Result for
Tag: pregnancy
February 11, 2021
Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19
SARS-CoV-2 RNA was not detected by RT-qPCR in breast milk samples (n=37) collected from 18 women following COVID-19 diagnosis. Breast milk was collected on average 12.0 +/- 8.9 days after onset of signs and/or symptoms. In contrast, 76% and 80% of samples contained anti-SARS-CoV-2 IgA and IgG, respectively, and 62% of samples neutralized SARS-CoV-2 in…
February 10, 2021
Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)
An observational cohort study among pregnant patients (n=1,219 patients, 47% asymptomatic, 27% mild illness, 14% moderate, 8% severe, and 4% critical) who tested positive for SARS-CoV-2 found that pregnant patients with severe-critical COVID-19 were at higher risk of perinatal complications compared to those with mild or asymptomatic infection, including 6% incidence of venous thromboembolism among…
February 9, 2021
Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study
The overall rate of pregnancy complications was similar between SARS-CoV-2 infected and non-infected women in a population-based study in Spain (n=2,225). Pregnancy complications (miscarriage, preeclampsia, preterm delivery, perinatal death, small-for-gestational age, or neonatal admission) occurred in 43 (14%) of 317 SARS-CoV-2-infected women compared to 268 (14%) of 1,908 non-infected women. However, higher rates of preterm…
February 1, 2021
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios
IgG antibodies to SARS-CoV-2 from pregnant women with symptomatic or asymptomatic SARS-CoV-2 infection were transferred across the placenta, and cord antibody concentrations were positively correlated with maternal IgG concentrations (r=0.9). IgG antibodies were detected in cord blood from 72 of 83 newborns (87%), while IgM antibodies were not detected in any cord blood samples. Eleven…
January 28, 2021
Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State
Among a cohort of 240 pregnant patients with SARS-CoV-2 infection in Washington State, the COVID-19 hospitalization and case fatality rates were 3.5-fold and 13.6-fold higher, respectively, compared to rates among similarly-aged females and males with SARS-CoV-2 infections in Washington State. One in 11 developed severe or critical disease, 1 in 10 were hospitalized for COVID-19….
January 27, 2021
SARS-CoV-2 Serology Levels in Pregnant Women and Their Neonates
A study of the serologic response to SARS-CoV-2 infection in pregnant women (n = 88) found that asymptomatic pregnant women mounted a lower immune response than symptomatic pregnant women, and that maternal IgG antibodies were positively correlated with levels in neonates. Maternal IgM and IgG levels peaked around 15 and 30 days after onset of…
SARS-CoV-2 Infection in Pregnancy Is Associated with Robust Inflammatory Response at the Maternal-Fetal Interface
[Pre-print, not per-reviewed] A study of SARS-CoV-2 in pregnant women showed that in pregnant women with COVID-19, ACE2 is widely expressed in the placenta at term compared to low levels of expression in noninfected mothers. Despite the in vitro susceptibility of cytotrophoblasts (a type of placental cell) to SARS-CoV-2 infection, viral RNA was detected in…
January 26, 2021
Pregnancy as a Risk Factor for Severe Coronavirus 2019 (COVID-19) Disease Using Standardized Clinical Criteria
A retrospective cohort study in the US (n=262 women with symptomatic COVID-19) found that compared to non-pregnant women, pregnant women were at significantly increased risk of developing severe COVID-19. After adjusting for ethnicity and insurance status, pregnant patients were between 3.6 and 5.7 times as likely to have severe disease, depending on the criteria used…
January 12, 2021
Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study
A nationwide cohort study in Sweden found that births occurring between April to May 2020 were not at elevated risk of preterm birth and stillbirth compared to births occurring during the same period in 2019. Excluding mothers with COVID-19 produced similar results. Among mothers in the cohort, the mean number of maternal healthcare visits (2.3)…
Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study
No association was observed between Influenza and Tdap vaccination status and clinical presentation of SARS-CoV-2 and/or severity of symptoms in a cohort of SARS-CoV-2 positive pregnant women in Spain (n=1,150). However, low vaccination adherence was observed among the subgroup of women who reported Latin-American ethnicity, which could have implications for the SARS-CoV-2 vaccination campaign. de…
Previous page Next page