| Pleural versus Pericardial Friction Rub: | 
					
						| Pleural | Pericardial | 
					
						| Auscultatory sounds: | 
					
						| One sound on inspiration and one sound on expiration(expiratory sound may be absent)
 | One systolic sound and two diastolic sounds (systolic sound between S1 and S2)
 (one diastolic sound in early diastole and one at end diastole)
 (sounds are independent of respiration)
 | 
					
						|  (pleural) |  (pericardial) | 
					
						| Site: | 
					
						| Over lower anterolateral chest (left or right) | Over pericardium, often loudest at LLSB | 
					
						| Sound superficial; close to chest wall | Sound farther from chest wall | 
					
						| Rub often transient | Rub often transient Note: many patients with a pericardial friction rub also have a tachycardia | 
					
						| Respiratory variation: | 
					
						| Sounds disappear if hold breath | Tends to be louder during inspiration, also can sometimes better detect during forced expiration with the patient leaning forward | 
					
						| Sound characteristics (similar for both): | 
					
						| High frequency (hear best with diaphragm of stethoscope)
 | High frequency (hear best with diaphragm of stethoscope)
 | 
					
						| Grating or creaking sound | Scratchy, gratin or squeaking |