Human Photonics Laboratory

Scanning Fiber Endoscope Projects

Scanning Fiber Endoscope Projects

Ultrathin and flexible scanning fiber endoscope (SFE) for the early detection and treatment of cancers within the body. The goal is to advance minimally invasive medical imaging by using ultrathin flexible endoscopes that allow access to regions of the body that were previously inaccessible. Once at a region of interest, imaging, diagnosis, therapy, and monitoring can be performed from the SFE with the goal of earlier and less-invasive treatment of cancers before they have spread from their place of origin. To improve our chances of survival from cancer, the diseased tissue must be detected and treated early, often before the person has any symptoms.

The main attributes of the SFE technology are:

  • High-resolution imaging within an ultrathin size (less than 2 mm in diameter)
  • Integrated optical diagnoses and laser therapies with full-color imaging
  • Low-cost components that may lead to a disposable distal (in vivo) end
  • Highly flexible & durable shaft that imparts less pressure on tissues
  • Efficient laser scanning imaging that allows 3D imaging for future surgeries
  • Computer-tracked guidance system for complex branching systems like the lung

Active research is in the following areas:

  • Microscanner Dynamics and Control
  • Unsedated Tethered-Capsule Endoscopy (TCE) of the Esophagus
  • Active Steering and Surface Scanning of the Bladder
  • Guidance System for Ultrathin Bronchsocopy in the Peripheral Lung
  • Image-Guided Site Selection for Biopsy
  • Small Duct Cancer Surveillance
  • Scanning Fiber 3D Endomicroscopies
  • Multispectral Fluorescence Endoscopy
  • Fluorescence Guided Robotic Surgery

Funding acknowledgments:

Publications

The following HPL publications are related to this research area:

