Sort publications by:

2011-2012 | 2010-2006 | 2005-2000 | 1999-1995 | Prior to 1995

Publications not available in pdf format may be obtained by contacting Lawrence A. Loeb


Publications 2011-2012

Kamath-Loeb AS, Shen JC, Schmitt MW, and Loeb LA. The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase δ*. J. Bio. Chem. VOL. 287, NO. 15, pp. 12480–12490, April 6, 2012. [ pdf ]

Kamath-Loeb AS, Loeb LA, Fry M. The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures. PLoS One [ pdf ]

Kennedy, S.R., et al., Somatic mutations in aging, cancer and neurodegeneration. Mech. Ageing Dev. (2011), doi:10.1016/j.mad.2011.10.009. [ pdf ]

Kamath-Loeb AS, Loeb LA. XPG and WRN: An unexpected partnership Comment on: Trego KS, et al. Cell Cycle 2011; 10:1998–2007. Landes Bio. Science. [ pdf ]

Allen JM, Simcha DM, Ericson NG, et al., Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication. Nucleic Acids Research. 2011, 1–14. [ pdf ]

Wright JH, Modjeski KL, Bielas JH, et al., A random mutation capture assay to detect genomic point mutations in mouse tissue. Nucleic Acids Research. 2011, 1-12. [ pdf ]

Loeb LA. Human cancers express mutator phenotypes: origin, consequences and targeting. Nature. 2011 June (11). [ pdf ]

Kennedy SR, Chen CY, Schmitt MW, Bower CN, Loeb LA. The Biochemistry and Fidelity of Synthesis by the Apicoplast Genome Replication DNA Polymerase Pfprex from the Malaria Parasite Plasmodium falciparum. J. Mol. Bio. 2011. [ pdf ]

Mullins JI, Heath L, Hughes JP, et al., Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461. PLoS One 2011. [ pdf ]


Publications 2010

Loh E, Salk JJ, Loeb LA. Optimization of DNA polymerase mutation rates during bacterial evolution. Proc Natl Acad Sci. USA. (2010) Jan 19;107(3):1154-1159. [ pdf ]

Fox E, Loeb LA. Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer. Semi. Canc. Biol 20 (2010): 353-359. [ pdf ]

Fox EJ., Beckman RA., Loeb LA. Reply: Is there any genetic instability in human cancer? DNA Repair 9 (2010): 859-860 [ pdf ]

Schmitt MW., et al. Active Site Mutations in Mammalian DNA polymerase Alter Accuracy and Replication Fork Progression J. Bio. Chem. Vol 285 No 42 pp 32264-32272 [ pdf ]

Loeb LA. Mutator phenotype in cancer: Origin and consequences. Sem Canc. Biol.(2010). [ pdf ]

Prindle MJ. Fox EJ, Loeb LA. The Mutator Phenotype in cancer: Molecular Mechanisms and targeting Strategies. Curr Drug Targets, 2010 11, 1296-1303 [ pdf ]

Klapacz J., et al. Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase. Mol. Cell 37, 843-853 (2010). [ pdf ]

Hsu JJ., et al. Werner Syndrome Gene Variants in Human Sarcomas. Mol. Carcinogenesis 49: 166-174 (2010) [ pdf ]

Ladiges W., et al. A Mitochondrial view of aging, reactive oxygen species and metastatic cancer. Aging Cell (2010) 9, pp462-465. [ pdf ]

Loeb LA., Nishimura S. Princess Takamatsu Symposium on DNA Repair and Human Cancers. Cancer Res; 70(11) June 1, 2010. [ pdf ]

Gorman et al. Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. J Mol Med (2010) 88:701-708. [ pdf ]

Publications 2009

Salk JJ, Fox EJ, Loeb LA .Mutational Heterogenity in Human Cancers: Origin and Consequences. Ann. Rev. Path. 2009 Sep 9 (52) : 51-75. [ pdf ]

Salk JJ, et al. Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci USA. 2009 Dec 19;106(40):20871-20876. [ pdf ]


Publications 2008

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr;40(4):392-4. [ pdf ]

Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD. The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer. J Biol Chem. 2008 Sep 5;283(36):24478-83. [ pdf ]

