Hello, and welcome to the official Miller Lab website! Our lab is in the Department of Biochemistry at the University of Washington School of Medicine. Thanks for visiting – please take some time to learn more about our group and our research to understand how cells and organisms respond when oxygen (O2) is limited. This condition, known as hypoxia, can occur when blood flow to tissues is disrupted due to traumatic injury, stroke, or heart attack. We want to figure out how to keep cells (and whole animals) alive when they experience hypoxia. We are also interested in learning how to use the response to hypoxia to treat diseases like cancer and diabetes, where cells act like they are hypoxic even when there is plenty of O2 around. One focus of our lab is understanding the protective effects of hydrogen sulfide (H2S). H2S treatment can improve survival in mammals when blood flow is disrupted, but we don’t understand how it works – yet. This has limited the use of H2S clinically. You can read more about our research here. We hope you will also check out our lab blog and follow us on twitter.

We are always interested in recruiting clever and enthusiastic young scientists to our group. No matter what stage in your career, undergraduate through postdoctoral, find important information about applying to join our team here.

young C. elegans larvae expressing green fluorescent protein (GFP) in M-lineage cells.
Micrograph taken by Dana Miller

The mighty worm, C. elegans
They may be small, but the nematode Caenorhabditis elegans is no lightweight! Two Nobel Prizes have been awarded for research to understand how these tiny metazoans work. The worm is a favorite model system in the Miller Lab, because of its powerful molecular, cellular and genetic tools. You can learn more about these awesome little critters at Wormbase, or read this excellent blog post by our very own graduate student Emily. If you have questions, feel free to comment over our blog.

Science and the Public
One goal in the Miller Lab is to communicate our science to the public. Please take a moment to check out our blog, A Breath of Fresh Air, where we talk about important and fun science for a general audience. And follow us on twitter – where we chat about science and other important Seattle events.