Result for
Topic: Geographic Spread
November 13, 2020
The Change in Seroprevalence in the US plus Puerto Rico between May and September of SARS-CoV-2 Antibody in the Asymptomatic Population
[Pre-print, not peer-reviewed] The prevalence of SARS-CoV-2 antibodies among asymptomatic individuals in the US more than doubled during May to September (3.0% to 6.6%), with the greatest increase observed in younger individuals (< age 20, 7.8%). Antibody prevalence was similar among males and females, but varied by age. Based on the September prevalence, there were…
November 12, 2020
Large Scale Genomic Analysis of 3067 SARS-CoV-2 Genomes Reveals a Clonal Geo-Distribution and a Rich Genetic Variations of Hotspots Mutations
A large-scale analysis of 3067 SARS-CoV-2 genomes from 55 countries tracked mutations within the virus genome and identified three major clades in various geographic regions. The analysis also revealed geographic mutation hotspots – in particular, China, the US, France, and Malaysia – contained a high number of specific mutations. The authors note the high number…
November 5, 2020
Revealing Fine-Scale Spatiotemporal Differences in SARS-CoV-2 Introduction and Spread
Analysis of 247 SARS-CoV-2 sequences from two nearby communities in Wisconsin illustrate distinct patterns of viral spread. Though Dane County had the 12th known introduction of SARS-CoV-2 in the US, this did not lead to community spread. 60 miles away, Milwaukee County experienced few introductions followed by extensive community spread. Moreno et al. (Nov 3,…
November 3, 2020
Age-Specific Mortality and Immunity Patterns of SARS-CoV-2
Using age-specific COVID-19 death data and seroprevalence studies, the age distribution of deaths among those <65 years old was consistent across 45 countries. The infection fatality ratio (IFR) was estimated to be the lowest among children aged 5-9 years old (0.001%) and increased with age. The highest IFR was observed among those 80+ (8.3%). Mortality…
October 29, 2020
Emergence and Spread of a SARS-CoV-2 Variant through Europe in the Summer of 2020
[Pre-print, not peer reviewed] Phylogenetic analysis found that a SARS-CoV-2 variant has emerged in Spain since mid-July with a frequency over 40%. Sequences in this cluster differ from ancestral sequences at 6 or more positions. The variant spread to multiple European countries, with frequencies increasing from low values prior to mid-July to 40-70% in Switzerland,…
October 26, 2020
Seropositive Prevalence of Antibodies Against SARS-CoV-2 in Wuhan, China
A cross-sectional study of healthy adults in Wuhan, China (n=35,040) with no prior history of COVID-19 found that the seroprevalence was 3.9% among the study population in samples taken eight weeks following the peak infection period. Most individuals tested positive for SARS-CoV-2 IgG antibodies only, indicating previous infection. Seropositive prevalence was higher in urban areas…
October 8, 2020
Analysis of Genomic Characteristics and Transmission Routes of Patients With Confirmed SARS-CoV-2 in Southern California During the Early Stage of the US COVID-19 Pandemic
In a case series of 192 patients from Los Angeles, a genomic analysis found that 82% of SARS-CoV-2 isolates were most similar to isolates from Europe, while 15% were most similar to isolates from Asia. Genetic characterization of isolates identified community transmission in 13 patients, including 10 related to skilled nursing facilities, while person-to-person transmission…
October 6, 2020
Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
Geographic Spread Genomic analysis of 6,359 SARS-CoV-2 isolates from the US identified a pattern of strongly localized outbreaks, which may point to the effectiveness of travel restriction policies and other public health measures. The authors identified prominent trends of localized haplotype patterns, which are the collection of variants in a viral genome, particular to Washington…
October 1, 2020
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures
The seroprevalence of anti-SARS-CoV-2 IgG among people accessing health care for reasons other than COVID-19 symptoms in a low-density, suburban and rural population in North Carolina was 0.8% (24 of 2973) of outpatients and 0.7% (10 of 1449) of inpatients. Participants were sampled between March and June 2020, when state restrictions and physical distancing mandates…
September 28, 2020
Prevalence of SARS-CoV-2 Antibodies in a Large Nationwide Sample of Patients on Dialysis in the USA: A Cross-Sectional Study
In a large sample of US adults who received dialysis (n=28,503), the seroprevalence of antibodies against SARS-CoV-2 was 8.0%, ranging from 3.5% in the west to 27.2% in the northeast. Seropositivity was higher in neighborhoods with predominantly non-Hispanic Black (OR=3.9) and Hispanic (OR=2.3) residents (vs white) and neighborhoods in the highest population density quintile (OR=10.3)…
Previous page Next page