PHCOL 537: Cell Membranes
Molecular Neurobiology of the Cell Membrane
Meets in K550 Health Sciences Center, Wednesdays 3:00 - 5:00 PM, Winter 2011
Neil Nathanson, Ph.D.
K536A Health Sciences Center, 543-9457
This graduate level course covers the cell biology of eukaryotic cell membranes and how they contribute to normal functioning and disease.
Students will take turns introducing weekly topics and will participate in discussions of 2-3 papers assigned for each class.
Grades will be based on presentations and class participation.
Tentative list of topics:
Week 1 Introduction to cell membranes and lipids (Neil Nathanson)
Week 2 Introduction to membrane proteins (Neil Nathanson)
Week 3 Membrane lipids as scaffolds
Lipid modifications of proteins
Week 4 Cell adhesion molecules
Molecules that attract or repel neuronal growth cones
Week 5 Epithelial cell polarity and protein sorting
Differential sorting of proteins in neurons
Week 6 Myelination
Retrograde signaling from the nerve terminal to the nucleus
Week 7 Endocytosis and intracellular trafficking of membrane receptors (1 or 2 people)
Clathrin dependent endocytosis- the EGF receptor
Clathrin-independent endocytosis mechanism
Week 8 Signaling domains in membranes
Week 9 Trafficking/Processing of APP/SREBP/intramembrane proteolysis
Week 10 ER stress response