Loeb LA, Bielas JH, Beckman RA. Cancers Exhibit a Mutator Phenotype: Clinical Implications. Cancer Res. 2008 May 15;68(10):3551-7. [ pdf ]

Loeb LA, Monnat RJ Jr. DNA polymerases and human disease. Nat Rev Genet. 2008 Aug; 9(8):594-604. [ pdf ]

Chen CY, Guo HH, Shah D, Blank A, Samson LD, Loeb LA. Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst). 2008 Oct 1;7(10):1731-45. [ pdf ]

Loeb LA, Harris CC. Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res. 2008 Sep 1;68(17):6863-72. [ pdf ]

Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec;46(4):263-8. [ pdf ]

Publications 2007

Bielas JH, Venkatesan RN, Loeb LA. LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet. 2007 Apr;23(4):154-7. [ pdf ]

Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr;39(4):540-3. [ pdf ]

Loh E, Choe J, Loeb LA. Highly Tolerated Amino Acid Substitutions Increase the Fidelity of Escherichia Coli DNA Polymerase I. J Biol Chem. 2007 Apr 20;282(16):12201-9. [ pdf ]

Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA. Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci USA. 2007 Jun 19;104(25):10394-9. [ pdf ]

Loeb LA, Bielas JH. Limits to the Human Cancer Genome Project? Science. 2007 Feb 9;315(5813):762. [ pdf ]

Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA. Mutation at the Polymerase Active Site of Mouse DNA Polymerase delta Increases Genomic Instability and Accelerates Tumorigenesis. Mol Cell Biol. 2007 Nov;27(21):7669-82. [ pdf ]

Camps M, Herman A, Loh E, Loeb LA. Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):313-26. [ pdf ]

Publications 2006

Kamath-Loeb A, Loeb LA, Fry M. DNA Helicases and Human Disease. DNA Replication. 2006. Cold Spring Harbor Laboratory Press 0-87969-766-0. [ pdf ]

Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther. 2006 Jan;5(1):121-8. [ pdf ]

Hansen AB, Griner NB, Anderson JP, Kujoth GC, Prolla TA, Loeb LA, Glick E. Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity.
DNA Repair (Amst). 2006 Jan 5;5(1):71-9. [ pdf ]

Venkatesan RN, Bielas JH, Loeb LA. Generation of mutator mutants during carcinogenesis. DNA Repair (Amst). 2006 Mar 7;5(3):294-302. [ pdf ]

Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem. 2006 Feb 17;281(7):4486-94. [ pdf ]

Glick E, White LM, Elliott NA, Berg D, Kiviat NB, Loeb LA. Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Int J Cancer. 2006 Nov 1;119(9):2225-7. [ pdf ]

Beckman RA, Loeb LA. Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci USA. 2006 Sep 19;103(38):14140-5. [ pdf ]

Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA. Human cancers express a mutator phenotype. Proc Natl Acad Sci USA. 2006 Nov 28;103(48):18238-42. [ pdf ]

Publications 2005-2000

Kamath-Loeb AS, Loeb LA, Masuda Y, Hanaoka F. The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004. DNA Repair (Amst). 2005 Jun 8;4(6):740-7. [ pdf ]

Prehn RT, On the Nature of Cancer and Why Anticancer Vaccines Don't Work. Cancer Cell International. 2005 Aug 1;5(1):25. [ pdf ]

Bielas JH, Loeb LA. Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):206-13 [ pdf ]

Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec;46(4):263-8. [ pdf ]

Ozgenc A, Loeb LA. Current advances in unraveling the function of the Werner syndrome protein. Mutat Res. 2005 Jun 7. [ pdf ]

Beckman RA, Loeb LA. Negative clonal selection in tumor evolution. Genetics. 2005 Dec;171(4):2123-31 [ pdf ]

Beckman RA, Loeb LA. Genetic Instability in Cancer: Theory and Experiment. Semin Cancer Biol. 2005 Dec;15(6):423-35. [ pdf ]

Anderson JP, Angerer B, Loeb LA. Incorporation of reporter-labeled nucleotides by DNA polymerases. Biotechniques. 2005 Feb;38(2):257-64. [ pdf ]

