Alliance for Pandemic Preparedness

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Topic: Non-Pharmaceutical Interventions


April 30, 2020

Evaluation of “stratify and shield” as a policy option for ending the COVID-19 lockdown in the UK

McKeigue and Colhoun suggest that a ‘stratify-and-shield’ policy–a strategy that would shield elderly and others at high risk of severe disease, while allowing immunity to build up in those at low risk until the entire population is protected– has potential to save lives, and restore economic activity.  In spite of key uncertainties about the theoretical…


April 28, 2020

Comparison of SARS-CoV-2 Exit Strategies Building Blocks

The authors compare various exit strategy building blocks and measures to mitigate the current SARS-CoV-2 pandemic based on computerized simulations, finding significant differences in suppression among strategies with seemingly similar cost.   The most effective strategies found integrate several base strategies, and allow for the release of large portions of the population. Stratified population release to…


April 23, 2020

CAN-NPI: A Curated Open Dataset of Canadian Non-Pharmaceutical Interventions in Response to the Global COVID-19 Pandemic

This study describes the rapid development of the first comprehensive, labeled dataset of 1,640 NPIs implemented at federal, provincial/territorial and municipal levels in Canada to guide COVID-19 research.  McCoy et al. (Apr 17, 2020). CAN-NPI: A Curated Open Dataset of Canadian Non-Pharmaceutical Interventions in Response to the Global COVID-19 Pandemic. Pre-print downloaded Apr 23 from…


April 22, 2020

A Controlled avalanche – A regulated voluntary exposure approach for addressing Covid-19

Klement et al used a compartmental model to examine the implications of the controlled avalanche (CA) strategy over the population in Israel. Its main goal is to approach herd immunity faster than the current alternatives, with lower mortality rates and lower demand for critical health-care resources. It involves voluntarily exposing low risk groups (20-49 year…


April 21, 2020

Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study

The authors analyzed data on influenza and coronavirus transmission in response to non-pharmaceutical interventions implemented in Hong Kong. COVID-19 transmission has slowed, with an R1 (transmission rate per case) of ~1 sustained for 8 weeks, and influenza community transmission has been reduced by 44%, with a 33% reduction in pediatric hospitalization rates. This study shows…


The effect of inter-city travel restrictions on geographical spread of COVID-19: Evidence from Wuhan, China

The authors assess the effectiveness of travel restrictions in Wuhan on delaying or reducing transmission of COVID-19 to other major cities in China. They conclude that restrictions alone did not have a substantial impact, as local transmission in other cities had already been occurring prior to implementation. Quilty et al. (April 21, 2020). The effect…


The estimated impact of non-pharmaceutical interventions on documented cases of COVID-19: A cross-country analysis

The authors provide estimates on the effectiveness of various non-pharmaceutical interventions based on early estimates from 20 countries, including the US.    Closure of venues was associated with a 33% reduction in new cases (95% CI: 16-47%), bands on non-essential business with a 28% reduction (10-42%), border closures with a 26% reduction (13-37%), and school closures…


April 17, 2020

Public Policy and economic dynamics of COVID-19 spread: a mathematical modeling study

In order to assess the impact of quarantine measures on deaths, hospitalizations and economic output, this modeling study that looked at various scenarios founds that when quarantine is quickly lifted, a second outbreak takes place, whereas strict restrictions on seniors combined with gradual lifting of quarantine for the general population resulted in a limited number…


The Effect of Stay-at-Home Orders on COVID-19 Infections in the United States

Using data on stay-at-home orders and daily confirmed COVID-19 cases at the county level in the U.S., this modeling study suggests that if a national stay-at-home order was issued on March 13 when a national emergency was declared, the number of infections and deaths may have reduced by hundreds of thousands and thousands, respectively.  The…


April 16, 2020

Impact of population mask wearing on Covid-19 post lockdown

Using a simplified SIR model to investigate the effects of near-universal mask use on COVID-19, the authors state that mask use had a relatively minor benefit on critical-care and mortality rates when transmissibility was high. However, when the RE approached 1 (as might be expected after aggressive social-distancing measures), the model finds a significant reduction…



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