AD@UW is a monthly 90-minute lunch-time meeting held 12:00 pm - 1:30 pm on 4th Fridays that is intended to provide a basic understanding of Alzheimer's disease and related dementias as well as research resources available through the UW ADRC.
Each month, AD@UW will be focused on a different ADRD topic, and will include training, Q&A, and discussion led by UW ADRC faculty guides. Content will feature selected videos from the online Dementia for Scientists Curriculum published by the Michigan Alzheimer's Disease Center. UW Faculty guides will also outline and discuss resources available at the UW ADRC, including biological samples, imaging and clinical data, and faculty expertise.
All meetings this year will be held remotely via Zoom. Please see below for meeting links and talk recordings.
AD@UW Schedule
Schedule posts include any recommended preparation prior to the in-person session.
Past UW@AD Presentations
(Recordings & Curriculum Resources)
AD Diagnosis: The Changing Landscape
Panel Discussion
3/28/25, 12:00-1:30
The NIA-AA Research Framework for Alzheimer’s disease seems to functionally re-define AD from a clinical disorder with cognitive impairment front-and-center to a biological definition of simply having the presence of Abeta, and then tau pathology. Cognitive decline is the presumed eventual consequence of this pathology, but it is not so central in the framework. This changes how people with AD are identified, potentially how drugs are developed and deployed, and possibly how AD-facing policy evolves. In the session, we would a) talk through the framework itself, understanding what it is changing; b) discuss the general pros and cons of a change like this; c) discuss how this shift might impact research (basic, translational, and clinical) into Alzheimer’s disease now and in the future.
Reading Assignments:
https://www.sciencedirect.com/science/article/pii/S1552526018300724?via%3Dihub
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13859
Dementia Definition & Evaluation and features an overview of UW ADRC Clinical Core.
2/28/25, 12:00-1:30
Faculty Guide: Sumie Jayadev & Robin Lawrence
At this session, there will also be Q/A on the content of the videos below (also on the AD@UW website). The first three videos in blue are required viewing for current REC trainees, while the three additional videos may be of interest to those looking to dive a bit deeper. Please be sure to have watched these videos before the session and come with 2-3 questions for discussion.
Dementia for Scientists Curriculum
Defining Dementias, Clinical Features, Natural History (Video)
Definition, clinical features and history of primary degenerative diseases. Required for REC trainees.
Neuropsychology of Alzheimer's Disease and Mild Cognitive Impairment (Video)
Clinical presentation, underlying neuropathology, and cognitive ramifications of AD and MCI. Required for REC trainees.
Clinical Evaluation of Dementias Part 1 (Video)
Discusses a general approach to evaluation of patients presenting with cognitive change. Required for REC trainees.
Clinical Evaluation of Dementias Part 2 (Video)
Case presentations of primary and secondary dementias.
Behavioral & Psychiatric Features of Dementia Part 1 (Video)
Background on general geriatric psychiatry including anxiety disorders, depression, psychosis, etc.
Behavioral & Psychiatric Features of Dementia Part 2 (Video)
Book Discussion
1/24/25, 12:00-1:30
The Mismeasure of Man by Stephen Jay Gould
Faculty Guide: Paul Crane
If you are a current REC Trainee, please read (or listen to) it before the session and come prepared to discuss.
Dementia Pathology and Pathogenesis
Friday - 10/25/24 - 12:00-1:30
Faculty guides
Caitlin Latimer, MD, PhD
Dee Jansson
Dementia for Scientists Curriculum
Alzheimer's Disease - The amyloid cascade, alternative mechanisms (Video)
Introduction to the role of amyloid β in neurodegenerative diseases. Required for REC trainees.
Alzheimer's Disease - Amyloidopathy (Video)
Fundamental concepts of amyloidopathy. Required for REC trainees.
Alzheimer's Disease - Tau Biology and Pathology (Video)
In-depth discussion for scientists with genetics background who want to know more about formation and structure of tau.
Lewy Body Dementia - Synucleinopathies & Synuclein (Video)
In-depth discussion of LBD and alpha-synulcein.
Pathology of Dementia, Degenerative and Spinal Cord Diseases (Video)
Warning: graphic content. Neuropathology of different types of dementia and movement disorders.
February 23: Book Discussion: Never Split the Difference by Chris Voss
Faculty Guides:
Jeff Iliff, PhD
January 26: Dementia Definition and Evaluation
Faculty Guides: Suman Jayadev, MD, Andrea Stocco, PhD
Recordings:
UW ADRC Clinical Core with Suman Jayadev, MD
Automated Assessment and Monitoring of Memory Function with Predictive Computational Models with Andrea Stocco, PhD
Dementia for Scientists Curriculum
Defining Dementias, Clinical Features, Natural History (Video)
Definition, clinical features and history of primary degenerative diseases. Required for REC trainees.
