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Topic: Clinical Characteristics and Health Care Setting
April 6, 2021
Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic
Peaks in the incidence of multisystem inflammatory syndrome in children (MIS-C) occurred 2-5 weeks after peaks in the incidence of COVID-19 and clinical manifestations of MIS-C varied by age. These findings were based on a cross-sectional study of 1,733 patients with MIS-C in the United States. Children age 0-4 had the lowest proportion of severe…
April 2, 2021
COVID-19 in Individuals with Sickle Cell Disease/Trait Compared with Other Black Individuals
Persons diagnosed with COVID-19 and sickle cell disease (SCD) (n=312) were 2-times as likely to be hospitalized and develop pneumonia and 3-times as likely to develop pain compared to a propensity matched cohort of Black persons diagnosed with COVID-19 but without SCD or sickle cell trait (SCT). No significant differences were observed in case mortality…
April 1, 2021
Post-Acute Sequelae of COVID-19 in a Non-Hospitalized Cohort Results from the Arizona CoVHORT
[Pre-print, not peer-reviewed] 69% of non-hospitalized individuals infected with SARS-CoV-2 in Arizona (n=303) experienced post-acute sequelae of SARS-CoV-2 infection (PASC, experiencing at least one symptom for ≥30 days). In a subset of the cohort (n=157) followed for >60 days, prevalence of PASC was 77%. Participants were followed for a median of 61 days; during follow-up,…
Post-Covid Syndrome in Individuals Admitted to Hospital with Covid-19: Retrospective Cohort Study
Individuals discharged following hospitalization for COVID-19 were 4 and 8 times more likely to be readmitted and to die compared to controls matched for personal and clinical characteristics. In this retrospective cohort study, 47,780 patients with COVID-19 discharged by August 2020 were matched to a pool of about 50 million people in England. Nearly a…
March 31, 2021
COVID-19 Case and Mortality Rates in the Federal Bureau of Prisons
A study of COVID-19 in US Federal Prisons found that both the case rate and mortality was higher among inmates in these facilities compared to the general population. The crude case rate (11,710 per 100,000 population) was 5-times higher than that in the general population and the age- and sex-adjusted mortality rate for COVID-19 (77.4…
March 23, 2021
Radiological and Functional Lung Sequelae of COVID-19: A Systematic Review and Meta-Analysis
A systematic review of PubMed and Embase to investigate characteristics of lung sequelae in COVID-19 patients found that about half of COVID-19 patients still had residual abnormalities on chest computerized tomography (CT) and pulmonary function tests (PFTs) at about 3 months after hospital discharge. Residual CT abnormalities were present in 55.7% (95% CI 41.2-70.1) of…
March 19, 2021
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape
The infectivity of the 501Y.V2 variants (which include the B.1.351 variant that was first identified in South Africa) was not significantly different than the reference strain (D614G) across multiple cell types. The neutralizing activity of multiple RBD-targeting monoclonal antibodies decreased significantly, and polyclonal antibodies (from RBD-immunized mouse sera and from SARS-CoV-2 convalescent sera) also had…
Bacterial Superinfections Among Persons With Coronavirus Disease 2019: A Comprehensive Review of Data From Postmortem Studies
Potential bacterial lung superinfections were found post-mortem in 32% of persons who died of COVID-19, with proven super-infection occurring in 8% of persons who died of COVID-19, based on a review of 75 published postmortem studies including post-mortem findings from 621 COVID-19 patients. Histopathologic findings in patients with potential lung infections demonstrated diffuse pneumonia was…
Variation in COVID-19 Mortality Across 117 US Hospitals in High- and Low-Burden Settings
Patients admitted to the most COVID-19 burdened hospitals had increased mortality compared to non-burdened hospitals, according to an analysis of patient admission data (n=14,226 patients) from an administrative database in April 2020. As of June 2020, 21% of all patients admitted with a COVID-19 diagnosis had died, and 1% remained hospitalized. At the hospital level,…
March 18, 2021
Frailty as a Predictor of Mortality among Patients with COVID-19: A Systematic Review and Meta-Analysis
COVID-19 patients with frailty had a 2.5-fold higher risk of dying compared to those without frailty, according to a systematic review and meta-analysis of 15 studies including 23,944 COVID-19 patients. Subgroup analyses of studies with hospitalized patients (n=8 studies) and nursing home residents (n=2) showed that risk of dying among patients with frailty was 2.6-fold…
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