Cystic Fibrosis Research and Translation Center

The primary goal of the Cystic Fibrosis Research and Translation Center (CFRTC) is to be a world leader in clinical-translational science in cystic fibrosis (CF), spanning from early drug development to dissemination into the CF community. Through the strength of the Microbiology, Genomics, Host Response and Clinical Cores as well as the pilot program, we strive to understand the bacterial-host interactions in the pulmonary and gastrointestinal tracts of patients with CF. We focus on interdisciplinary studies and encourage new investigators in digestive diseases, nutrition and metabolism, and inflammation.  To help reach this important goal, we plan to implement the following four aims:

  1. Provide resources and expertise to expedite development of promising new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences including maldigestion and malnutrition, hepatobiliary disease and chronic lung disease.
  2. Foster collaboration across P30 biomedical cores and enhance translational research nationally through sharing of human and bacterial repositories linked to clinical databases. Utilize the shared specimen and data resources to develop improved assays, new drug screening assays, biomarkers and improved clinical outcome measures.
  3. Enhance understanding of evolving bacterial ecosystems and resultant host response in CF gastrointestinal and respiratory tracts, and how these interactions impact health.
  4. Better understand the metabolic and inflammatory consequences of CFTR dysfunction, including probing whether CFTR modulators impact CFTR dysfunction, thereby leading to pro-inflammatory changes in immune cells in patients with CF.

Supported by a grant from the National Institutes of Health (NIDDK P30 DK 089507). Please reference this grant number on all publications resulting from support provided by this Core Center grant.