Result for
Topic: Vaccines and Immunity
January 12, 2021
Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study
No association was observed between Influenza and Tdap vaccination status and clinical presentation of SARS-CoV-2 and/or severity of symptoms in a cohort of SARS-CoV-2 positive pregnant women in Spain (n=1,150). However, low vaccination adherence was observed among the subgroup of women who reported Latin-American ethnicity, which could have implications for the SARS-CoV-2 vaccination campaign. de…
January 8, 2021
Neutralization of N501Y Mutant SARS-CoV-2 by BNT162b2 Vaccine-Elicited Sera
[pre-print, not peer-reviewed] Sera from people vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2) (n=20) had equivalent neutralizing antibody titers to the SARS-CoV-2 strain on which the vaccine was based and a laboratory-developed SARS-CoV-2 strain carrying a N501Y substitution, which is one of the mutations associated with rapidly spreading variants in the United Kingdom and South…
January 7, 2021
A Longitudinal Study of SARS-CoV-2-Infected Patients Reveals a High Correlation between Neutralizing Antibodies and COVID-19 Severity
Serum samples from a cohort of 140 SARS-CoV-2 positive patients suggest that increasing symptom severity is correlated with higher neutralizing antibody (nAb) titers. Only 1 of 44 patients admitted to the ICU did not develop a nAb response by the time of sampling, while nAb response was more heterogenous and less frequently observed among hospitalized…
Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection
IgG antibodies against the Spike protein and the receptor binding domain (RBD) were relatively stable over 6 months in a cohort study of individuals with confirmed COVID-19 (n=188). Among 40 individuals with blood samples 6-8 months post-symptom onset, 90%, 88%, and 90% remained seropositive for anti-spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Paired timepoint…
January 6, 2021
The Duration, Dynamics and Determinants of SARS-CoV-2 Antibody Responses in Individual Healthcare Workers
A longitudinal SARS-CoV-2 seroprevalence study of healthcare workers in the United Kingdom found peak IgG antibody levels to SARS-CoV-2 nucleocapsid was 24 days following the first positive PCR test with a mean antibody half-life of 85 days. Antibodies waned faster in younger adults and those without symptoms. Anti-spike IgG levels remained stably detected after a…
Optimizing Vaccine Allocation for COVID-19 Vaccines Critical Role of Single-Dose Vaccination
[Pre-print, not-peer reviewed] Utilizing an age-stratified mathematical model, a study of vaccine allocation strategy suggested that maintaining current social distancing interventions and speedy vaccine deployment were important, and the optimal allocation of vaccine depends on the single-dose efficacy (SDE). If SDE is high, single-dose vaccination would be the optimal use of vaccine under most scenarios…
A Method for Prioritizing Risk Groups for Early SARS-CoV-2 Vaccination, By the Numbers
[Pre-print, not-peer reviewed] A logistic regression model to predict COVID-19 case and death risk by age, race, and sex found that if the 17 demographic groups at highest risk of death from COVID-19 were prioritized for vaccination, it would require only 3.7% of the vaccine supply needed to vaccinate all the United States, and yet…
January 5, 2021
Confidence and Receptivity for COVID-19 Vaccines: A Rapid Systematic Review
A systematic review and meta-analysis showed declining COVID-19 vaccine acceptance, from >70% in March to <50% in October. In an analysis of data from 126 studies and surveys, drivers of decline in vaccine acceptance included perceived risk, concerns over vaccine safety and effectiveness, doctors’ recommendations, and inoculation history. In assessing the impact of survey design,…
Comprehensive Mapping of Mutations to the SARS-CoV-2 Receptor-Binding Domain That Affect Recognition by Polyclonal Human Serum Antibodies
[Pre-print, not peer reviewed] Mutations in three main epitopes of the SARS-CoV-2 spike receptor-binding domain (RBD) affect neutralizing activity of convalescent polyclonal serum. Mutations that affect neutralizing activity usually occur at only a few sites and mutations occurring at the E484 site had the largest average effect with a >10 fold reduction in the neutralization…
January 4, 2021
Timing of COVID-19 Vaccine Approval and Endorsement by Public Figures
A study using two randomized experiments embedded in surveys found that perceptions of political influence on the COVID-19 vaccine approval process in the US could impact the confidence in, and uptake of vaccines. Announcing approval of a COVID-19 vaccine one week before the presidential election, compared to one week after, reduced reported intentions to vaccinate…
Previous page Next page