Recent career awards and funding for researchers in the UW Alzheimer’s community
Contact gwanucha@uw.edu to request additions to this list
2021
UW Division of Gerontology & Geriatric Medicine
Regulation of insulin BBB transport by the astrocyte insulin receptor. NIDDK, P30 Supplement, Elizabeth Rhea
MALDI Imaging of glial scar-forming glycans in Alzheimer’s disease. NIH/NIA, R21, Kimberly Alonge (PI) Collaborators: C. Dirk Keene, Caitlin Latimer, Miklos Guttman
TDP-43 in Alzheimer’s disease. NIH/NIA, R01, Nicole Liachko. (PI) Collaborators: C. Dirk Keene, Caitlin Latimer, Paul Valdmanis
Viable Microvessels for the Study of the Microvasculature in Alzheimer’s Disease. NIH/NIA, R21 May Reed (PI) Collaborators: C. Dirk Keene
Effects of apoE Isoform, Sex and Diet on Insulin Regulation in Brain: Investigating the impact of apoE, sex, and age on SARS-CoV-2 blood brain barrier transport and cognitive effects. NIH RO1 supplement, Elizabeth Rhea, William Banks
Effect of Central FGF1Treatment on Perineuronal Net Assembly in Alzheimer's disease. NIH/NIDDK, NOT-DK, Michael W. Schwartz, Kimberly Alonge
Identifying an Ophthalmic Combinatorial Biomarker of Early Alzheimer’s Disease Using Novel Imaging and Deep Learning. Alzheimer’s Drug Discovery Foundation grant, Cecilia S. Lee
Brain glycan sulfation recoding in Alzheimer's disease. UW ADRC 2021-2022 Development Award, Kimberly Alonge Learn More
UW Department of Neurology
“The Brain and Maternal Microchimerism: Characterizing transcriptomal status and phenotype of microchimerism-derived cells in the human brain within the context of refractory epilepsy. NIH/NINDS R21, J. Lee Nelson, Jonathan Weinstein
Multidisciplinary Clinical Research Career Development Award. UW ITHS KL2, Jonathan Weinstein
White Matter Injury and Protection: Mechanisms, Outcomes, and Translational Assessments - Developing methods of assessing white matter integrity and protection in the rodent brain with an emphasis on electrophysiological and magnetic resonance imaging modalities. NIH/NCATS KL2, Ashley McDonough, Jonathan Weinstein (Mentor)
Single Cell RNA sequencing Transcriptomic Analysis of Ischemic Preconditioned Microglia. NIH/NINDS, R03, Jonathan Weinstein
Understanding microglia responses in resilience, cognitive decline, and neuropathological proteopathy. UW ADRC 2021-2022 Development Award, Katherine Prater Learn More
UW Department of Physiology and Biophysics
The Relationship between Inflammation and Cognition in a Monkey Model of Human Aging. NIH Supplement to the Primate Center P51 grant, Beth Buffalo
UW Department of Laboratory Medicine & Pathology
Engineering human brain neurovascular niche for modeling brain diseases. NIA, R21 Ying Zheng, Jessica Young
Mechanisms of sex differences in risk of developing Alzheimer’s disease. NIH/NIA, R01 Jessica Young, Sumie Jayadev, and Christine Disteche. Collaborators: C. Dirk Keene, Joel Berletch. This project represents a collaboration across the Department of Laboratory Medicine and Pathology, Department of Neurology, and the Institute for Stem Cell and Regenerative Medicine (ISCRM)
Cortical Somatostatin Interneuron Dysfunction after Trauma: Role in Cognitive Flexibility. NIH K08 (Career Award Transfer from UCSF), Amber Nolan
Neuroinflammation and Neural Circuit Dysfunction in Traumatic Brain Injury. Martin-Reichenbach Fellowship Award, Amber Nolan
True-Brown Fellowship Award. UW Department of Laboratory Medicine & Pathology, Amber Nolan
High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of Life. NIH R01, C. Dirk Keene
Oligodendrocyte Progenitors and Hyaluronan-mediated Mechanisms of Human Vascular White Matter. NIH RFA, C. Dirk Keene
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI): Identifying the causes, risk factors, biomarkers and prognoses for patients with traumatic brain injury. National Football League, C. Dirk Keene
UW School of Nursing
Development and Useability Evaluation of a Mobile health Intervention to Support Healthful Dietary Choices in Older Persons with Dementia. NIA, K23, Oleg Zaslavsky
Mediterranean Diet App for Individuals with Frailty and/or Dementia, as well as Their Care Partners. de Tornyay Center RIFP, Oleg Zaslavsky
UW Department of Medicine
The Alzheimer’s Disease Sequencing Phenotype Harmonization Consortium. NIA, U24. Leaders: Timothy Hohman (Vanderbilt University), Mike Cuccaro (University of Miami), Jesse Mez (Boston University), Paul K. Crane. The new project will pool these data from more than 30 research cohorts using data harmonization principles that are well established. This will produce a large-scale, racially diverse, standardized set of transparently defined data that will support machine learning and open new windows into the genetic basis of Alzheimer’s disease and Alzheimer’s resiliency. Drs. Paul Crane and Jesse Mez lead the cognitive data harmonization to generate longitudinal composite measures of cognitive performance. Learn More.
