Result for
Topic: Vaccines and Immunity
April 7, 2021
Efficient Maternofetal Transplacental Transfer of Anti- SARS-CoV-2 Spike Antibodies after Antenatal SARS-CoV-2 BNT162b2 MRNA Vaccination
In a study of women who received the Pfizer (SARS-CoV-2 BNT162b2) vaccine, all 20 women and infants had detectable anti S- and anti-RBD-specific IgG. Anti-S and anti-RBD-specific IgG antibody levels in maternal sera were positively correlated to their respective concentrations in cord blood (correlation rho= 0.72; P<0.001 and correlation rho= 0.72; P <0.001, respectively) suggesting…
Unraveling Attributes of COVID-19 Vaccine Hesitancy in the U.S. A Large Nationwide Study
[Pre-print, not peer-reviewed] A study conducted in December 2020-January 2021, among 34,470 US users of a COVID-19-focused smartphone-based app found that 83% of respondents were accepting of the vaccine. Among users who expressed vaccine hesitancy, the majority were undecided about accepting vaccination. Vaccine hesitancy was significantly higher among females, younger people, minority and low-income communities,…
Antibody Persistence through 6 Months after the Second Dose of MRNA-1273 Vaccine for Covid-19
Neutralizing antibody activity elicited by the Moderna vaccine remained high 6 months after the second dose in all 33 adults in an ongoing phase 1 trial, as measured by 3 different serologic assays. Binding antibody half-life estimates after day 43 for all the participants were 52 days when calculated via an exponential decay model (assumes…
Anti-SARS-CoV-2 RBD IgG Responses in Convalescent versus Naïve BNT162b2 Vaccine Recipients
IgG responses measured 14 days after the first and second dose of the Pfizer-BioNTech vaccine among convalescent individuals (n = 12) and age- and sex-matched individuals with no prior infection (n = 54) showed that convalescent individuals showed higher absolute anti-S1/S2 IgG levels (220 ± 42 vs. 37 ± 3 AU/ml) compared to naïve vaccinees at 14 days after the first dose….
April 6, 2021
No Psychological Vaccination: Vaccine Hesitancy Is Associated with Negative Psychiatric Outcomes among Israelis Who Received COVID-19 Vaccination
Clinical depression, peri-traumatic distress, and clinical anxiety were associated with vaccine hesitancy in a cross-sectional study (n=254) of vaccinated participants aged ≥60 years in Israel. Palgi et al. (Mar 26, 2021). No Psychological Vaccination: Vaccine Hesitancy Is Associated with Negative Psychiatric Outcomes among Israelis Who Received COVID-19 Vaccination. Journal of Affective Disorders. https://doi.org/10.1016/j.jad.2021.03.064
COVID-19 MRNA Vaccines Drive Differential Fc-Functional Profiles in Pregnant Lactating and Non-Pregnant Women
[Pre-print, not peer-reviewed] The antibody response induced by mRNA vaccines (Moderna and Pfizer-BioNTech) after the first dose was lower among pregnant (n=84) and lactating (n=31) women compared to non-pregnant age-matched controls (n=16), but after the second dose no significant differences were observed. Differences in antibody response after the first dose related to lower antibody titers…
Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines
Local and systemic adverse reactions within 7 days of vaccination were more frequently self-reported by those who received the Moderna vaccine compared to those who received the Pfizer-BioNTech vaccines. Reactions were also more frequently reported after the second dose of these vaccines. These findings are based on V-Safe, a CDC surveillance system that included 3.6…
April 5, 2021
Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection
A study of hospitalized and non-hospitalized symptomatic patients (n = 210 samples, 84 patients) over a period of 10 months using six different commercial assays for antibody detection found that assays targeting total antibodies presented higher positivity rates and reached the highest positivity rates sooner than assays directed against IgG alone. The inter-assay agreement was…
Antibody Responses to the BNT162b2 MRNA Vaccine in Individuals Previously Infected with SARS-CoV-2
Among healthcare workers in California who received the Pfizer-BioNTech vaccine (n = 1,090), spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses were similar between individuals who had been previously infected with SARS-CoV-2 and received a single dose (n = 35), and those who had no prior infection and received both vaccine doses (n…
April 2, 2021
SARS-CoV-2 Immune Evasion by Variant B.1.427B.1.429
[Pre-print, not peer-reviewed] The SARS-CoV-2 variant CAL.20C (also known as B.1.427/B.1.429, with key mutations S13I, W152C and L452R), which was first described in California, has plasma neutralizing activity that is 3- to 4-fold lower in individuals fully vaccinated with the Moderna or Pfizer-BioNTech vaccines compared to the wild-type SARS-CoV-2 strain. Reduction in neutralizing activity among…
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