2014

  • Y. Gong, R. S. Johnston, D. C. Melville, and E. J. Seibel, “Axial-stereo 3D optical metrology of internally machined parts using high-quality imaging from a scanning laser endoscope,” in International symposium on optomechatronic technologies (isot), 2014, pp. 6-9.
    [Bibtex]
    @inproceedings{Gong2014,
    author = {Gong, Yuanzheng and Johnston, Richard S and Melville, C David and Seibel, Eric J},
    booktitle = {International Symposium on Optomechatronic Technologies (ISOT)},
    keywords = {3d optical metrology,axial-stereo,internal,machine vision,non-contact inspection,scanning laser,surface},
    mendeley-groups = {HPL,HPL/SFE\_3D\_metrology},
    pages = {6--9},
    title = {{Axial-stereo 3D optical metrology of internally machined parts using high-quality imaging from a scanning laser endoscope}},
    year = {2014}
    }
  • [DOI] Y. Gong, T. D. Soper, V. W. Hou, D. Hu, B. Hannaford, and E. J. Seibel, “Mapping surgical fields by moving a laser-scanning multimodal scope attached to a robot arm,” Medical imaging 2014: image-guided procedures, robotic interventions, and modeling, vol. 9036, p. 90362S, 2014.
    [Bibtex]
    @article{Gong2014a,
    author = {Gong, Yuanzheng and Soper, Tomothy D. and Hou, Vivian W. and Hu, Danying and Hannaford, Blake and Seibel, Eric J.},
    doi = {10.1117/12.2044165},
    editor = {Yaniv, Ziv R. and Holmes, David R.},
    journal = {Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling},
    keywords = {3d surface mosaic,fluorescence-guided surgery,image-guided therapy,machine vision,medical robotics},
    mendeley-groups = {HPL/SFE\_surgery\_guidance},
    month = mar,
    pages = {90362S},
    title = {{Mapping surgical fields by moving a laser-scanning multimodal scope attached to a robot arm}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2044165},
    volume = {9036},
    year = {2014}
    }
  • [DOI] V. W. Hou, C. Yang, L. Y. Nelson, and E. J. Seibel, “The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm,” in Design and perfomance validation of phantoms used in conjuction with optical measurement of tissue vi, 2014, p. 894506.
    [Bibtex]
    @inproceedings{Hou2014,
    author = {Hou, Vivian W. and Yang, Chenying and Nelson, Leonard Y. and Seibel, Eric J.},
    booktitle = {Design and Perfomance Validation of Phantoms Used in Conjuction with Optical Measurement of Tissue VI},
    doi = {10.1117/12.2040167},
    editor = {Nordstrom, Robert J. and Bouchard, Jean-Pierre and Allen, David W.},
    keywords = {autofluorescence mitigation,collagen,endoscope,esophageal adenocarcinoma,evaluation of an autofluorescence,fluorescence,for the,mitigation algorithm,optical phantom,scanning fiber,simplified epithelial tissue phantom,the development of a},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = mar,
    pages = {894506},
    title = {{The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2040167},
    volume = {8945},
    year = {2014}
    }
  • [DOI] P. Z. McVeigh, R. Sacho, R. a Weersink, V. M. Pereira, W. Kucharczyk, E. J. Seibel, B. C. Wilson, and T. Krings, “High-resolution angioscopic imaging during endovascular neurosurgery.,” Neurosurgery, vol. 75, iss. 2, p. 171–80; discussion 179–80, 2014.
    [Bibtex]
    @article{McVeigh2014,
    author = {McVeigh, Patrick Z and Sacho, Raphael and Weersink, Robert a and Pereira, Vitor M and Kucharczyk, Walter and Seibel, Eric J and Wilson, Brian C and Krings, Timo},
    doi = {10.1227/NEU.0000000000000383},
    isbn = {0000000000000},
    issn = {1524-4040},
    journal = {Neurosurgery},
    keywords = {angioscopy,cerebral vasculature,coiling,endoscopy,endovascular therapy,flow diverter},
    mendeley-groups = {HPL,HPL/SFE\_small\_lumen\_imaging},
    month = aug,
    number = {2},
    pages = {171--80; discussion 179--80},
    pmid = {24762703},
    title = {{High-resolution angioscopic imaging during endovascular neurosurgery.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4086773\&tool=pmcentrez\&rendertype=abstract},
    volume = {75},
    year = {2014}
    }
  • [DOI] A. W. Templeton, K. Webb, J. H. Hwang, E. J. Seibel, and M. Saunders, “Scanning fiber endoscopy: a novel platform for cholangioscopy.,” Gastrointestinal endoscopy, vol. 79, iss. 6, pp. 1000-1, 2014.
    [Bibtex]
    @article{Templeton2014,
    author = {Templeton, Adam W and Webb, Kevin and Hwang, Joo Ha and Seibel, Eric J and Saunders, Michael},
    doi = {10.1016/j.gie.2013.12.005},
    issn = {1097-6779},
    journal = {Gastrointestinal endoscopy},
    mendeley-groups = {HPL/SFE\_small\_lumen\_imaging},
    month = jun,
    number = {6},
