Dr. Keene’s clinical specialty is neuropathology and ophthalmic pathology with special emphasis on degenerative diseases of brain and retina. Dr. Keene is the Leader of the UW ADRC neuropathology core and is actively involved in the acquisition, storage, and analysis of brain tissues from patients with various neurodegenerative diseases and healthy controls in ADRC and Pacific Northwest Udall Center of Excellence for Parkinson's Disease Research (PANUC) studies.
In research, Dr. Keene focuses on developing a better understanding of the key genes and molecular pathways involved in age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, vascular brain injury, frontotemporal lobar degeneration, and chronic traumatic brain injury. He is pursuing experimental models of neurodegeneration, such as human-derived stem cells, with the ultimate goal of identify novel therapeutic targets and developing better ways to treat or prevent these disorders. In addition to clinical and research activities, Dr. Keene directs the graduate level “Mechanisms of Neurodegeneration” course as well as the pathology component of the Basic and Clinical Science Course for ophthalmology residents and fellows, and is actively involved in teaching residents and fellows in pathology, ophthalmology, neurology, and neurosurgery.
Dr. Keene leads the ADRC's monthly Clinicopathologic Correlation Conference (CPC)
Neuropathology; Genetic risk factors of neurodegeneration