EMPHASIS AREAS OF THE RESEARCH BASE

The CFRTC and CF RDP membership has a research base which totals over $20 million in direct costs annually for active ongoing individual research grants as well as $5 million in programmatic infrastructure grants. We have identified ten areas of research emphasis as outlined below. Emphasis areas are defined as a common research interest consisting of at least 3 collaborating and independently funded investigators who are benefitting from one or more biomedical core services and/or receiving pilot funding.

• Translational research
• Clinical outcome measures, biomarkers and study design
• Effect of P. aeruginosa acquisition on host-pathogen interactions and adaptations
• Growth and nutrition in infants with CF
• International academic study coordination
• Microbial interactions
• Antibiotic resistance and virulence factors
• Bacterial communities in GI and respiratory tracts
• Macrophage function and host response to lung infection
• Metabolic consequences of CFTR dysfunction