    pages = {1000--1},
    pmid = {24462166},
    publisher = {Elsevier},
    title = {{Scanning fiber endoscopy: a novel platform for cholangioscopy.}},
    url = {http://www.ncbi.nlm.nih.gov/pubmed/24462166},
    volume = {79},
    year = {2014}
    }
  • [DOI] M. Timoshchuk, L. Zhang, B. a. Dickinson, J. S. Ridge, A. S. Kim, C. T. Baltuck, L. Y. Nelson, J. H. Berg, and E. J. Seibel, “Guided fluorescence diagnosis of childhood caries: preliminary measures correlate with depth of carious decay,” in Lasers in dentistry xx, 2014, p. 892904.
    [Bibtex]
    @inproceedings{Timoshchuk2014,
    author = {Timoshchuk, Mari-Alina and Zhang, Liang and Dickinson, Brian a. and Ridge, Jeremy S. and Kim, Amy S. and Baltuck, Camille T. and Nelson, Leonard Y. and Berg, Joel H. and Seibel, Eric J.},
    booktitle = {Lasers in Dentistry XX},
    doi = {10.1117/12.2041648},
    editor = {Rechmann, Peter and Fried, Daniel},
    keywords = {autofluorescence,dental caries,image-guided diagnosis,laser-induced fluorescence spectroscopy,optical biopsy,pilot clinical study,scanning fiber endoscope,spectral analysis},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = feb,
    pages = {892904},
    title = {{Guided fluorescence diagnosis of childhood caries: preliminary measures correlate with depth of carious decay}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2041648},
    volume = {8929},
    year = {2014}
    }
  • [DOI] C. Yang, V. W. Hou, L. Y. Nelson, R. S. Johnston, D. C. Melville, and E. J. Seibel, “Multi-spectral scanning fiber endoscope with concurrent autofluorescence mitigation for enhanced target-to-background ratio imaging,” in Endoscopic microscopy ix, 2014, p. 89270I.
    [Bibtex]
    @inproceedings{Yang2014,
    author = {Yang, Chenying and Hou, Vivian W. and Nelson, Leonard Y. and Johnston, Richard S. and Melville, C. David and Seibel, Eric J.},
    booktitle = {Endoscopic Microscopy IX},
    doi = {10.1117/12.2038553},
    editor = {Suter, Melissa J. and Lam, Stephen and Brenner, Matthew and Tearney, Guillermo J. and Wang, Thomas D.},
    keywords = {autofluorescence,fluorescein,fluorescence,molecular diagnostic imaging,multi-,multi-modal imaging,scanning fiber endoscope,spectral imaging,target-to-background ratio,wide-field endoscopy},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = mar,
    pages = {89270I},
    title = {{Multi-spectral scanning fiber endoscope with concurrent autofluorescence mitigation for enhanced target-to-background ratio imaging}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2038553},
    volume = {8927},
    year = {2014}
    }
  • C. Yang, V. W. Hou, E. J. Girard, L. Y. Nelson, and E. J. Seibel, “Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging Target-to-background enhancement in multispectral endoscopy with background autofluorescence,” Journal of biomedical optics, vol. 19, iss. 7, p. 076014–1–16, 2014.
    [Bibtex]
    @article{Yang2014a,
    author = {Yang, Chenying and Hou, Vivian W and Girard, Emily J and Nelson, Leonard Y and Seibel, Eric J},
    journal = {Journal of biomedical optics},
    keywords = {autofluorescence,cancer detection,contrast,flexible endoscopy,fluorescein,fluorescence,molecular diagnostic imaging,multispectral imaging,real-time imaging,scanning fiber endo-,scope,target-to-background ratio,wide-field fluorescence imaging},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    number = {7},
    pages = {076014--1--16},
    title = {{Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging Target-to-background enhancement in multispectral endoscopy with background autofluorescence}},
    volume = {19},
    year = {2014}
    }
  • [DOI] P. Deladurantaye, A. Paquet, C. Paré, H. Zheng, M. Doucet, D. Gay, M. Poirier, J. Cormier, O. Mermut, B. C. Wilson, and E. J. Seibel, “Advances in engineering of high contrast CARS imaging endoscopes,” Optics express, vol. 22, iss. 21, p. 25053, 2014.
    [Bibtex]
    @article{Deladurantaye2014,
    author = {Deladurantaye, Pascal and Paquet, Alex and Par\'{e}, Claude and Zheng, Huimin and Doucet, Michel and Gay, David and Poirier, Michel and Cormier, Jean-Fran\c{c}ois and Mermut, Ozzy and Wilson, Brian C. and Seibel, Eric J.},
    doi = {10.1364/OE.22.025053},
    issn = {1094-4087},
    journal = {Optics Express},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs},
    month = oct,
    number = {21},
    pages = {25053},
    title = {{Advances in engineering of high contrast CARS imaging endoscopes}},
    url = {http://www.opticsinfobase.org/abstract.cfm?URI=oe-22-21-25053},
    volume = {22},
    year = {2014}
    }