Camps M, Loeb LA. Critical Role of R-loops in Processing Replication Blocks. Front Biosci. 2005 Jan 1;10:689-98. [ pdf ]

Bielas JH, Loeb LA. Mutator Phenotype in Cancer: Timing and Perspectives. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):206-13. [ pdf ]

Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem. 2006 Feb 17;281(7):4486-94. [ pdf ]

Loeb LA, Wallace DC, Martin GM. The Mitochondrial Thoery of Aging and its Relationship to Reactive Oxygen Species Damage and Somatic mtDNA Mutations.Proc Natl Acad Sci USA. 2005 Dec 27;102(52):18769-70. [ pdf ]

Loh E, Loeb LA. Mutability of DNA polymerase I: Implications For the Creation of Mutant DNA Polymerases. DNA Repair (Amst). 2005 Dec 8;4(12):1390-8. [ pdf ]

Bielas JH, Loeb LA. Quantification of random genomic mutations. Nat Methods. 2005 Apr;2(4):285-90. [ pdf ]

Venkatesan RN, Loeb LA. The Multiplicity of Mutations in Human Cancers. 2005. [ pdf ]

Smith RA, Loeb LA, Preston BD. Lethal mutagenesis of HIV. Virus Res. 2005 Feb;107(2):215-28. Review. [ pdf ]

Guo, H. H, J. Choe and L.A. Loeb. Protein tolerance to random amino acid change. Proc Natl Acad Sci USA., 2004. 101(25): p. 9205-10. [ pdf ]

Camps, M. and L.A. Loeb. When pol I goes into high gear: Processive DNA Synthesis by pol I in the Cell. Cell Cycle. 2004. 3(2): p. 116-8. [ pdf ]

Khateb S, Weisman-Shomer P, Hershco I, Loeb LA, Fry M. Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family. Nucleic Acids Res. 2004 Aug 9;32(14):4145-54. [ pdf ]

Kamath-Loeb AS, Welcsh P, Waite M, Adman ET, Loeb LA. The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem. 2004 Dec 31;279(53):55499-505. [ pdf ]

Blank, A., M.S. Bobola, B. Gold, S. Varadarajan, D.Kolstoe, E.H. Meade, P.S. Rabinovitch, L.A. Loeb, and J.R. Silber, The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst), 2004. 3(6): p.629-38. [ pdf ]

Sneeden JL, Loeb LA. Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. J Biol Chem. 2004 Sep 24;279(39):40723-8. [ pdf ]

Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol. 2004 Dec;14(6):473-86. Review. [ pdf ]

Camps, M. and L.A. Loeb. When pol I goes into high gear: Processive DNA Synthesis by pol I in the Cell. Cell Cycle., 2004. 3(2): p. 116-8. [ pdf ]

Martin, G.M., and L.A. Loeb. Aging: Mice and Mitochondria. Nature. 2004. 429(6990): p. 357-9. [ pdf ]

Guo, H. H, and L.A. Loeb. Tumbling down a different pathway to genetic instability. J Clin Invest., 2003. 112(12): p. 1793-5. [ pdf ]

Camps, M., and L.A. Loeb. Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods Mol Biol., 2003. 230: p. 8-11. [ pdf ]

Shen, J.C., and L.A. Loeb, Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site. J Biol Chem., 2003. 278(47): p. 46994-7001. [ pdf ]

Camps M., J. Naukkarinen, B.P. Johnson, and L.A. Loeb. Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci USA., 2003. 100(17): p. 9727-32. [ pdf ]

Shen J.C., Y. Lao, A. Kamath-Loeb, M.S. Wold, and L.A. Loeb. The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev., 2003. 124(8-9): p. 921-30. [ pdf ]

Glick, E., J.S. Chau, K.L. Vigna, S.D. McCulloch, E.T. Adman, T.A.Kunkel, and L.A. Loeb. Amino Acid Substitutions at Conserved Tyrosine 52 Alter Fidelity and Bypass Efficiency of Human DNA Polymerase eta. J Biol Chem., 2003. 278(21): p. 19341-6. [ pdf ]

