Result for
Topic: Clinical Characteristics and Health Care Setting
June 5, 2020
Prevalence and Severity of Coronavirus Disease 2019 (COVID-19) Illness in Symptomatic Pregnant and Postpartum Women Stratified by Hispanic Ethnicity
Among pregnant or immediately postpartum women with COVID-19 symptoms or an epidemiologic link to a case, women of self-reported Hispanic ethnicity were disproportionately represented (60%, vs 18% in the population). Hispanic women were no more likely than non-Hispanic women to be hospitalized, but they were more likely to be admitted to the ICU and to be intubated. …
June 4, 2020
Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children’s Hospital in New York City, New York
A case series of 50 children and adolescents hospitalized with COVID-19 in New York City showed that patients with severe disease had significantly higher C-reactive protein and procalcitonin levels at admission, as well as elevated peak IL-6, ferritin, and D-dimer levels during hospitalization. Infants and immunocompromised patients were not at increased risk of severe disease. Zachariah et al. (June 3, 2020). Epidemiology,…
The Need of Health Policy Perspective to Protect Healthcare Workers during COVID-19 Pandemic. A GRADE Rapid Review on the N95 Respirators Effectiveness
A systematic review of 4 randomized trials involving 8,736 healthcare workers showed that, compared to surgical masks, wearing N95 respirators was associated with a lower risk of clinical respiratory infections (RR=0.43, 95%CI 0.29-0.64), corresponding to 73 (46-91) fewer infections per 1000 persons. No direct high–quality evidence was found on whether N95 respirators were better than surgical masks for protection from SARS-CoV-2. Iannone et…
Acute Myocarditis and Multisystem Inflammatory Emerging Disease Following SARS-CoV-2 Infection in Critically Ill Children
Grimaud et al. report a case series of 20 children admitted to PICUs in Paris with shock, fever, and suspected SARS-CoV-2 infection. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. All of the children had cardiac abnormalities consistent with acute myocarditis. All children had highly –elevated C-reactive protein and procalcitonin. None of the patients had sufficient criteria for typical Kawasaki disease. …
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020
Benameur et al. present a case series of 3 patients with COVID-19 who developed encephalopathy and encephalitis. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM, IL-6, IL-8, and IL-10. No SARS-CoV-2 was identified in any CSF sample. These changes provide evidence of CSF peri-infectious/post-infectious inflammatory changes with neurologic complications. Benameur et al. (June 2, 2020). Encephalopathy and…
June 3, 2020
Prevalence of SARS-CoV-2 Antibodies Among Healthcare Workers at a Tertiary Academic Hospital in New York City
[pre-print, not peer reviewed] Mansour et al. found that 33% of 285 healthcare workers at a tertiary academic hospital in New York City tested positive for SARS-CoV-2 IgG antibodies. These findings highlight that inpatient and ambulatory frontline staff had high levels of exposure to SARS-CoV-2, most of whom were working in the weeks preceding immunological testing. Mansour et al. (June 2,…
ACE-Inhibitors and Angiotensin-2 Receptor Blockers Are Not Associated with Severe SARS-COVID19 Infection in a Multi-Site UK Acute Hospital Trust
It has been hypothesized that ACE-inhibitors and angiotensin-2 blockers, medications commonly prescribed to patients with hypertension or diabetes, could increase the risk of severe COVID-19 infection by increasing the number of ACE2 receptors that SARS-CoV-2 uses for cell entry. However, Bean et al. found no evidence for increased risk of ICU admission or death associated with these medications in a cohort of 1,200 hospitalized COVID-19…
Lymphopenia in Severe Coronavirus Disease-2019 (COVID-19): Systematic Review and Meta-Analysis
Huang and Pranata conducted a meta-analysis of lymphocyte count and severity of COVID-19 disease. Results from 24 studies suggest that patients with poor clinical outcomes have a lower lymphocyte count (mean difference – 361.06 μL) compared to those with good outcomes. This finding persisted in subgroup analysis, which revealed lower lymphocyte counts in patients who died,…
June 2, 2020
Pediatric COVID-19 in Southern California Clinical Features and Viral Genetic Diversity
[pre-print, not peer reviewed] An observational study of COVID-19 pediatric patients (n=35) in Southern California showed diverse clinical presentations, with greater disease severity was associated with higher viral load and younger age. The authors found no correlation between disease severity and viral genetic variations. Pandey et al. (June 1, 2020). Pediatric COVID-19 in Southern California Clinical Features and Viral Genetic Diversity. Preprint downloaded June 2 from https://doi.org/10.1101/2020.05.28.20104539
The Prevalence of Antibodies to SARS-CoV-2 in Asymptomatic Healthcare Workers with Intensive Exposure to COVID-19
[pre-print, not peer reviewed] Xiong et al. surveyed 797 asymptomatic healthcare workers with intensive exposure to COVID-19 patients in Wuhan, China and found that positive IgG was detected in 35, leading to a seroprevalence of 4.4%. Xiong et al. (June 2, 2020). The Prevalence of Antibodies to SARS-CoV-2 in Asymptomatic Healthcare Workers with Intensive Exposure to COVID-19. Preprint downloaded June 2 from https://doi.org/10.1101/2020.05.28.20110767
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