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Topic: Clinical Characteristics and Health Care Setting
May 7, 2021
Risk Factors For Infection And Health Impacts Of The Covid-19 Pandemic In People With Autoimmune Diseases
A prospective cohort study of persons with autoimmune or inflammatory conditions (N=4,666) found that persons with diabetes (OR=1.7), cardiovascular disease (OR=1.7) and kidney disease (OR=1.8) and patients taking glucocorticoid drugs (OR=1.4) had higher risks of COVID-19. Interruptions to healthcare were common, and persons with changes in their ability to pay for healthcare costs and those…
Risk of COVID-19 in Rheumatoid Arthritis: A National Veterans Affairs Matched Cohort Study in At-Risk Individuals
A matched cohort study of US veterans (N=66,772) found that persons with rheumatoid arthritis had a higher risk of COVID-19 disease (HR=1.25) and COVID-19 associated hospitalization or death (HR=1.35) compared to age-, sex-, and Veterans Administration-site-matched persons without rheumatoid arthritis. Persons on immunosuppressant drugs (DMARDS and prednisone) had the highest risk of COVID-19 and severe…
May 6, 2021
SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19
In a sample of 191 COVID-19 patients presenting to the emergency department, viral RNA detected in blood (RNAemia) by digital PCR (dPCR) was associated with poor clinical outcomes. DCR was more sensitive than quantitative PCR (qPCR) in detecting RNAemia, or viral RNA in plasma (23% vs 1.4%). RNAemia was undetectable within 10 days of symptom…
SARS-CoV-2 Viral Load Kinetics in Symptomatic Children, Adolescents and Adults
Mean viral load (VL) was slightly lower at the time of SARS-CoV-2 infection diagnosis for children aged 0-13 years (6.2 log10 copies/mL) and adolescents aged 14-19 years (6.4 log10 copies/mL) compared to adults aged ≥20 years (6.7 log10 copies/mL) in a study in Switzerland (n=8,027). At time of diagnosis, the proportion of adults with VL…
May 5, 2021
Rapid Emergence and Epidemiologic Characteristics of the SARS-CoV-2 B.1.526 Variant — New York City, New York, January 1–April 5, 2021
The SARS-CoV-2 B.1.526 variant, a variant of concern/interest (VOC/VOI) first described in New York City (NYC), does not appear to lead to more severe disease, increased risk of infection after vaccination, or increased risk of reinfection according to preliminary analyses of infections with sequenced virus matched to epidemiologic characteristics in NYC from January to April…
SARS-CoV-2 Outbreak in Immune-Mediated Inflammatory Diseases: The Euro-COVIMID Multicentre Cross-Sectional Study
In a study including 3,028 patients in Europe with immune-mediated inflammatory disease, symptomatic COVID-19 occurred in 4% (n=122) and anti-SARS-CoV-2 antibodies were detected in 5% (n=166) of patients between June and December 2020. Symptomatic COVID-19 was associated with higher concentrations of C-reactive protein (OR=1.2) and higher numbers of disease flares (OR=1.3). Saadoun et al. (Apr 2021)….
Persistent Neuropsychiatric Symptoms after COVID-19 a Systematic Review and Meta-Analysis
[Pre-print, not peer-reviewed] In a systematic review and meta-analysis of neuropsychiatric symptoms in COVID-survivors (51 studies of 18,917 COVID-19 survivors), sleep disturbance was the most common neuropsychiatric symptom with a pooled prevalence of 27%, followed by fatigue (24%), objective cognitive impairment (also known as brain fog, 20%), anxiety (19%), and post-traumatic stress (16%). Mean duration…
May 4, 2021
Human Organoid Systems Reveal in Vitro Correlates of Fitness for SARS-CoV-2 B.1.1.7
[Pre-print, not peer-reviewed] In an in vitro human organoid system, the SARS-CoV-2 B.1.1.7 variant was shown to produce higher levels of infectious virus late in infection and higher replicative fitness in human airway, alveolar, and intestinal organoid models compared to the ancestral strain. Lamers et al. (May 3, 2021). Human Organoid Systems Reveal in Vitro Correlates…
April 30, 2021
SARS-CoV-2 Seroprevalence, and IgG Concentration and Pseudovirus Neutralising Antibody Titres after Infection, Compared by HIV Status: A Matched Case-Control Observational Study
Persons living with HIV had lower SARS-CoV-2 IgG seroprevalence (3.7%) compared to persons without HIV (7.4%), according to a retrospective matched case-control study (N=2,200) of remnant serum samples from US adults presenting for routine laboratory testing. However, among those who had past SARS-CoV-2 infection, persons living with HIV were more likely to have had severe…
April 28, 2021
Half-year Follow-up of Patients Recovering from Severe COVID-19: Analysis of Symptoms and Their Risk Factors
More than half (55.4%, n = 441) of patients who recovered from severe COVID-19 had persistent symptoms (“sequelae”) at six months follow-up. The most common symptoms were fatigue (25.3%), sleep disorder (23.2%) and shortness of breath (20.4%). Compared to those who had been severely ill (defined as hypoxia without respiratory failure), individuals who had been…
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