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Tag: clinical characteristics
November 20, 2020
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department
Delirium is a common symptom in older adults diagnosed with COVID-19 in the emergency department (ED). In this cohort study of 817 older ED patients with COVID-19, 28% had delirium at presentation, and delirium was the sixth most common of all presenting symptoms and signs. Among delirious patients, 16% presented with delirium as a primary…
Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coronavirus 2 Infection
SARS-CoV-2 infection in pregnancy was not associated with adverse pregnancy outcomes in a cohort of women in Texas. At a large county medical center, adverse pregnancy outcomes were similar in 252 SARS-CoV-2–positive and 3,122 negative pregnant women tested in outpatient and inpatient settings. Neonatal infection occurred in 3% of infants, predominantly among infants born to…
November 19, 2020
SARS-CoV-2 Viral Load on Admission Is Associated with 30-Day Mortality.
In a retrospective study of 181 patients admitted to UW Medicine hospitals, patients with a high SARS-CoV-2 viral load (Cycle threshold < 22) upon hospital admission had a 4.2-fold increase in odds of 30-day mortality. Meanwhile, those who were IgG seropositive had non-significantly lower odds of mortality (OR 0.43, 95% CI: 0.15-1.26). The authors suggest…
SARS-CoV-2 Antibody Responses Are Correlated to Disease Severity in COVID-19 Convalescent Individuals
A study evaluating novel ELISA-based assays to detect SARS-CoV-2 antibodies (including antibody sandwich ELISA and three isotype-specific assays) found that among convalescent patients (n=350), IgM, IgA, and IgG antibody responses against the receptor-binding domain significantly correlated with disease severity. Hansen et al. (Nov 18, 2020). SARS-CoV-2 Antibody Responses Are Correlated to Disease Severity in COVID-19…
November 18, 2020
Characteristics of Pediatric Multi-System Inflammatory Syndrome (PMIS) Associated with COVID-19: A Meta-Analysis and Insights into Pathogenesis
A meta-analysis of pediatric multisystem inflammation syndrome (PMIS) documented three common types of PMIS clinical presentation: persistent fever and gastrointestinal symptoms, cardiogenic shock, and Kawasaki disease-like syndrome. In 7 studies including 182 patients, only 9% of patients presented with respiratory symptoms and only 37% were positive for SARS-CoV2 by PCR, while 81% were positive for…
November 17, 2020
SARS-CoV-2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
In a multicenter study of children hospitalized with COVID-19 in New York, New Jersey, and Connecticut (n=281), over half had respiratory disease and 69/281 (25%) had multi-system inflammatory syndrome in children (MIS-C). Obesity and low blood oxygen levels (hypoxia) on admission predicted severe respiratory disease, while lower absolute lymphocyte count predicted severe MIS-C. Neither race/ethnicity…
Impact of the COVID-19 Pandemic on Invasive Pneumococcal Disease and Risk of Pneumococcal Coinfection with SARS-CoV-2: Prospective National Cohort Study, England
A national cohort study in England found a 30% decline in invasive pneumococcal disease (IPD) incidence across all age groups following COVID-19 lockdowns, similar to other reported reductions in bacterial and viral infections attributable to social distancing measures. Although IPD/COVID-19 co-infections were rare (about 0.025% of SARS-CoV-2 infections), the case fatality rates were much higher…
November 16, 2020
Newly Reported Studies on the Increase in Gastrointestinal Symptom Prevalence With COVID-19 Infection: A Comprehensive Systematic Review and Meta-Analysis
A systematic review and meta-analysis comparing the frequency of gastrointestinal symptoms among COVID-19 patients from Chinese studies conducted earlier in the epidemic and more recent studies predominantly conducted outside of China found higher rates of diarrhea, nausea/vomiting, and abdominal pain in non-Chinese studies. The pooled prevalence estimate of any GI symptom was 0.21, and the…
Association between COVID-19 Diagnosis and Presenting Chief Complaint from New York City Triage Data
A retrospective analysis of adult emergency department visits from New York City found there may be populations of patients at high risk for COVID-19 who present with atypical complaints and symptoms. While most people who received SARS-CoV-2 testing had a fever, shortness of breath, or a cough, many others who received testing reported symptoms of…
Pattern of SARS-CoV-2 Infection among Dependant Elderly Residents Living in Long-Term Care Facilities in Marseille, France, March–June 2020
Results from a SARS-CoV-2 PCR-based screening campaign found a high proportion of asymptomatic infection among residents and staff of long-term care facilities in France, with higher frequencies among residents than staff (13.4% versus 8.7%). Among infected residents, 16.4% were detected based on symptoms and 83.6% through mass screening. While many SARS-CoV-2 positive residents had respiratory…
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