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Tag: vaccines
January 5, 2021
Confidence and Receptivity for COVID-19 Vaccines: A Rapid Systematic Review
A systematic review and meta-analysis showed declining COVID-19 vaccine acceptance, from >70% in March to <50% in October. In an analysis of data from 126 studies and surveys, drivers of decline in vaccine acceptance included perceived risk, concerns over vaccine safety and effectiveness, doctors’ recommendations, and inoculation history. In assessing the impact of survey design,…
Comprehensive Mapping of Mutations to the SARS-CoV-2 Receptor-Binding Domain That Affect Recognition by Polyclonal Human Serum Antibodies
[Pre-print, not peer reviewed] Mutations in three main epitopes of the SARS-CoV-2 spike receptor-binding domain (RBD) affect neutralizing activity of convalescent polyclonal serum. Mutations that affect neutralizing activity usually occur at only a few sites and mutations occurring at the E484 site had the largest average effect with a >10 fold reduction in the neutralization…
January 4, 2021
Timing of COVID-19 Vaccine Approval and Endorsement by Public Figures
A study using two randomized experiments embedded in surveys found that perceptions of political influence on the COVID-19 vaccine approval process in the US could impact the confidence in, and uptake of vaccines. Announcing approval of a COVID-19 vaccine one week before the presidential election, compared to one week after, reduced reported intentions to vaccinate…
Efficacy and Safety of the MRNA-1273 SARS-CoV-2 Vaccine
Results from a phase 3 randomized, observer-blinded, placebo-controlled trial of the Moderna SARS-CoV-2 vaccine candidate (mRNA-1273) indicated that the vaccine showed 94.1% efficacy at preventing COVID-19, including severe disease. The trial enrolled 30,420 volunteers, and symptomatic illness was confirmed in 185 participants in the placebo group and in 11 participants in the vaccine group. Efficacy…
December 30, 2020
National Trends in the US Public’s Likelihood of Getting a COVID-19 Vaccine—April 1 to December 8, 2020
A nationally representative longitudinal survey (n=8,167) found that self-reported likelihood of getting a COVID-19 vaccine declined from 74% in early April to 56% in early December. Declines were observed in likelihood of vaccine uptake for both women and men and in all age, racial/ethnic, and education subgroups. As of December, the self-reported likelihood of vaccine…
December 28, 2020
Older Adults’ Perspectives on a COVID-19 Vaccine
In a nationally representative survey of 1,556 adults aged 50 to 80 years in the US (October 2020), 58% of older adults indicated they would be likely to get a COVID-19 vaccine, 28% said they were unlikely, and 14% were either unsure or did not know if they would get vaccinated. Interest in getting a…
December 23, 2020
Evaluating the Efficacy of COVID-19 Vaccines
Using dual or triple primary endpoints that include SARS-CoV-2 infection, symptomatic infection and severe COVID-19 could speed up characterization and licensure of vaccines for SARS-CoV-2, according to models of placebo controlled-vaccine trials. The authors suggest that dual or triple primary endpoints could speed up the discovery, characterization, and licensure of effective vaccines by creating data…
The Advisory Committee on Immunization Practices’ Updated Interim Recommendation for Allocation of COVID-19 Vaccine — United States, December 2020
The Advisory Committee on Immunization Practices (ACIP) now recommends that the COVID-19 vaccine be offered to people over the age of 75 and non-health care frontline workers in Phase 1B of the vaccine rollout. This is an update to recent vaccine allocation recommendations that suggested vaccinating health care personnel and long-term care facility residents against…
December 21, 2020
The Challenges of the Coming Mass Vaccination and Exit Strategy in Prevention and Control of COVID-19 a Modelling Study
[Pre-print, not peer-reviewed] A modeling study of potential vaccination scenarios in China, Brazil, Indonesia, Russia, UK, and the US showed that there was a critical (minimum) vaccination coverage needed for each country to balance the discontinuation of non-pharmaceutical interventions (NPIs) while avoiding a subsequent wave of infections, depending on effectiveness of NPIs. The authors concluded…
Sub-National Forecasts of COVID-19 Vaccine Acceptance across the UK a Large-Scale Cross-Sectional Spatial Modelling Study
[Pre-print, not peer-reviewed] A predictive modeling study of vaccine hesitancy in the UK that used a large-scale survey data and Bayesian statistical methods to estimate public opinion predicted that clusters of non-vaccinators will likely emerge in many regions across the UK, including London and the North West. Respondents (n= 17,684) were surveyed between September 24…
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