Neuropsychology of Alzheimer's Disease and Mild Cognitive Impairment (Video)
Clinical presentation, underlying neuropathology, and cognitive ramifications of AD and MCI. Required for REC trainees.
Clinical Evaluation of Dementias Part 1 (Video)
Discusses a general approach to evaluation of patients presenting with cognitive change. Required for REC trainees.
Clinical Evaluation of Dementias Part 2 (Video)
Case presentations of primary and secondary dementias.
Behavioral & Psychiatric Features of Dementia Part 1 (Video)
Background on general geriatric psychiatry including anxiety disorders, depression, psychosis, etc.
Behavioral & Psychiatric Features of Dementia Part 2 (Video)
December 8: Catherine the Great and Alois Alzheimer: An Unexpected Connection
Faculty gudie: Thomas Bird, MD
May 24, 2024: Therapeutics in AD
Faculty Guides:
Michael Rosenbloom, MD
Elaine Peskind, MD
Dementia Pathology and Pathogenesis
Friday - 10/27/23 - 12:00-1:30
Faculty guides
Caitlin Latimer, MD, PhD
Kim Alonge, PhD
Dementia for Scientists Curriculum
Alzheimer's Disease - The amyloid cascade, alternative mechanisms (Video)
Introduction to the role of amyloid β in neurodegenerative diseases. Required for REC trainees.
Alzheimer's Disease - Amyloidopathy (Video)
Fundamental concepts of amyloidopathy. Required for REC trainees.
Alzheimer's Disease - Tau Biology and Pathology (Video)
In-depth discussion for scientists with genetics background who want to know more about formation and structure of tau.
Lewy Body Dementia - Synucleinopathies & Synuclein (Video)
In-depth discussion of LBD and alpha-synulcein.
Pathology of Dementia, Degenerative and Spinal Cord Diseases (Video)
Warning: graphic content. Neuropathology of different types of dementia and movement disorders.
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Fri. June 23, 2023, 12:00 - 1:30 pm AD Imaging |
Faculty Guides: Swati Rane Levendovszky Tom Grabowski |
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Fri. May 26, 2023, 12:00 - 1:30 pm DoD Grant Funding |
Faculty Guides: Jeff Iliff Brian Kraemer
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December 2022
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Dementia Definition and Evaluation Friday - 12/2/22 - 12:00-1:30 |
Faculty Guides: |
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Dementia for Scientists Curriculum Defining Dementias, Clinical Features, Natural History (Video) Neuropsychology of Alzheimer's Disease and Mild Cognitive Impairment (Video) Clinical Evaluation of Dementias Part 1 (Video) Clinical Evaluation of Dementias Part 2 (Video) Behavioral & Psychiatric Features of Dementia Part 1 (Video) Behavioral & Psychiatric Features of Dementia Part 2 (Video) |
October 2022
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Dementia Pathology and Pathogenesis Friday - 10/28/22 - 12:00-1:30 |
Faculty guides |
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Dementia for Scientists Curriculum
Alzheimer's Disease - The amyloid cascade, alternative mechanisms (Video) Alzheimer's Disease - Amyloidopathy (Video) Alzheimer's Disease - Tau Biology and Pathology (Video) Lewy Body Dementia - Synucleinopathies & Synuclein (Video) Vascular Dementias (Video) Pathology of Dementia, Degenerative and Spinal Cord Diseases (Video) |
April 2022
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ADRC Native Research and Resource Core Friday - April 22, 2022 - 12:00-1:30 pm
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Faculty guides
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May 2022
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Dementia Imaging Friday - May 27, 2022 - 12:00-1:30 pm |
Faculty Guides:
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Dementia for Scientists Curriculum PET Imaging of Dementias (Video) Using brain imaging and biomarkers for diagnosis and investigation of Alzheimer's Disease (Video) |
June 2022
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ACT - Adult Changes in Thought Study Friday - June 24, 2022 - 12:00-1:30 pm
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Faculty guides
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February 2022
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The NIH Research Project Grant (R01) Friday - Feb. 25, 2022 - 12:00-1:30 pm
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Faculty guides Marie Davis, MD, PhD |
January 2022
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Book discussion: How Not to Study a Disease: the Story of Alzheimer’s by Dr. Karl Kerrup, PhD. Moderated by Jeff Iliff, PhD, Professor, UW Dept. Psychiatry & Behavioral Sciences/UW Neurology/UW ADRC REC Lead Monday - 1/10/22 - 1:00-2:00 pm Meeting ID 973 9881 4318 |
Faculty Guides: Jeff Iliff, PhD
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Book discussion: How Not to Study a Disease: the Story of Alzheimer’s Karl Herrup, PhD, Professor of Neurobiology, University of Pittsburgh School of Medicine Investigator, University of Pittsburgh ADRC This discussion directly follows the January ADRC Seminar Series: Location, location, location: DNA in microglial cytoplasm spells trouble to be held at 12 - 1 pm at the same Zoom link as listed above. |
October 2021