2013

  • [DOI] S. U. Tran, J. S. Ridge, L. Y. Nelson, and E. J. Seibel, “Laser investigation of the non-uniformity of fluorescent species in dental enamel,” in Lasers in dentistry xix, 2013, p. 85660L.
    [Bibtex]
    @inproceedings{Tran2013,
    author = {Tran, Stephanie U. and Ridge, Jeremy S. and Nelson, Leonard Y. and Seibel, Eric J.},
    booktitle = {Lasers in Dentistry XIX},
    doi = {10.1117/12.2002519},
    editor = {Rechmann, Peter and Fried, Daniel},
    keywords = {autofluorescence,enamel,ii erosion,interprismatic,prismatic,type i and type},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = mar,
    pages = {85660L},
    title = {{Laser investigation of the non-uniformity of fluorescent species in dental enamel}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2002519},
    volume = {8566},
    year = {2013}
    }
  • [DOI] C. Yang, V. Hou, L. Y. Nelson, and E. J. Seibel, “Color-matched esophagus phantom for fluorescent imaging,” in Design and performance validation of phantoms used in conjuction with optical measurement of tissue v, 2013, p. 85830F.
    [Bibtex]
    @inproceedings{Yang2013a,
    author = {Yang, Chenying and Hou, Vivian and Nelson, Leonard Y. and Seibel, Eric J.},
    booktitle = {Design and Performance Validation of Phantoms Used in Conjuction with Optical Measurement of Tissue V},
    doi = {10.1117/12.2000834},
    editor = {Nordstrom, Robert J.},
    keywords = {barrett,distance compensation,fluorescence,fluorescence quantification,imaging,molecular,phantoms,s esophagus,scanning fiber endoscope,tissue color},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = feb,
    pages = {85830F},
    title = {{Color-matched esophagus phantom for fluorescent imaging}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2000834},
    volume = {8583},
    year = {2013}
    }
  • [DOI] C. Yang, V. Hou, L. Y. Nelson, and E. J. Seibel, “Color-matched and fluorescence-labeled esophagus phantom and its applications.,” Journal of biomedical optics, vol. 18, iss. 2, p. 26020, 2013.
    [Bibtex]
    @article{Yang2013b,
    abstract = {We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed "hot-spot" locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2 mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.},
    author = {Yang, Chenying and Hou, Vivian and Nelson, Leonard Y and Seibel, Eric J},
    doi = {10.1117/1.JBO.18.2.026020},
    issn = {1560-2281},
    journal = {Journal of biomedical optics},
    keywords = {Algorithms,Color,Esophagoscopy,Esophagoscopy: instrumentation,Esophagoscopy: methods,Esophagoscopy: statistics \& numerical data,Esophagus,Fluorescent Dyes,Humans,Latex,Molecular Imaging,Molecular Imaging: instrumentation,Molecular Imaging: methods,Molecular Imaging: statistics \& numerical data,Optical Fibers,Optical Phenomena,Phantoms, Imaging},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = feb,
    number = {2},
    pages = {26020},
    pmid = {23403908},
    title = {{Color-matched and fluorescence-labeled esophagus phantom and its applications.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3569733\&tool=pmcentrez\&rendertype=abstract},
    volume = {18},
    year = {2013}
    }
  • [DOI] C. Yang, V. Hou, L. Y. Nelson, and E. J. Seibel, “Mitigating fluorescence spectral overlap in wide-field endoscopic imaging.,” Journal of biomedical optics, vol. 18, iss. 8, p. 86012, 2013.
    [Bibtex]
    @article{Yang2013c,
    abstract = {The number of molecular species suitable for multispectral fluorescence imaging is limited due to the overlap of the emission spectra of indicator fluorophores, e.g., dyes and nanoparticles. To remove fluorophore emission cross-talk in wide-field multispectral fluorescence molecular imaging, we evaluate three different solutions: (1) image stitching, (2) concurrent imaging with cross-talk ratio subtraction algorithm, and (3) frame-sequential imaging. A phantom with fluorophore emission cross-talk is fabricated, and a 1.2-mm ultrathin scanning fiber endoscope (SFE) is used to test and compare these approaches. Results show that fluorophore emission cross-talk could be successfully avoided or significantly reduced. Near term, the concurrent imaging method of wide-field multispectral fluorescence SFE is viable for early stage cancer detection and localization in vivo. Furthermore, a means to enhance exogenous fluorescence target-to-background ratio by the reduction of tissue autofluorescence background is demonstrated.},
    author = {Yang, Chenying and Hou, Vivian and Nelson, Leonard Y and Seibel, Eric J},
    doi = {10.1117/1.JBO.18.8.086012},
    issn = {1560-2281},
    journal = {Journal of biomedical optics},
    keywords = {Algorithms,Artifacts,Endoscopy,Endoscopy: methods,Image Enhancement,Image Enhancement: methods,Image Interpretation, Computer-Assisted,Image Interpretation, Computer-Assisted: methods,Microscopy, Fluorescence, Multiphoton,Microscopy, Fluorescence, Multiphoton: methods,Reproducibility of Results,Sensitivity and Specificity},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = aug,
    number = {8},
    pages = {86012},
    pmid = {23966226},
    title = {{Mitigating fluorescence spectral overlap in wide-field endoscopic imaging.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3767456\&tool=pmcentrez\&rendertype=abstract},
    volume = {18},
    year = {2013}
    }
  • [DOI] C. Yang, T. D. Soper, and E. J. Seibel, “Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging,” in Endoscopic microscopy viii, 2013, p. 857508.
    [Bibtex]
    @inproceedings{Yang2013,
    author = {Yang, Chenying and Soper, Timothy D. and Seibel, Eric J.},
    booktitle = {Endoscopic Microscopy VIII},
    doi = {10.1117/12.2002219},
    editor = {Tearney, Guillermo J. and Wang, Thomas D.},
    keywords = {barrett,fluorescence imaging,hot-spots detection,mosaicking,multimodal imaging,s esophagus,scanning fiber endoscope},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = mar,
    pages = {857508},
    title = {{Detecting fluorescence hot-spots using mosaic maps generated from multimodal endoscope imaging}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2002219},
    volume = {8575},
    year = {2013}
    }
  • [DOI] L. Zhang, A. S. Kim, J. S. Ridge, L. Y. Nelson, J. H. Berg, and E. J. Seibel, “Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy : clinical prototype laser light scanning and fluorescence spectroscopy :,” Journal of biomedical optics, vol. 18, iss. 11, p. 111412–1 — 111412–8, 2013.
    [Bibtex]
    @article{Zhang2013a,
    author = {Zhang, Liang and Kim, Amy S and Ridge, Jeremy S and Nelson, Leonard Y and Berg, Joel H and Seibel, Eric J},
    doi = {10.1117/1.JBO.18},
    journal = {Journal of biomedical optics},
    keywords = {12,13,2013,26,28,accepted for publication jul,autofluorescence,caries detection,clinical prototype,laser-induced fluorescence,light,multimodal device,near-ultraviolet,online aug,paper 130284sspr received apr,published,revised manuscript received jun,scanning fiber endoscope,scattering},
    mendeley-groups = {HPL,HPL/SFE dental},
    number = {11},
    pages = {111412--1 -- 111412--8},
    title = {{Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy : clinical prototype laser light scanning and fluorescence spectroscopy :}},
    volume = {18},
    year = {2013}
    }
  • L. Zhang, J. S. Ridge, L. Y. Nelson, A. S. Kim, J. H. Berg, and E. J. Seibel, Tri-modal Optical Device for Detection of Early Childhood Caries, 2013.
    [Bibtex]
    @misc{Zhang2013,
    author = {Zhang, Liang and Ridge, Jeremy S and Nelson, Leonard Y and Kim, Amy S and Berg, Joel H and Seibel, Eric J},
    mendeley-groups = {HPL,HPL/SFE dental},
    pages = {Poster Number 1807},
    title = {{Tri-modal Optical Device for Detection of Early Childhood Caries}},
    year = {2013}
    }