Davidson, J.F., R. Fox, D.D. Harris, S. Lyons-Abbott, and L.A. Loeb. Insertion of the T3 DNA Polymerase Thioredoxin Binding Domain Enhances the Processivity and Fidelity of Taq DNA Polymerase. Nucleic Acids Res., 2003. 31(16): p. 4702-9. [ pdf ]

Loeb, L.A., K.R. Loeb, and J.P. Anderson. Multiple mutations and cancer. Proc Natl Acad Sci USA, 2003. 100(3): p. 776-81. [ pdf ]

Yang, Q., et al., The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem, 2002. 277(35): p. 31980-7. [ pdf ]

Kawate, H., D.M. Landis, and L.A. Loeb. Distribution of Mutations in Human Thymidylate Synthase Yielding Resistance to 5-fluorodeoxyuridine. J Biol Chem, 2002. 277(39): p. 36304-11. [ pdf ]

Glick, E., J.P. Anderson, and L.A. Loeb. In vitro production and screening of DNA polymerase eta mutants for catalytic diversity. Biotechniques, 2002. 33(5): p. 1136-42, 1144. [ pdf ]

Bergoglio, V., et al., Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res, 2002. 62(12): p. 3511-4. [ pdf ]

Davidson, J.F., H.H. Guo, and L.A. Loeb, Endogenous mutagenesis and cancer. Mutat Res, 2002. 509(1-2): p. 17-21. [ pdf ]

Glick, E., K.L. Vigna, and L.A. Loeb, Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. Embo J, 2001. 20(24): p. 7303-12. [ pdf ]

Shen, J. and L.A. Loeb, Unwinding the molecular basis of the Werner syndrome. Mech Ageing Dev. 2001. 122(9): p. 921-44. [ pdf ]

Skandalis, A. and L.A. Loeb, Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis. Nucleic Acids Res, 2001. 29(11): p. 2418-26. [ pdf ]

Patel, P.H. and L.A. Loeb, Getting a grip on how DNA polymerases function. Nat Struct Biol, 2001. 8(8): p. 656-9. [ pdf ]

Shinkai, A., P.H. Patel, and L.A. Loeb, The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable. J Biol Chem, 2001. 276(22): p. 18836-42. [ pdf ]

Shinkai, A. and L.A. Loeb, In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection. J Biol Chem, 2001. 276(50): p. 46759-64. [ pdf ]

Jackson, A.L. and L.A. Loeb, Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat Res, 2000. 447(2): p. 187-98. [ pdf ]

Suzuki, M., et al., Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix. J Biol Chem, 2000. 275(42): p. 32728-35. [ pdf ]

Uliel, L., et al., Human Ku antigen tightly binds and stabilizes a tetrahelical form of the Fragile X syndrome d(CGG)n expanded sequence. J Biol Chem, 2000. 275(42): p. 33134-41. [ pdf ]

Kamath-Loeb, A.S., et al., Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci USA, 2000. 97(9): p. 4603-8. [ pdf ]

Patel, P.H. and L.A. Loeb, DNA polymerase active site is highly mutable: evolutionary consequences. Proc Natl Acad Sci USA, 2000. 97(10): p. 5095-100. [ pdf ]

Kamath-Loeb, A.S., et al., Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci USA, 2000. 97(9): p. 4603-8. [ pdf ]

Shen, J.C. and L.A. Loeb, Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res, 2000. 28(17): p. 3260-8. [ pdf ]

Shen, J.C. and L.A. Loeb, The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. Trends Genet, 2000. 16(5): p. 213-20. [ pdf ]

Publications 1999-1995

Fry M, Loeb LA, Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG)n*, J. Biol. Chem. . pp. 12797–12802, 1999. [ pdf ]

Loeb LA, Essigmann JM, et al., Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proc. Natl. Acad. Sci. USA pp. 1492–1497 [ pdf ]

Abril N, Luque-Romero FL, et al., Human O6-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes. Carcinogenesis pp. 2089-2094, 1999. [ pdf ]

Encell LP, Landis DM, Loeb LA. Improving enzymes for cancer gene therapy. Bio Tech-Nature America [ pdf ]