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Dementia Pathology and Pathogenesis Friday - 10/25/21 - 12:00-1:30 |
Faculty guides |
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Dementia for Scientists Curriculum
Alzheimer's Disease - The amyloid cascade, alternative mechanisms (Video) Alzheimer's Disease - Amyloidopathy (Video) Alzheimer's Disease - Tau Biology and Pathology (Video) Lewy Body Dementia - Synucleinopathies & Synuclein (Video) Vascular Dementias (Video) Pathology of Dementia, Degenerative and Spinal Cord Diseases (Video) |
September 2021
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Dementia Definition and Evaluation Friday - 9/24/21 - 12:00-1:30 |
Faculty Guides: |
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Dementia for Scientists Curriculum Defining Dementias, Clinical Features, Natural History (Video) Neuropsychology of Alzheimer's Disease and Mild Cognitive Impairment (Video) Clinical Evaluation of Dementias Part 1 (Video) Clinical Evaluation of Dementias Part 2 (Video) Behavioral & Psychiatric Features of Dementia Part 1 (Video) Behavioral & Psychiatric Features of Dementia Part 2 (Video) |
June 2021
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Research in Ethnically Diverse Populations: Outreach, Recruitment, and Engagement (ORE) Core Friday - 6/25/21 - 12:00-1:30 pm
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Faculty Guides: Ka'imi Sinclair, PhD, MPH |
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Dementia for Scientists Curriculum Engaging African Americans in Research: Value of a Participant Registry (Video) (required for REC trainees) Improving Accuracy in the Use of Cognitive Testing with African Americans (Video) Cognitive and Brain Aging in Older African Americans (Video) |
May 2021
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ADRC DB & Biostatistical Resources Career Development Awards Friday - 5/28/21 - 12:00-1:30 pm
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Faculty Guides: Ellen Wijsman, PhD Nicole Liachko, PhD Abigail Schindler, PhD |
April 2021
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Imaging Friday - 4/23/21 - 12:00-1:30 pm Meeting ID: 921 9312 6191 |
Faculty Guides: |
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Dementia for Scientists Curriculum PET Imaging of Dementias (Video) Using brain imaging and biomarkers for diagnosis and investigation of Alzheimer's Disease (Video) |
March 2021
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ACT and Psychometrics Friday - 3/26/21 - 12:00-1:30 pm
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Faculty Guides: |
January 2021
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Therapy Development in Dementias Recording Part 1 - Preclinical Considerations for Alzheimer's Disease. Recording Part 2 - Alzheimer's Disease Therapeutics: State of the Art
Friday - 1/22/21 - 12:00-1:30 pm |
Faculty Guides:
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Dementia for Scientists Curriculum Alzheimer's Disease: Current & Future Drug Treatments (Video) Clinical Trials (Video) Pharmacologic Treatment of Dementias (Video) Drug Development and FDA Review Process (Video) Biomarkers & Biomarker Development (Video) Non-Pharmacologic Interventions (Video) |
December 2020
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Dementia Genetics Companion story: The Early ADRC’s Search for an Alzheimer’s Gene Friday - 12/11/20 - 12:00-1:30 |
Faculty Guides:
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Dementia for Scientists Curriculum Genetics of Alzheimer's Disease (Video) Genetic Risks and Genetics in Clinical Practice (Video) Genetics and Pathogenesis of Amyotrophic Lateral Sclerosis & Frontotemporal Dementia (Video) Ethical Issues in Neurogenetic Conditions (Video) |
October 2020
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Dementia Definition and Evaluation Friday - 10/23/20 - 12:00-1:30 |
Faculty Guides: |
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Dementia for Scientists Curriculum Defining Dementias, Clinical Features, Natural History (Video) Neuropsychology of Alzheimer's Disease and Mild Cognitive Impairment (Video) Clinical Evaluation of Dementias Part 1 (Video) Clinical Evaluation of Dementias Part 2 (Video) Behavioral & Psychiatric Features of Dementia Part 1 (Video) Behavioral & Psychiatric Features of Dementia Part 2 (Video) |
September 2020
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Dementia Pathology and Pathogenesis Friday - 9/25/20 - 12:00-1:30 |
Faculty guides |
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Dementia for Scientists Curriculum
Alzheimer's Disease - The amyloid cascade, alternative mechanisms (Video) Alzheimer's Disease - Amyloidopathy (Video) Alzheimer's Disease - Tau Biology and Pathology (Video) Lewy Body Dementia - Synucleinopathies & Synuclein (Video) Vascular Dementias (Video) Pathology of Dementia, Degenerative and Spinal Cord Diseases (Video) |
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Book discussion: Can You Help Me?: Inside the Turbulent World of Huntington Disease with Thomas D. Bird, MD, Professor Emeritus, UW Medicine, UW Department of Neurology, Chief, UW Division of Neurogenetics Friday - 1/27/23 - 12:00-1:30 pm |
Faculty Guides: Thomas Bird, MD
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