2012

  • [DOI] B. P. Joshi, S. J. Miller, C. M. Lee, E. J. Seibel, and T. D. Wang, “Multispectral endoscopic imaging of colorectal dysplasia in vivo.,” Gastroenterology, vol. 143, iss. 6, pp. 1435-7, 2012.
    [Bibtex]
    @article{Joshi2012,
    author = {Joshi, Bishnu P and Miller, Sharon J and Lee, Cameron M and Seibel, Eric J and Wang, Thomas D},
    doi = {10.1053/j.gastro.2012.08.053},
    issn = {1528-0012},
    journal = {Gastroenterology},
    keywords = {Adenoma,Adenoma: diagnosis,Adenoma: pathology,Colorectal Neoplasms,Colorectal Neoplasms: diagnosis,Colorectal Neoplasms: pathology,Diagnostic Imaging,Diagnostic Imaging: methods,Endoscopy, Gastrointestinal,Endoscopy, Gastrointestinal: methods,Humans,Optical Imaging,Optical Imaging: methods,Video Recording},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = dec,
    number = {6},
    pages = {1435--7},
    pmid = {23041325},
    publisher = {Elsevier Inc.},
    title = {{Multispectral endoscopic imaging of colorectal dysplasia in vivo.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3547605\&tool=pmcentrez\&rendertype=abstract},
    volume = {143},
    year = {2012}
    }
  • [DOI] S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy.,” Journal of biomedical optics, vol. 17, iss. 2, p. 21103, 2012.
    [Bibtex]
    @article{Miller2012,
    abstract = {Gastrointestinal cancers are heterogeneous and can overexpress several protein targets that can be imaged simultaneously on endoscopy using multiple molecular probes. We aim to demonstrate a multispectral scanning fiber endoscope for wide-field fluorescence detection of colonic dysplasia. Excitation at 440, 532, and 635 nm is delivered into a single spiral scanning fiber, and fluorescence is collected by a ring of light-collecting optical fibers placed around the instrument periphery. Specific-binding peptides are selected with phage display technology using the CPC;Apc mouse model of spontaneous colonic dysplasia. Validation of peptide specificity is performed on flow cytometry and in vivo endoscopy. The peptides KCCFPAQ, AKPGYLS, and LTTHYKL are selected and labeled with 7-diethylaminocoumarin-3-carboxylic acid (DEAC), 5-carboxytetramethylrhodamine (TAMRA), and CF633, respectively. Separate droplets of KCCFPAQ-DEAC, AKPGYLS-TAMRA, and LTTHYKL-CF633 are distinguished at concentrations of 100 and 1 $\mu$M. Separate application of the fluorescent-labeled peptides demonstrate specific binding to colonic adenomas. The average target/background ratios are 1.71 ± 0.19 and 1.67 ± 0.12 for KCCFPAQ-DEAC and AKPGYLS-TAMRA, respectively. Administration of these two peptides together results in distinct binding patterns in the blue and green channels. Specific binding of two or more peptides can be distinguished in vivo using a novel multispectral endoscope to localize colonic dysplasia on real-time wide-field imaging.},
    author = {Miller, Sharon J and Lee, Cameron M and Joshi, Bishnu P and Gaustad, Adam and Seibel, Eric J and Wang, Thomas D},
    doi = {10.1117/1.JBO.17.2.021103},
    issn = {1560-2281},
    journal = {Journal of biomedical optics},
    keywords = {Adenocarcinoma,Adenocarcinoma: pathology,Animals,Cell Line, Tumor,Colonic Neoplasms,Colonic Neoplasms: pathology,Endoscopes, Gastrointestinal,Equipment Design,Equipment Failure Analysis,Fiber Optic Technology,Fiber Optic Technology: instrumentation,Image Enhancement,Image Enhancement: instrumentation,Mice,Mice, Knockout,Microscopy, Fluorescence, Multiphoton,Microscopy, Fluorescence, Multiphoton: instrumentation,Molecular Imaging,Molecular Imaging: instrumentation},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs,HPL/SFE\_multispectral\_fluorescence},
    month = feb,
    number = {2},
    pages = {021103},
    pmid = {22463021},
    title = {{Targeted detection of murine colonic dysplasia in vivo with flexible multispectral scanning fiber endoscopy.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3380821\&tool=pmcentrez\&rendertype=abstract},
    volume = {17},
    year = {2012}
    }
  • [DOI] E. J. Seibel, J. a. Jo, D. C. Melville, R. S. Johnston, C. R. Naumann, and M. D. Saunders, “Image-guided intervention in the human bile duct using scanning fiber endoscope system,” in Optical fibers and sensors for medical diagnostics and treatment applications xii, 2012, p. 82180B.
    [Bibtex]
    @inproceedings{Seibel2012a,
    author = {Seibel, Eric J. and Jo, Javier a. and Melville, C. David and Johnston, Richard S. and Naumann, Christopher R. and Saunders, Michael D.},
    booktitle = {Optical FIbers and Sensors for Medical Diagnostics and Treatment Applications XII},
    doi = {10.1117/12.910070},
    keywords = {cholangioscope,flexible endoscope,fluorescence lifetime,image-guided biopsy,laser endoscopy,medical},
    mendeley-groups = {HPL/SFE\_small\_lumen\_imaging},
    month = feb,
    pages = {82180B},
    title = {{Image-guided intervention in the human bile duct using scanning fiber endoscope system}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.910070},
    volume = {8218},
    year = {2012}
    }
  • [DOI] L. Zhang, L. Y. Nelson, J. H. Berg, J. M. Eichenholz, and E. J. Seibel, “Optical Measure of Enamel Health: Ability to Triage High Risk Children in Communities without Dental Practitioners,” 2012 ieee global humanitarian technology conference, pp. 345-349, 2012.
    [Bibtex]
    @article{Zhang2012,
    author = {Zhang, Liang and Nelson, Leonard Y. and Berg, Joel H. and Eichenholz, Jason M. and Seibel, Eric J.},
    doi = {10.1109/GHTC.2012.52},
    isbn = {978-1-4673-3016-9},
    journal = {2012 IEEE Global Humanitarian Technology Conference},
    keywords = {- autofluorescence,alert practitioners to the,and portable means to,autofluorescence,autofluorescence ratio,caries,effective,global disease,laser-induced fluorescence,laser-induced fluorescence spectroscopy,of early childhood caries,risk,spectroscopy,will help manage this},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = oct,
    pages = {345--349},
    publisher = {Ieee},
    title = {{Optical Measure of Enamel Health: Ability to Triage High Risk Children in Communities without Dental Practitioners}},
    url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6387074},
    year = {2012}
    }
  • [DOI] L. Zhang, L. Y. Nelson, and E. J. Seibel, “Spectrally enhanced imaging of occlusal surfaces and artificial shallow enamel erosions with a scanning fiber endoscope.,” Journal of biomedical optics, vol. 17, iss. 7, p. 76019, 2012.
    [Bibtex]
    @article{Zhang2012a,
    abstract = {An ultrathin scanning fiber endoscope, originally developed for cancer diagnosis, was used to image dental occlusal surfaces as well as shallow artificially induced enamel erosions from human extracted teeth (n=40). Enhanced image resolution of occlusal surfaces was obtained using a short-wavelength 405-nm illumination laser. In addition, artificial erosions of varying depths were also imaged with 405-, 404-, 532-, and 635-nm illumination lasers. Laser-induced autofluorescence images of the teeth using 405-nm illumination were also obtained. Contrast between sound and eroded enamel was quantitatively computed for each imaging modality. For shallow erosions, the image contrast with respect to sound enamel was greatest for the 405-nm reflected image. It was also determined that the increased contrast was in large part due to volume scattering with a smaller component from surface scattering. Furthermore, images obtained with a shallow penetration depth illumination laser (405 nm) provided the greatest detail of surface enamel topography since the reflected light does not contain contributions from light reflected from greater depths within the enamel tissue. Multilayered Monte Carlo simulations were also performed to confirm the experimental results.},
    author = {Zhang, Liang and Nelson, Leonard Y and Seibel, Eric J},
    doi = {10.1117/1.JBO.17.7.076019},
    issn = {1560-2281},
    journal = {Journal of biomedical optics},
    keywords = {Dental Enamel,Dental Enamel: pathology,Diagnosis, Oral,Diagnosis, Oral: instrumentation,Endoscopes,Equipment Design,Equipment Failure Analysis,Fiber Optic Technology,Fiber Optic Technology: instrumentation,Humans,Image Enhancement,Image Enhancement: instrumentation,Luminescent Measurements,Luminescent Measurements: instrumentation,Microscopy, Confocal,Microscopy, Confocal: instrumentation,Reproducibility of Results,Sensitivity and Specificity,Tooth Erosion,Tooth Erosion: pathology},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = jul,
    number = {7},
    pages = {076019},
    pmid = {22894502},
    title = {{Spectrally enhanced imaging of occlusal surfaces and artificial shallow enamel erosions with a scanning fiber endoscope.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3602825\&tool=pmcentrez\&rendertype=abstract},
    volume = {17},
    year = {2012}
    }