Encell LP, Loeb LA. Redesigning the Substrate Specificity of Human O6-Alkylguanine-DNA-Alkyltransferase. Mutants with Enhanced Repair of O4-Methylthymine. American Chemical Society [ pdf ]

Newcomb TG, Allen KJ, Tkeshelashvili L, Loeb LA. Detection of tandem CC → TT mutations induced by oxygen radicals using mutation-specific PCR. Elsevier [ pdf ]

Spillare EA, Robles AI, et al., p-53 Mediated apoptosis is attenuated in Werner Syndrome cells. Genes and Development [ pdf ]

Jackson AL, Chen R, Loeb LA. Induction of microsatellite instability by oxidative DNA damage. Proc. Natl. Acad. Sci. USA pp. 12468–12473, October 1998. [ pdf ]

Rink SM, Shen JC, Loeb LA. Creation of RNA molecules that recognize the oxidative lesion 7, 8-dihydro-8-hydroxy-2’-deoxyguanosine (8-oxoG) in DNA. Proc. Natl. Acad. Sci. USA [ pdf ]

Landis DM, Loeb LA. Random Sequence Mutagenesis and Resistance to 5-Fluorouridine in Human Thymidylate Synthases* J. Biol. Chem. Issue of October 2, pp. 25809–25817, 1998. [ pdf ]

Shen JC, Gray MD, et al., Werner Syndrome Protein. J. Biol. Chem. Issue of December 18, pp. 34139–34144, 1998. [ pdf ]

Kamath AS, Shen JC, Loeb LA, Fry M. Werner Syndrome Protein. J. Biol. Chem. Issue of December 18, pp. 34145–34150, 1998. [ pdf ]

Davis BM, Encell LP, et al., Applied molecular evolution of O6-benzylguanineresistant DNA alkyltransferases in human hematopoietic cells. PNAS. [ pdf ]

Suzuki M, Avicola AK, Hoods L, Loeb LA. Low Fidelity Mutants in the O-Helix of Thermus aquaticus DNA Polymerase I* J. Biol. Chem. Issue of April 25, pp. 11228–11235, 1997. [ pdf ]

Kamath AS, Hizi A, Kasai H, Loeb LA. Incorporation of the Guanosine Triphosphate Analogs 8-Oxo-dGTP and 8-NH2-dGTP by Reverse Transcriptases and Mammalian DNA Polymerases* J. Biol. Chem. 1997, 892–898, 1997. [ pdf ]

Loeb LA. Transient Expression of a Mutator Phenotype in Cancer Cells. Science Mag. [ pdf ]

Black ME, Newcomb TG, Wilson HMP, Loeb LA. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc. Natl. Acad. Sci. USA. 1996, 93: 525–529. [ pdf ]

Kim, B. and L.A. Loeb, Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli. Proc Natl Acad Sci USA, 1996. 92(3): p. 684-8. [ pdf ]

Christians FC and Loeb LA. Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria. Proc Natl Acad Sci USA, 1996. 93: pp. 124–128. [ pdf ]

Suzuki M, Baskin D, Hood L, Loeb LA. Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sites in vivo with the crystal structure. Proc Natl Acad Sci USA, 1996. 93: pp. 670–675. [ pdf ]

Ji J, Clegg NJ, et al., In vitro expansion of GGC:GCC repeats: identification of the preferred strand of expansion. Oxford University Press. 1996, 24(14): 835-840. [ pdf ]

Key Publications prior to 1995

Blank A, Kim B, and Loeb L. DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae. Proc Natl Acad Sci USA., 1994. 91: pp. 9047-9051. [ pdf ]

Feig D.I., Sowers L.C., and Loeb L.A. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA. Proc Natl Acad Sci USA., 1994. 91: pp. 6609-6613. [ pdf ]

Fry M, and Loeb L.A. The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical struture. Proc Natl Acad Sci USA., 1994. 91: pp. 4950-4954. [ pdf ]

Ji J., and Loeb L. Fidelity of HIV-1 Reverse Transcriptase Copying a Hypervariable Region of the HIV-1 env gene Virology., 1994. 199: pp. 323-330. [ pdf ]