UW Department of Psychology
Using Neurocomputational Modeling to Track Memory Decline. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology, Andrea Stocco , Project Lead (Department of Psychology) Thomas Grabowski (UW Neurology, Radiology), Hedderik van Rijn (Department of Experimental Psychology, University of Groningen). Learn More
UW Department of Radiology
Cerebrovascular imaging of mild cognitive impairment with suspected non-amyloid pathology. NIA, K01 Swati Rane (PI)
Pathological mechanisms of white matter hyperintensities. NIA, R01 Swati Rane (PI)
UW Department of Psychiatry and Behavioral Sciences
Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque deposition. NIA, R01 Jeffrey Iliff (PI)
UW Department of Biomedical Informatics and Medical Education
Improving Patient-Focused, Population-Informed Care in Clinical Neurosciences. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology, Sean Mooney (Department of Biomedical Informatics and Medical Education) (Co-Investigator of the UW ADRC Imaging and Biomarker Core), Thomas Grabowski (Departments of Radiology, Neurology), Michael J. Persenaire (Department of Neurology) Learn More
UW College of Engineering
Using Deep Learning to Diagnose Alzheimer's Disease and Predict its Progression. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology, Linda Shapiro (UW College of Engineering) Thomas Grabowski (Departments of Radiology, Neurology), Sheng Wang, PhD (UW College of Engineering) Learn More
The Adult Changes in Thought Study
The Adult Changes in Thought (ACT) Study Research Program. NIA, U19. PIs: Eric B. Larson, Paul K. Crane, Andrea Z. LaCroix (University of California San Diego) Collaborators (UW): Shubhabrata Mukherjee, Laura Gibbons, Thomas Grabowski, Ceclia Lee, Christine MacDonald, C. Dirk Keene, Caitlin Latimer, Jessica Young. Kaiser Permanente Washington, University of Washington, and University of California-San Diego will lead an expanded ACT Program to better understand the aging brain. The overarching goal is to identify risk factors across the life course that provide potential intervention targets for preserving cognition and preventing Alzheimer’s disease and related dementias.