2011

  • [DOI] M. A. B. Blank, M. Friedrich, J. D. Hamilton, P. Lee, J. Berg, and E. J. Seibel, “Laser Scanning Dental Probe for Endodontic Root Canal Treatment,” in Lasers in dentistry xvii, 2011, p. 788403–788403–7.
    [Bibtex]
    @inproceedings{Blank2011,
    author = {Blank, Molly A. B. and Friedrich, Michal and Hamilton, Jeffrey D. and Lee, Peggy and Berg, Joel and Seibel, Eric J.},
    booktitle = {Lasers in Dentistry XVII},
    doi = {10.1117/12.875274},
    editor = {Rechmann, Peter and Fried, Daniel},
    keywords = {cracks,endodontics,endoscope,imaging,laser scanning,root canal},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = feb,
    pages = {788403--788403--7},
    title = {{Laser Scanning Dental Probe for Endodontic Root Canal Treatment}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=732326},
    volume = {7884},
    year = {2011}
    }
  • [DOI] J. E. Chandler, D. C. Melville, C. M. Lee, M. D. Saunders, M. R. Burkhardt, and E. J. Seibel, “Improving Patient and User Safety during Endoscopic Investigation of the Pancreatic and Biliary Ducts,” in Design and quality for biomedical technologies iv, 2011, p. 789103–789103–11.
    [Bibtex]
    @inproceedings{Chandler2011,
    author = {Chandler, John E. and Melville, C. David and Lee, Cameron M. and Saunders, Michael D. and Burkhardt, Matthew R. and Seibel, Eric J.},
    booktitle = {Design and Quality for Biomedical Technologies IV},
    doi = {10.1117/12.873326},
    editor = {Raghavachari, Ramesh and Liang, Rongguang},
    keywords = {bending,endoscopic retrograde cholangiopancreatography,endoscopic safety,ercp,fluoroscopy,pancreatitis,scanning fiber endoscope,tip},
    mendeley-groups = {HPL,HPL/SFE\_small\_lumen\_imaging},
    month = feb,
    pages = {789103--789103--11},
    title = {{Improving Patient and User Safety during Endoscopic Investigation of the Pancreatic and Biliary Ducts}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=732886},
    volume = {7891},
    year = {2011}
    }
  • J. E. Chandler, C. M. Lee, A. P. Babchanik, D. C. Melville, M. D. Saunders, and E. J. Seibel, “Evaluation of a novel , ultrathin , tip-bending endoscope in a synthetic force-sensing pancreas with comparison to medical guide wires,” Medical devices: evidence and research, vol. 5, pp. 1-12, 2011.
    [Bibtex]
    @article{Chandler2011a,
    author = {Chandler, John E and Lee, Cameron M and Babchanik, Alexander P and Melville, C David and Saunders, Michael D and Seibel, Eric J},
    journal = {Medical Devices: Evidence and Research},
    keywords = {endoscopic retrograde cholangiopancreatography,ercp,minimally invasive therapy,pancreatic cancer,scanning fiber endoscope,sfe},
    mendeley-groups = {HPL,HPL/SFE\_small\_lumen\_imaging},
    pages = {1--12},
    title = {{Evaluation of a novel , ultrathin , tip-bending endoscope in a synthetic force-sensing pancreas with comparison to medical guide wires}},
    volume = {5},
    year = {2011}
    }
  • [DOI] M. J. Kundrat, P. G. Reinhall, and E. J. Seibel, “Method to Achieve High Frame Rates in a Scanning Fiber Endoscope,” Journal of medical devices, vol. 5, iss. 3, p. 34501, 2011.
    [Bibtex]
    @article{Kundrat2011a,
    author = {Kundrat, Matthew J. and Reinhall, Per G. and Seibel, Eric J.},
    doi = {10.1115/1.4004646},
    issn = {19326181},
    journal = {Journal of Medical Devices},
    mendeley-groups = {HPL,HPL/fiber-scan-dynamics-control},
    number = {3},
    pages = {034501},
    title = {{Method to Achieve High Frame Rates in a Scanning Fiber Endoscope}},
    url = {http://medicaldevices.asmedigitalcollection.asme.org/article.aspx?articleid=1451905},
    volume = {5},
    year = {2011}
    }
  • [DOI] M. J. Kundrat, P. G. Reinhall, C. M. Lee, and E. J. Seibel, “High Performance Open Loop Control of Scanning with a Small Cylindrical Cantilever Beam.,” Journal of sound and vibration, vol. 330, iss. 8, pp. 1762-1771, 2011.
    [Bibtex]
    @article{Kundrat2011,
    abstract = {The steady state response motion of a base excited cantilever beam with circular cross-section excited by a unidirectional displacement will fall along a straight line. However, achieving straight-line motion with a real cantilever beam of circular cross-section is difficult to accomplish. This is due to the fact that nonlinear effects, small deviations from circularity, asymmetric boundary conditions, and actuator cross coupling can induce whirling. The vast majority of previous work on cantilever beam whirling has focused on the effects of system nonlinearities. We show that whirling is a much broader problem in the design of resonant beam scanners in that the onset of whirling does not depend on large amplitude of motion. Rather, whirling is the norm in real systems due to small system asymmetries and actuator cross coupling. It is therefore necessary to control the growth of the whirling motion when a unidirectional beam motion is desired. We have developed a novel technique to identify the two eigen directions of the beam. Base excitation generated by virtual electrodes along these orthogonal eigen axes of the cantilever beam system generates tip vibration without whirl. This leads to accurate open loop control of the motion of the beam through the combined actuation of two pairs of orthogonally placed actuator electrodes.},
    author = {Kundrat, Matthew J and Reinhall, Per G and Lee, Cameron M and Seibel, Eric J},
    doi = {10.1016/j.jsv.2010.10.019},
    issn = {0022-460X},
    journal = {Journal of sound and vibration},
    mendeley-groups = {HPL,HPL/fiber-scan-dynamics-control},
    month = apr,
    number = {8},
    pages = {1762--1771},
    pmid = {21359102},
    publisher = {Elsevier},
    title = {{High Performance Open Loop Control of Scanning with a Small Cylindrical Cantilever Beam.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3045204\&tool=pmcentrez\&rendertype=abstract},
    volume = {330},
    year = {2011}
    }
  • [DOI] L. Zhang, L. Y. Nelson, and E. J. Seibel, “Red-shifted fluorescence of sound dental hard tissue.,” Journal of biomedical optics, vol. 16, iss. 7, p. 71411, 2011.
    [Bibtex]
    @article{Zhang2011,
    abstract = {Autofluorescence spectra were recorded in vitro from dentin, enamel, and whole teeth. The spectra exhibited a broad peak shifted by about 50 to 75 nm from the excitation wavelength and the shape of the spectra remained similar regardless of the excitation wavelength. The maximum of the autofluorescence spectra also exhibited a red-shift that depended upon the laser excitation wavelength. The amplitude of the red-shifted fluorescence spectra produced by 444 and 532 nm excitation lasers were compared to that produced by a 405 nm excitation laser. It was determined that the autofluorescence amplitude was not proportional to the inverse fourth power of the excitation laser wavelength. Therefore, the red-shifted fluorescence is not compatible with the previously proposed mechanism of Raman scattering. Instead, the mechanism giving rise to the laser-induced dental autofluorescence is explained by the red-edge-excitation effect.},
    author = {Zhang, Liang and Nelson, Leonard Y and Seibel, Eric J},
    doi = {10.1117/1.3606572},
    issn = {1560-2281},
    journal = {Journal of biomedical optics},
    keywords = {Dental Enamel,Dental Enamel: chemistry,Dentin,Dentin: chemistry,Fluorescence,Humans,Lasers,Lasers: diagnostic use,Scattering, Radiation,Spectrometry, Fluorescence,Spectrometry, Fluorescence: methods,Spectrometry, Fluorescence: statistics \& numerical data,Spectrum Analysis, Raman,Tooth,Tooth: chemistry},
    mendeley-groups = {HPL,HPL/SFE dental},
    month = jul,
    number = {7},
    pages = {071411},
    pmid = {21806257},
    title = {{Red-shifted fluorescence of sound dental hard tissue.}},
    url = {http://www.ncbi.nlm.nih.gov/pubmed/21806257},
    volume = {16},
    year = {2011}
    }
  • B. G. Saar, R. S. Johnston, C. W. Freudiger, S. X. Xie, and E. J. Seibel, “Coherent Raman scanning fiber endoscopy.,” Optics letters, vol. 36, iss. 13, pp. 2396-8, 2011.
    [Bibtex]
    @article{Saar2011,
    abstract = {Coherent Raman scattering methods allow for label-free imaging of tissue with chemical contrast and high spatial and temporal resolution. However, their imaging depth in scattering tissue is limited to less than 1 mm, requiring the development of endoscopes to obtain images deep inside the body. Here, we describe a coherent Raman endoscope that provides stimulated Raman scattering images at seven frames per second using a miniaturized fiber scanner, a custom-designed objective lens, and an optimized scheme for collection of scattered light from the tissue. We characterize the system and demonstrate chemical selectivity in mouse tissue images.},
    author = {Saar, Brian G and Johnston, Richard S and Freudiger, Christian W and Xie, X Sunney and Seibel, Eric J},
    issn = {1539-4794},
    journal = {Optics letters},
    keywords = {Animals,Endoscopy,Endoscopy: methods,Mice,Skin,Spectrum Analysis, Raman,Spectrum Analysis, Raman: methods},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs},
    month = jul,
    number = {13},
    pages = {2396--8},
    pmid = {21725423},
    title = {{Coherent Raman scanning fiber endoscopy.}},
    url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3164497\&tool=pmcentrez\&rendertype=abstract},
    volume = {36},
    year = {2011}
    }

