Studies - The University of Washington Virology Research Clinic

Enrolling Studies ☎ Call 206-520-4340* now to see if you're eligible!* Not seeing a study? Find more opportunities at the NIH's Clinical Trials website.
Shingles (Varicella Zoster Virus)
Shingrix Vaccination and Immune Response To learn more about the body’s immune response to the FDA-approved Shingles vaccine
Natural History
The Menstrual Cycle Study Studying the impact of the menstrual cycle on granulysin-mediated immunity in the human cervicovaginal tract

Ongoing Studies Patients are still being seen for these studies, but we are no longer enrolling new patients* into them.*
Genital HSV-2
Genital Herpes and Immune Memory Study Harnessing Tissue Resident Memory T Cells for Immunotherapy of Herpes Virus Infections	HSV and HIV Tissue Reservoirs Study To understand whether immune responses to HSV-2 bring HIV infected cells to the genital tract in men and women with HIV infection
Mpox
Monkeypox Vaccination & Immune Response	Immune Response following MPOX Infection
Human Papillomavirus (HPV)
The VIVA Trial HPV Vaccine to Interrupt Progression of Vulvar and Anal Neoplasia	Immunogenicity of fractional dose of the HPV vaccines To determine if a fractional dose of the HPV vaccine produces a detectable immune response
Coronavirus
Novavax COVID-19 Vaccine Trial Testing the SARS-CoV-2 recombinant spike protein nanoparticle vaccine	Mix 'n Match A Phase 1/2 Study of Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) after Receipt of EUA Vaccines	COVAIL Trial: Help Fight What's Next Phase 2 Additional COVID-19 Vaccine Booster Trial
Gritstone COVID-19 Vaccine Clinical Trial Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults
Human Immunodeficiency Virus (HIV)
HSV and HIV Tissue Reservoirs Study To understand whether immune responses to HSV-2 bring HIV infected cells to the genital tract in men and women with HIV infection	Immunity Study Find out whether factors in the genital area of the body can change how your body fights HIV

Complete Studies This is a collection of research studies and clinical trials that we have conducted in the past but are no longer enrolling* in.*
Genital HSV-2
Genital Herpes (HSV-2) Therapeutic Vaccine Trial (Genocea GEN-003)	Genital Herpes (HSV-2) Therapeutic Vaccine Trial (Vical, Inc.) Phase 2 Trial to Evaluate the Safety and Efficacy of HSV-2 Therapeutic DNA Vaccine (Placebo-Controlled)	Cervical T-Cell Response to HSV To correlate our assays of cervical cellular immune response to HSV with the amount of HSV shedding in the genital tract.
Genital Herpes (HSV-2) Vaccine Study (Sanofi HSV529)	Integrated Human Immune Response to HSV-2 A study involving multiple biopsies	A Phase 1/2a HSV-2 Vaccine Study: Genocea Genocea
Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection Investigate if a maintenance dose of GEN-003 reduces the number of days that subjects have a genital herpes recurrence.	Interaction between HSV‐2 and the vaginal microbiome in the female genital tract Studying the interaction betwen herpes simplex virus type-2 and bacterial vaginosis in the female genital tract.	Long-term Follow-up of GEN-003-002 Subjects for Efficacy and Immunogenicity Evaluating the long-term efficacy and immunogenicity of GEN-003 in subjects with genital HSV-2 infection.
A Cross-Over Trial Comparing AiCuris and Valacyclovir AiCuris	GEN-003 Phase II Dosing Study: Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine A Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Varying Combinations of GEN-003 and Matrix-M2 in Subjects with Genital HSV-2 Infection	An Investigational Phase 1/2 HSV-2 Therapeutic Vaccine: Vical This study is on an HSV-2 therapeutic vaccine
Effect of Tenofovir on Genital HSV Shedding Tenofovir & HSV-2
Mpox
New Investigational Smallpox Vaccine: Imvamune^® Comparison of Lyophilized Imvamune versus Liquid Formulation Imvamune
Shingles (Varicella Zoster Virus)
Immune Response to Shingles Vaccination In this study we hope to learn more about the body’s immune response to the shingles vaccine.	Immune Response to Shingles Rash In this study we hope to learn more about the body’s natural immune response to the shingles rash.
Human Papillomavirus (HPV)
HPV Immune Response and the Gardasil Vaccine Clonal analysis of B cell repertoires following Gardasil vaccination or HPV infection
Coronavirus
COVID-19 PEP Study Post-Exposure Prophylactic Drug Trial for the Treatment of COVID-19	COVID-19 Plasma Donation Study Plasma donors sought among recovered COVID-19 patients	COVID-19 Treatment Study: Hydroxychloroquine & Azithromycin Treatment for SARS-CoV-2 in High-risk Adult Outpatients
Human Immunodeficiency Virus (HIV)
H1N1 Flu Vaccine: Two Dose Levels in HIV positive volunteers Comparing the safety and efficacy of two dose levels in HIV-positive volunteers
Genital HSV-1
Immunologic and Virologic Characterization of First Episode Genital HSV-1 Infection To understand the natural history of genital HSV-1 in persons who recently acquired genital HSV-1.
Cytomegalovirus (CMV)
CMV Reactivation and Immunosenescence Breast milk study on CMV	CMV Status and Vaccine Response Quantifying the difference of efficacy of the Hepatitis B vaccine series in CMV positive and CMV negative individuals.	CMV Test Comparison Compare Diagnostic Tests for Diagnosis of Primary CMV Infection
Bacterial Vaginosis (BV)
Interaction between HSV‐2 and the vaginal microbiome in the female genital tract Studying the interaction betwen herpes simplex virus type-2 and bacterial vaginosis in the female genital tract.	New Treatment for BV and Yeast A Randomized Single Blind Safety and Efficacy Study of a New Treatment for Vaginitis (BV and/or VVC)	NuvaRing's Effects on BV Effects of a vaginal contraceptive ring on vaginal microbiota and local immunity
Microbial Dynamics in the Human Vagina The purpose of this study is to understand more about the bacteria that cause BV and what factors might make a woman more likely to get BV.
Influenza
H1N1 Flu Vaccine: Two Dose Levels in HIV positive volunteers Comparing the safety and efficacy of two dose levels in HIV-positive volunteers	H1N1 Flu Vaccine: High/Low Dose Without Adjuvant A study to compare the safety and efficacy of high and low doses of H1N1 vaccine.
Malaria
Infection-Treatment-Vaccination for Plasmodium falciparum Malaria

Archived Studies
Oral HSV-1
Local and Systemic Cellular Immunity to HSV Type 1 HSV Type 1