The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders. We use the zebrafish as an animal model because of its advantages for genetic manipulations, in vivo imaging, and drug screening.
We currently have three main projects.
1) We are investigating the mechanisms of skeletal muscle fiber-type differentiation. This work will eventually help us understand why certain types of muscle fibers are more susceptible to muscular dystrophy.
2) We are using a zebrafish model of Duchenne muscular dystrophy (the dmd mutant strain) to investigate new drug therapies for DMD. We take advantage of the fish model to identify potential combination drug therapies that are beneficial for DMD.
3) We are using CRISPR-Cas9 genome editing in zebrafish to engineer mutations in genes that have been implicated in human congenital heart defects. Our goal is to gain insight into the functions of these genes in heart development.
Contact Lisa Maves directly at lmaves (at) u.washington.edu.