2010

  • E. J. Seibel, “Side-stepping the valley of death in New York City,” Ieee potentials, pp. 14-18, 2010.
    [Bibtex]
    @article{Seibel2010,
    author = {Seibel, Eric J},
    journal = {IEEE Potentials},
    mendeley-groups = {HPL/TCE},
    pages = {14--18},
    title = {{Side-stepping the valley of death in New York City}},
    year = {2010}
    }
  • [DOI] T. D. Soper, D. R. Haynor, R. W. Glenny, and E. J. Seibel, “In vivo validation of a hybrid tracking system for navigation of an ultrathin bronchoscope within peripheral airways.,” Ieee transactions on bio-medical engineering, vol. 57, iss. 3, pp. 736-45, 2010.
    [Bibtex]
    @article{Soper2010,
    abstract = {Transbronchial biopsy of peripheral lung nodules is hindered by the inability to access lesions endoluminally due to the large diameter of conventional bronchoscopes. An ultrathin scanning fiber bronchoscope has recently been developed to advance image-guided biopsy several branching generations deeper into the peripheral airways. However, navigating a potentially complex 3-D path to the region of interest presents a challenge to the bronchoscopist. An accompanying guidance system has also been developed to track the bronchoscope through the airways, and display its position and intended path on a virtual display. Intraoperative localization of the bronchoscope was achieved by combining electromagnetic tracking (EMT) and image-based tracking (IBT). An error-state Kalman filter was used to model the disagreement between the two tracking sources. The positional tracking error was reduced from 14.22 and 14.92 mm by independent EMT and IBT, respectively, to 6.74 mm using the hybrid approach. Hybrid tracking of the scope orientation and respiratory motion compensation further improved tracking accuracy and stability, resulting in an average tracking error of 3.33 mm and 10.01 degrees.},
    author = {Soper, Timothy D and Haynor, David R and Glenny, Robb W and Seibel, Eric J},
    doi = {10.1109/TBME.2009.2034733},
    issn = {1558-2531},
    journal = {IEEE transactions on bio-medical engineering},
    keywords = {Animals,Biopsy,Biopsy: methods,Bronchi,Bronchi: anatomy \& histology,Bronchoscopes,Bronchoscopy,Bronchoscopy: methods,Humans,Image Processing, Computer-Assisted,Image Processing, Computer-Assisted: methods,Lung Neoplasms,Lung Neoplasms: pathology,Lung Neoplasms: surgery,Reproducibility of Results,Surgery, Computer-Assisted,Surgery, Computer-Assisted: methods,Swine},
    mendeley-groups = {HPL,HPL/Navigating\_SFE\_bronchoscope},
    month = mar,
    number = {3},
    pages = {736--45},
    pmid = {19846362},
    title = {{In vivo validation of a hybrid tracking system for navigation of an ultrathin bronchoscope within peripheral airways.}},
    url = {http://www.ncbi.nlm.nih.gov/pubmed/19846362},
    volume = {57},
    year = {2010}
    }

