Cystic Fibrosis Research and Translation Center (CFRTC)
The primary goal of the Cystic Fibrosis Research and Translation Center (CFRTC) is to serve as a national resource to enhance the translation of promising laboratory findings into novel therapies for individuals with cystic fibrosis, with special focus on antimicrobial and anti-inflammatory treatments. To help reach this important goal, we plan to implement the following four aims:
- Provide resources and expertise to expedite development of promising new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences including maldigestion and malnutrition, chepatobiliary disease and chronic lung disease.
- Foster collaboration across P30 biomedical cores to enhance translational research through sharing of existing and development of expanded human and bacterial repositories linked to clinical databases. Utilize these shared specimen and data resources to develop improved assays and clinical outcome measures.
- Enhance understanding of bacterial pathogenesis in CF lung disease focusing on development of better antimicrobial approaches to eradicate initial infections and prevent establishment of chronic infection.
- Enhance understanding of host inflammatory response of CF preceding and at the time of bacterial infection to develop better diagnostic and prognostic markers as well as novel antiinflammatory therapeutic approaches.
Supported by a grant from the National Institutes of Health (NIDDK P30 DK 089507). Please reference this grant number on all publications resulting from support provided by this Core Center grant.