase of infection. In contrast, adults with SARS-CoV-2 infection (n=70) showed reduced proportions of non-classical monocytes only. Both children and adults who were exposed to SARS-CoV-2…
Viral Load of SARS-CoV-2 in Adults during the First and Second Wave of COVID-19 Pandemic in Houston, TX: The Potential of the Super-Spreader
Analysis of RT-PCR test results in Houston, Texas across two epidemiologic waves from March to August 2020 (n=11,64 samples) show that an increase in the viral load among the samples tested that week preceded the peak of each wave by approximately two weeks. This relationship was more evident during the second wave when the city…
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