2009

  • [DOI] E. J. Seibel, D. C. Melville, J. K. C. Lung, A. P. Babchanik, C. M. Lee, R. S. Johnston, and J. a. Dominitz, “Swallowable Capsule with Air Channel for Improved Image-Guided Cancer Detection in the Esophagus,” in Medical imaging 2009: visualization, image-guided procedures, and modeling, 2009, p. 72611C–72611C–7.
    [Bibtex]
    @inproceedings{Seibel2009a,
    author = {Seibel, Eric J. and Melville, C. David and Lung, Jonathan K. C. and Babchanik, Alexander P. and Lee, Cameron M. and Johnston, Richard S. and Dominitz, Jason a.},
    booktitle = {Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling},
    doi = {10.1117/12.812320},
    editor = {Miga, Michael I. and Wong, Kenneth H.},
    keywords = {7261,72611c,and modeling,barrett,cancer screening,edited by michael i,endoscopic procedures,esophageal sphincter,gastroesophageal junction,image-guided procedures,kenneth h,lower,medical imaging 2009,miga,of spie vol,proc,s esophagus,tethered-capsule endoscope,unsedated intervention,visualization,wong},
    mendeley-groups = {HPL/TCE},
    month = feb,
    pages = {72611C--72611C--7},
    title = {{Swallowable Capsule with Air Channel for Improved Image-Guided Cancer Detection in the Esophagus}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1335722},
    volume = {7261},
    year = {2009}
    }
  • [DOI] T. D. Soper, D. R. Haynor, R. W. Glenny, and E. J. Seibel, “Validation of CT-Video Registration for Guiding a Novel Ultrathin Bronchoscope to Peripheral Lung Nodules Using Electromagnetic Tracking,” in Medical imaging 2009: visualization, image-guided procedures, and modeling, 2009, p. 72610C–72610C–13.
    [Bibtex]
    @inproceedings{Soper2009,
    author = {Soper, Timothy D. and Haynor, David R. and Glenny, Robb W. and Seibel, Eric J.},
    booktitle = {Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling},
    doi = {10.1117/12.812329},
    editor = {Miga, Michael I. and Wong, Kenneth H.},
    mendeley-groups = {HPL,HPL/Navigating\_SFE\_bronchoscope},
    month = feb,
    pages = {72610C--72610C--13},
    title = {{Validation of CT-Video Registration for Guiding a Novel Ultrathin Bronchoscope to Peripheral Lung Nodules Using Electromagnetic Tracking}},
    url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=815263},
    volume = {7261},
    year = {2009}
    }

2008

  • E. J. Seibel, R. E. Carroll, J. A. Dominitz, R. S. Johnston, D. C. Melville, C. M. Lee, S. M. Seitz, S. Member, and M. B. Kimmey, “Tethered Capsule Endoscopy , A Low-Cost and High-Performance Alternative Technology for the Screening of Esophageal Cancer and Barrett ’ s Esophagus,” Ieee transactions on bio-medical engineering, vol. 55, iss. 3, pp. 1032-1042, 2008.
    [Bibtex]
    @article{Seibel2008a,
    author = {Seibel, Eric J and Carroll, Robert E and Dominitz, Jason A and Johnston, Richard S and Melville, C David and Lee, Cameron M and Seitz, Steven M and Member, Senior and Kimmey, Michael B},
    journal = {IEEE transactions on bio-medical engineering},
    mendeley-groups = {HPL/TCE},
    number = {3},
    pages = {1032--1042},
    title = {{Tethered Capsule Endoscopy , A Low-Cost and High-Performance Alternative Technology for the Screening of Esophageal Cancer and Barrett ’ s Esophagus}},
    volume = {55},
    year = {2008}
    }
  • C. J. Engelbrecht, R. S. Johnston, E. J. Seibel, and F. Helmchen, “Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo,” Optics express, vol. 16, iss. 8, pp. 5556-5564, 2008.
    [Bibtex]
    @article{Engelbrecht2008,
    author = {Engelbrecht, Christoph J and Johnston, Richard S and Seibel, Eric J and Helmchen, Fritjof},
    journal = {OPTICS Express},
    mendeley-groups = {HPL,HPL/SFE\_microscope-advanced designs},
    number = {8},
    pages = {5556--5564},
    title = {{Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo}},
    volume = {16},
    year = {2008}
    }

2007

  • [DOI] R. E. Carroll and S. M. Seitz, “Rectified Surface Mosaics,” in 2007 ieee 11th international conference on computer vision, 2007, pp. 1-8.
    [Bibtex]
    @inproceedings{Carroll2007,
    author = {Carroll, Robert E. and Seitz, Steven M.},
    booktitle = {2007 IEEE 11th International Conference on Computer Vision},
    doi = {10.1109/ICCV.2007.4409128},
    isbn = {978-1-4244-1630-1},
    mendeley-groups = {HPL/TCE},
    pages = {1--8},
    publisher = {Ieee},
    title = {{Rectified Surface Mosaics}},
    url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=4409128},
    year = {2007}
    }