Advanced Physical Diagnosis
Examination
  • Techniques
• 1st & 2nd Heart Sounds
• 2nd & 3rd Heart Sounds
• Clicks and Snaps
• Murmurs
• Rubs
  • Demonstrations
Historical
Pathophysiology
Associated Evaluations
  • Patient HX
  • Physical Exam
  • Laboratory & Imaging
Differential Dx
Evidence Base
• Accuracy in Diagnosis of Systolic Murmurs
• Accuracy in Diagnosis of Diastolic Murmurs
• Accuracy in Diagnosis of CHF
References
Teaching Tips
[Skill Modules >> Heart Sounds & Murmurs >> Differential Dx ]

Differential Diagnosis: Heart Sounds & Murmurs

Differential Diagnosis of Clinical Symptoms

Dyspnea
  • Heart Failure
  • Ischemic heart disease (anginal equivalent)
  • Pulmonary Embolism
  • Lung Disease including COPD & Asthma
  • Severe Anemia
New York Heart Association Classification for Heart Failure
Class I Dyspnea only with vigorous exertion
Class II

Dyspnea with moderate exertion

Class III Dyspnea with mild exertion, may have mild dyspnea at rest
Class IV Significant dyspnea at rest
Chest pain at rest
  • Myocardial infarction
  • Unstable angina
  • Dissecting aortic aneurysm
  • Esophagitis
  • Pulmonary Embolism
  • Pneumothorax
  • Pericarditis
  • Pleuritic pain
  • Musculoskeletal pain including costochondritis
  • Herpes zoster
Chest pain on exertion
  • Angina related to atherosclerosis
  • Coronary vasospasm with normal coronary arteries
  • Aortic stenosis
  • Hypertrophic cardiomyopathy
  • Musculoskeletal

back to top

Differential Diagnosis of Systolic Murmurs

Systolic Ejection
  • Benign
    • Innocent systolic murmur (vibratory)
    • Flow murmurs
      • Hemodynamic effect (i.e., fever, hyperthyroidism, severe anemia)
      • Athlete's heart
    • Atrial septal defect (incidental)
  • Pathologic
    • Aortic stenosis
    • Pulmonary stenosis
    • Hypertrophic cardiomyopathy
    • Atrial septal defect
  • Pansystolic
    • Tricuspid reflux
    • Mitral reflux
    • Ventricular septal

back to top

Differential Diagnosis of Pericardial Friction Rub

Caused by inflammation of the pericardial sac with or without fluid.

Pericarditis
  • Infectious
    • viral,
    • bacterial
    • tuberculous
    • fungal
  • Noninfectious
    • myocardial infarction
    • uremia
    • malignancy
    • myxedema
    • trauma
    • open-heart surgery
  • Autoimmune
    • rheumatic fever
    • drug induced (pracainamide)
    • post-myocardial infarction (Dressler's syndrome)
    • collagen vascular disease

back to top