- Core & Center Director, Thomas Montine, MD, PhD
- Core & Center Associate Director, Murray Raskind, MD
- Core & Center Associate Director, Elaine Peskind, MD
- Center Administrator, Molly Chinn
The Administrative Core provides a research culture that facilitates the discovery of new knowledge about Alzheimer's and related dementia disorders and facilitates the application of this knowledge to the development of experimental therapeutics. The Director, Associate Director, and Administrator, in collaboration with the Executive Committee, coordinate and integrate ADRC research components, activities, and resources; solicit exploratory research applications; respond to scientific and public community insight about the relevance of ADRC scientific and educational initiatives; ensure compliance with human subjects policy requirements at the National Institute of Health; and foster interactions with other investigators, Alzheimer's research centers, and the National Alzheimer's Coordinating Center.
- Core Director, Elaine Peskind, MD
- Core Associate Director, Debby Tsuang, MD, MSc
- Core Associate Director, Gail Li, MD, PhD
Because the participants who are appropriate for one type of study are often not appropriate for other types of studies, the Clinical Core carefully screens volunteers into clearly defined participation groups that include age-matched cognitively healthy participants and patients with such disorders as mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, and other related dementias. Clinical Core personnel also support and interact with people with late-life dementia and cognitively healthy participants who may be appropriate for epidemiologic studies and for participation in the UW ADRC autopsy program. The Clinical Core collects spinal fluid, plasma, and serum from these participants, and through multi-ADRC collaborative efforts, expands the UW ADRC spinal fluid bank to support the continued search for Alzheimer's-related biomarkers that may be helpful for diagnosing Alzheimer's, monitoring disease progression, and identifying people who are at risk for dementia disorders even when no symptoms are present.
Neuropathology & Targeted Molecular Testing Core
- Core Director, Thomas Montine, MD, PhD
- Associate Director, Joshua Sonnen, MD
- Associate Director, Chang-En Yu, PhD
The Neuropathology Core provides diagnostic expertise, facilitates research, teaches and mentors trainees, and develops innovative research approaches. In 2003, the UW ADRC Neuropathological Core formed a unique collaboration with the Alzheimer’s Disease Center at Oregon Health & Science University, known collectively as the Pacific Northwest Dementia and Aging Neuropathology (PANDA) Group, which allows the core to better serve the mission of the ADRC. Together, these two neuropathological cores examine targeted spinal fluid biomarkers in the UW ADRC spinal fluid bank and provide targeted genetic testing relevant to Alzheimer’s and related dementing diseases. All of the Neuropathology Core’s activities are focused on enhancing the research value of tissue and body fluid donations from cognitively healthy individuals and patients with dementia disorders like Alzheimer’s.
Data Management & Statistics Core
- Core Director, Ellen Wijsman, PhD
The primary objective of the Data Core is to provide database management and biostatisticial support to the cores, projects, and exploratory projects of the UW ADRC. The Data Core is instrumental in providing ADRC investigators with database and statistical expertise both in the initial project design phase of studies and in later stages, when investigators are preparing manuscripts and performing statistical analyses and interpretations. The activities of Data Core members thereby facilitate the overall goals of the UW ADRC, particularly in its aim to reduce the burden of Alzheimer’s disease.
Education & Information Core
- Core Director, James Leverenz, MD
The Education and Information Core seeks to promote the recruitment and retention of research participants, particularly from minority communities that have been historically underserved by researchers, such as the African American community. To this end, the Education and Information Core operates as the public face of the UW ADRC, actively facilitating community and professional outreach and education programs to increase the exposure of the Center. In these efforts, the Education and Information Core collaborates with the Alzheimer's Association and partners with the African American Advisory Board. Through this important work, the Education and Information Core both enhances the knowledge of the public about Alzheimer's disease and also improves the UW ADRC's recruitment and retention of research participants, including African American participants.