List of Publications
C.J. Cambier, K.K. Takaki, R.P. Larson, R.E. Hernandez, D.M. Tobin, K.B. Urdahl, C.L. Cosma, L. Ramakrishnan. 2014. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 505(7482):218-22.
L. Ramakrishnan. 2013. Looking within the zebrafish to understand the tuberculous granuloma. Adv Exp Med Biol 783:251-266.
J.D. Szumowski, K.N. Adams, P.H. Edelstein, and L. Ramakrishnan. 2012 Antimicrobial Efflux Pumps and Mycobacterium Tuberculosis Drug Tolerance: Evolutionary Considerations. Curr Top Microbiol Immunol. In process.
C.T. Yang, C.J. Cambier, J.M. Davis, C.J. Hall, P.S. Crosier, and L. Ramakrishnan. 2012. Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed From Infected Macrophages. Cell Host and Microbe: 12(3):301-12.
D.M. Tobin, F.J. Roca, S.F. Oh, R. McFarland, T.W. Vickery, J.P. Ray, D.C. Ko, Y. Zou, N.D. Bang, T.T. Chau, J.C. Vary, T.R. Hawn, S.J. Dunstan, J. J. Farrar, G.E. Thwaites, M.C. King, C.N. Serhan, L. Ramakrishnan. 2012. Host Genotype Directed Therapies can Optimize the Inflammatory Response to Mycobacterial Infections. Cell 148:434-46.
K.N. Adams, K.K Takaki, L.E. Connolly, H. Wiedenhoft, K. Winglee, O. Humbert, P.E. Edelstein, C.L. Cosma, L. Ramakrishnan. 2011. Drug Tolerance in Replicating Mycobacteria Induced by a Macrophage-Induced Efflux Mechanism. Cell, 145, 39-53
D. M. Tobin, J.C. Vary Jr, J.P. Ray, G.S. Walsh, S.J. Dunstan, N.D. Bang, D.A. Hagge, S. Khadge, M-C. King, T.R. Hawn, C.B. Moens, L. Ramakrishnan. The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans. 2010. Cell 140:717-730.
H. E. Volkman, T. C. Pozos, J. Zheng, J.M. Davis, J. F. Rawls, L. Ramakrishnan. 2010. Tuberculous granuloma induction via interactions of a bacterial secreted protein with host epithelium. Science, 327:466-469.
J.M. Davis, D. Haake*, L. Ramakrishnan*. 2009 Leptospira interrogans stably infects zebrafish in embryos, altering phagocyte behavior and homing to specific tissues. PLoS Neg Trop Dis, 3:e463. *Joint corresponding authors.
M. Brannon, J. M. Davis, C. Hall, P. Crozier, J. R. Mathias, A. Huttenlocher, L. Ramakrishnan* and S. Moskowitz*. 2009. Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol, 11:755-768. *Joint corresponding authors.
C.L. Cosma, O. Humbert, D.R. Sherman. L. Ramakrishnan. 2008. Trafficking of Superinfecting Mycobacterium into Established Granulomas Occurs in Mammals and is Independent of the Mycobacterial Erp and ESX-1/RD1 Virulence Loci. J Infect Dis, 198:1851-5.
H. Clay, H.E. Volkman and L. Ramakrishnan. 2008. TNF signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death but is not required for tuberculous granuloma formation. Immunity 29:283-294.
T.P. Stinear, T. Seemann, P.F. Harrison, G.A. Jenkin, J.K. Davies, P.D.R. Johnson, Z. Abdellah, C. Arrowsmith, T. Chillingworth, C. Churcher, K. Clarke, A. Cronin, P. Davis, I. Goodhead N. Holroyd, K. Jagels, A. Lord, S. Moule, K. Mungall, H. Norbertczak, M.A. Quail, E. Rabbinowitsch, D. Walker, B. White, S. Whitehead, P.L.C. Small, R. Brosch, L. Ramakrishnan, M.A. Fischbach, J. Parkhill and S.T. Cole. 2008. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res 18:729-741.
H. Clay, J.M. Davis, D. Beery, A. Huttenlocher, S. E. Lyons and L. Ramakrishnan. 2007. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host and Microbe 2:29-39.
L.E. Swaim, L.E. Connolly, H.E. Volkman, O. Humbert, D. E. Born, and L. Ramakrishnan. 2006. Mycobacterium marinum infection of adult zebrafish produces caseating granulomatous tuberculosis and is moderated by adaptive immunity. Infect Immun 74:6108-17.
C. L. Cosma, K. Klein, R. Kim, D. Beery, and L. Ramakrishnan. 2006 Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect Immun 74:3125-3133.
J.M. Davis, H. Clay, J.L. Lewis, N. Ghori, P. Herbomel and L. Ramakrishnan. 2002. Real-time visualization of Mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity 17:693-702.
K. Chan, T. Knaak, L. Satkamp, O.Humbert, S. Falkow and L. Ramakrishnan. 2002. Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci USA 99:3920-3925.
L. Ramakrishnan, H.T. Tran, N.A. Federspiel and S. Falkow. 1997. A crtB homologue essential for photochromogenicity in Mycobacterium marinum: isolation, characterization and gene disruption via homologous recombination. J Bacteriol 179: 5862-5868.
L. Ramakrishnan, R. H. Valdivia, J. McKerrow and S. Falkow. 1997. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Imm 65:767-773.
L. Ramakrishnan, Q. Wu, A. Yu, M.D. Cooper and N. Rosenberg. 1990. BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential. J Immunol 145:1603-1608.
J.M. Davis and L. Ramakrishnan. 2009. The zebrafish as a model for studying phagocyte-pathogen interactions in vivo. In The multiple faces of the phagocyte. ASM press. Eds. S. Gordon and D. Russell.
C. L. Cosma, J. M. Davis, L. E. Swaim, H. Volkman, and L. Ramakrishnan. 2006. Zebrafish and Frog Models of Mycobacterium marinum Infection. Curr Prot Microbiol, 10B.2.1-10B.2.33. John Wiley and Sons Inc.
R.H. Valdivia and L. Ramakrishnan. 2000. Applications of GFP gene fusions and flow cytometry to the study of bacterial gene expression in host cells. In Methods in Enzymology, Academic Press, San Diego, CA. Eds. J.N. Abelson, S.D. Emr and J. Thorner. 326, 47-73.
L. Ramakrishnan and S. Falkow. 1999 Pathogen strategies: A hitchhiker’s guide to the macrophage. In Advances in Cell and Molecular Biology of Membranes and Organelles. Vol. 6, pp 1-25. Ed. S. Gordon, JAI Press Inc. Greenich CT.