Past Pilots

Funding Source	Principal Investigator Department	Funding Period	Project title
P30 CFRTC	Beno Freedman PhD Nephrology	2022-24	Modeling CFTR function with human kidney organoids
CFF RDP	Eric Morrell, MD Pulmonary	2021-24	Role of Soluble PD-L1 in Chronic Lung Allograft Dysfunction
CFF RDP	Amy Willis, PhD Biostatistics	2021-23	Estimating the composition of the cystic fibrosis pulmonary microbiome
P30 CFRTC	Pavan Bhatraju, MD Pulmonary	2018-23	Identification of Predictive Biomarkers for Antibiotic Associated Nephrotoxicity in Cystic Fibrosis
P30 CFRTC	Jim Kublin, MD, MPH Vaccine & ID, Hutch	2020-23	Investigating Mechanisms of Vaccine Response Deficiency in Cystic Fibrosis
P30 CFRTC	Sakeneh Zraika, PhD Metabolism	2020-23	Impact of Intra-Islet GLP-1 Signaling on ß-cell Function in CFRD
CFF RDP	Eric Morrell, MD, MA Pulmonary	2019-22	Immune Tolerance and Inflammation in Lung Transplant Rejection
CFF RDP	David Sherman, PhD Microbiology	2019-21	Inferring drug interactions in M. abscessus using chemo-genomics and orthology
CFF RDP	Richard James, PhD Jason Debley, MD Pediatrics	2019-20	Approach to CFTR Editing in Differentiated Airway Epithelial Cells
P30 CFRTC	Marion Pepper, PhD Immunology	2018-21	Pseudomonas-specific immune responses in CF patients
P30 CFRTC	Jisun Paik, PhD Comparative Medicine Luke Hoffman, MD, PhD, Pediatrics	2018-20	Gastrointestinal dysbiosis as a modifier of CF infant somatic growth: A murine investigation
P30 CFRTC	Steve Salipante, MD, PhD, Lab Medicine	2018-20	Cell-free Bacterial DNA to Identify Mycobacterial Lung Pathogens in CF
CFF RDP	Andrew Graustein, MD Pulmonary	2017-20	The NLRP3 Inflammasome in The Cystic Fibrosis Lung
CFF RDP	Thomas Hawn, MD, PhD Allergy & ID	2017-19	The Inflammasome in Cystic Fibrosis
CFF RDP	Jason Debley, MD David Nichols, MD Pediatrics	2017-19	Testing association between epithelial chloride transport and measures of clinical improvement
P30 CFRTC	Matthew Parsek, PhD Microbiology	2016-20	Microbial colonization and adaptation to the CF gut
P30 CFRTC	Neal Paragas, PhD Nephrology	2016-19	Identification of Biomarkers for Cystic Fibrosis Associated Nephrotoxicity
P30 CFRTC	Lynn Hajjar, DVM, PhD Comparative Medicine	2016-18	Lung and gastrointestinal homeostasis in a germ-free CF mouse model
P30 CFRTC	Marika Bogdani, PhD Benaroya	2016-17	Hyalouronan and hlyaladherins in the pathogenesis of cystic fibrosis related diabetes
CFF RDP	Steve Salipante, MD, PhD, Lab Medicine	2015-18	Mechanisms and fitness of spontaneous aztreonam resistance in Pseudomonas aeruginosa
CFF RDP	William Altemeier, MD Pulmonary	2015-18	Role of the Microvasculature in Neutrophilic Lung Disease of Cystic Fibrosis
P30 CFRTC	Steven Kahn, MB, ChB Metabolism	2014-19	Mechanisms of Late Hypoglycemia in Cystic Fibrosis
P30 CFRTC	Ian de Boer, MD Nephrology	2014-18	Vitamin D metabolism in cystic fibrosis
CFF RDP	Rafael Hernandez, MD, PhD, Pediatrics	2014-17	Efflux Pumps in Nontuberculosis Mycobacteria
P30 CFRTC	Anne Manicone, MD Pulmonary	2014-17	Functional Consequences and Signaling Pathways of Macrophage Repolarization
CFF RDP	Donald Chi, DDS, PhD Dentistry	2013-17	Testing a Multifactorial Caries Model for Pediatric Patients with Cystic Fibrosis
P30 CFRTC	Elhanan Borenstein, PhD, Genome Sciences	2013-14	Advanced computational methods for identifying compositional shifts in the CF gut microbiome
P30 CFRTC	Lucas Hoffman, MD, PhD Pediatrics	2013-14	Acute Effects of Kalydeco in People with CF and the G551D Mutation
P30 CFRTC	Rebecca Hull, PhD Metabolism Srinath Sanda, MD Pediatrics, UCSF	2012-17	Role of Islet Amyloid and IL-1β Signaling in β-cell Loss in Cystic Fibrosis-Related Diabetes
P30 CFRTC	Ian Sweet, PhD Metabolism	2012-15	Biochemical Mechanisms Mediating Impaired Insulin Secretion in Mouse Models of Cystic Fibrosis
P30 CFRTC	Lev Becker, PhD Pediatrics, U Chicago	2012-15	Investigating the effects of CFTR Correction on Myeloid Cell Function
P30 CFRTC	Lev Becker, PhD Pulmonary	2010-13	Macrophage and Dendritic Cell Pathways in Cystic Fibrosis
P30 CFRTC	Lucas Hoffman, MD, PhD Pediatrics	2010-13	Describing the gut microbiome of early childhood and infant Cystic Fibrosis patients