- Project 1: Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle. Dori Rosenberg, Sue McCurry
- Project 2: Cognitively Defined Alzheimer’s Subgroups: Natural history, neuropathology, and life course ramifications. Paul K. Crane, Janelle Taylor (University of Toronto)
- Project 3: Mechanisms underlying neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs. Shelly Gray, Jessica Young
Pregnancy Complications and the Development of Alzheimer’s Disease and Related Dementias in Women in the Adult Changes in Thought study. NIA R21, Eliza C. Miller (Columbia University) (ACT Collaborator)
Washington State University Collaborators
Psychological risk factors, quality of life, community, and brain aging in American Indians. NIA, RF1, Astrid Suchy-Dicey, Celestina Barbosa-Leiker (PIs)
Alzheimer’s disease biomarkers, vascular risk factors and cognitive variability in aging individuals with diabetes type 1. Alzheimer’s Association Research Fellowship to Promote Diversity (AARF-D) Program. Luciana Mascarenhas Fonseca (PI), Naomi S. Chaytor (Mentor)
Plasma phosphorylated tau protein and Alzheimer's disease in American Indians: The Strong Heart Study. UW ADRC 2021-2022 Development Award, Astrid Suchy-Dicey (Washington State University) Learn More
UW Institute for Stem Cell & Regenerative Medicine
Using metabolic network modeling to improve the maturity of iPSC-derived microglia for Alzheimer's disease. UW ADRC 2021-2022 Development Award, Yuliang Wang Learn More
2020
Department of Laboratory Medicine & Pathology
A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer’s disease (NIH, U19) Ed Lein, Thomas Grabowski, C. Dirk Keene, Eric Larson, Paul Crane
Modulation of AD by HSV Infection (NIH, R01) Martin Darvas, Christine Johnston
Molecular mechanisms of synergistic TDP-43 and tau proteotoxicity in Alzheimer’s disease (NIA, K08) Caitlin Latimer
Division of Gerontology & Geriatric Medicine
‘Protection from pathological tau by activation of the ER unfolded protein response (NIA R01) Brian Kraemer
Characterization of a human in vitro blood-brain barrier model to study the effects of systemic aging on responses to Alzheimer’s disease effectors (NIH, R21). Michelle Erickson
2020 Healthy Aging Program to further research on cognitive decline and neurodegenerative disease (Brown Foundation) Elizabeth Rhea, Michelle Erickson, Brian Kraemer
Department of Psychiatry and Behavioral Sciences
Remote Assessment of Cognitive Aging and Mental Health in Older Afrcian Americans During COVID-19. Garvey Institute for Brain Health Solutions, Innovation Grant, Debby Tsuang (Department of Psychiatry and Behavioral Sciences), Ge Li (Department of Psychiatry and Behavioral Sciences), Murray Raskind (Department of Psychiatry and Behavioral Sciences), Edmund Seto (Department of Environmental and Occupational Health Sciences) Learn More
Validating a Non-Invasive Method to Measure Water Transport in Brain Health and Disease. UW Medicine Garvey Institute for Brain Health Solutions, Innovation Grant, Jeffrey Iliff, Deidre Jansson Learn More
Department of Neurology
Understanding the functional impact of cumulative genetic risk in Alzheimer disease (NIH, RF1) Suman Jayadev NIH Description
Lipid MRI Pilot Study (Catalyst Grant) Angela Hanson
Department of Radiology
Synthesizing Positron Emission Tomography (PET) Data from MRI using Deep Learning. Garvey Institute for Brain Health Solutions, Innovation Grant, Hesamoddin Jahanian, Thomas Grabowski Learn More
School of Pharmacy
Antihypertensives and the aging brain (NIA, K76) Zachary Marcum
School of Nursing
Improving the Health and Effectiveness of Caregivers of People with Lewy Body Dementia. Garvey Institute for Brain Health Solutions, Innovation Grant. Oleg Zaslavsky (School of Nursing)
Annie Chen (Department of Biomedical Informatics and Medical Education), Kimiko Domoto-Reilly (Department of Neurology) Learn More
UW ADRC - Weill Neurohub (UC Berkeley/ UC San Francisco)
Foundations and initial neuroimaging applications of NextGen 7T MRI. UCB: Chunlei Liu, David Feinberg; UCSF: Pratik Mukherjee; UW: Thomas Grabowski.
An integrated, patient-focused, and cell-based approach to develop novel therapeutics for Alzheimer’s disease and related disorders. UCSF: William Seeley, Lea Grinberg; UCB: Michael Rape, Jennifer Doudna; UW: C. Dirk Keene, Suman Jayadev, Jessica Young
Weill Neurohub Data and Analytics Center UCSF: Roland Henry, Shrivshankar Sundaram; UCB: Kris Bouchard, Bin Yu; UW: Bing Brunton, Thomas Grabowski
