Research


Murry Receives Presidential Early Career Award

Studies How Body Repairs Damage from Heart Attack

Investigating the biology of myocardial infarction and the ways the body repairs damage from a heart attack led to a Presidential Early Career Award for Scientists and Engineers for Dr. Charles Murry, associate professor of pathology.

The Murry lab is studying the mechanisms that regulate repair of the infarcted heart. The lab is also developing molecular strategies to induce muscle regeneration. This regeneration would reduce scarring of the heart and prevent post-infarction cardiac dysfunction. Murry is exploring—among other strategies—the transplantation of stem cells for healing infarcts.

Murry said he enjoys the open, collegial spirit at the UW. “I’m a pathologist interested in acquired diseases like heart attacks,” he said, “and I’ve found that seemingly separate disciplines can address a common project in very effective ways. We’re collaborating, for example, with Dr. Steve Hauschka from the biochemistry department. He is a developmental biologist who studies how skeletal and cardiac muscle develop from undifferentiated stem cells. His expertise in development has contributed substantially to our use of skeletal muscle, cardiac muscle, and stem cells to repair damaged hearts.

“We’re collaborating in another way with Dr. Tony Blau, a hematologist who is interested in ways to repopulate bone marrow after a bone marrow transplant. As it happens, that work has led to promising applications in repopulating the heart with muscle cells after a heart attack. Collaborations like these can substantially increase the rate of discovery and invention.”

Charles Murry
Charles Murry



























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