New Grants & Funding

Recent career awards and funding for researchers in the UW Alzheimer’s community

Contact gwanucha@uw.edu to request additions to this list

 

2021

 

Division of Gerontology & Geriatric Medicine

Effects of apoE Isoform, Sex and Diet on Insulin Regulation in Brain: Investigating the impact of apoE, sex, and age on SARS-CoV-2 blood brain barrier transport and cognitive effects. NIH RO1 supplement, Elizabeth Rhea, William Banks

Effect of Central FGF1Treatment on Perineuronal Net Assembly in Alzheimer's disease. NIH/NIDDK, NOT-DK, Michael W. Schwartz, Kimberly Alonge

Identifying an Ophthalmic Combinatorial Biomarker of Early Alzheimer’s Disease Using Novel Imaging and Deep Learning. Alzheimer’s Drug Discovery Foundation grant, Cecilia S. Lee

Brain glycan sulfation recoding in Alzheimer's disease. UW ADRC 2021-2022 Development Award, Kimberly Alonge Learn More

 

Department of Neurology

“The Brain and Maternal Microchimerism: Characterizing transcriptomal status and phenotype of microchimerism-derived cells in the human brain within the context of refractory epilepsy. NIH/NINDS R21, J. Lee Nelson, Jonathan Weinstein                                                                                               

Multidisciplinary Clinical Research Career Development Award. UW ITHS KL2, Jonathan Weinstein

White Matter Injury and Protection: Mechanisms, Outcomes, and Translational Assessments - Developing methods of assessing white matter integrity and protection in the rodent brain with an emphasis on electrophysiological and magnetic resonance imaging modalities. NIH/NCATS KL2, Ashley McDonough, Jonathan Weinstein (Mentor)

Single Cell RNA sequencing Transcriptomic Analysis of Ischemic Preconditioned Microglia. NIH/NINDS, R03, Jonathan Weinstein

Understanding microglia responses in resilience, cognitive decline, and neuropathological proteopathy. UW ADRC 2021-2022 Development Award, Katherine Prater Learn More

 

Department of Physiology and Biophysics

The Relationship between Inflammation and Cognition in a Monkey Model of Human Aging. NIH Supplement to the Primate Center P51 grant, Beth Buffalo

 

Department of Laboratory Medicine & Pathology

Cortical Somatostatin Interneuron Dysfunction after Trauma: Role in Cognitive Flexibility. NIH K08 (Career Award Transfer from UCSF), Amber Nolan

Neuroinflammation and Neural Circuit Dysfunction in Traumatic Brain Injury. Martin-Reichenbach Fellowship Award, Amber Nolan

 True-Brown Fellowship Award. UW Department of Laboratory Medicine & Pathology, Amber Nolan

High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of Life. NIH R01, C. Dirk Keene

Oligodendrocyte Progenitors and Hyaluronan-mediated Mechanisms of Human Vascular White Matter. NIH RFA, C. Dirk Keene                

Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI): Identifying the causes, risk factors, biomarkers and prognoses for patients with traumatic brain injury. National Football League, C. Dirk Keene 

 

School of Nursing

Mediterranean Diet App for Individuals with Frailty and/or Dementia, as well as Their Care Partners. de Tornyay Center RIFP, Oleg Zaslavsky

 

Department of Psychology

Using Neurocomputational Modeling to Track Memory Decline. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology, Andrea Stocco , Project Lead (Department of Psychology) Thomas Grabowski (UW Neurology, Radiology),  Hedderik van Rijn (Department of Experimental Psychology, University of Groningen). Learn More

 

Department of Biomedical Informatics and Medical Education

Improving Patient-Focused, Population-Informed Care in Clinical Neurosciences. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology,  Sean Mooney (Department of Biomedical Informatics and Medical Education) (Co-Investigator of the UW ADRC Imaging and Biomarker Core),  Thomas Grabowski  (Departments of Radiology, Neurology), Michael J. Persenaire (Department of Neurology) Learn More

 

College of Engineering

Using Deep Learning to Diagnose Alzheimer's Disease and Predict its Progression. Garvey Institute for Brain Health Solutions, Innovative Uses of Technology,  Linda Shapiro (UW College of Engineering) Thomas Grabowski  (Departments of Radiology, Neurology), Sheng Wang, PhD (UW College of Engineering) Learn More

 

The Adult Changes in Thought Study

Pregnancy Complications and the Development of Alzheimer’s Disease and Related Dementias in Women in the Adult Changes in Thought study. NIA R21, Eliza C. Miller (Columbia University) (ACT Collaborator)

 

Partnerships for Native Health - Washington State University

Plasma phosphorylated tau protein and Alzheimer's disease in American Indians: The Strong Heart Study. UW ADRC 2021-2022 Development Award, Astrid Suchy-Dicey (Washington State University) Learn More

 

UW Institute for Stem Cell & Regenerative Medicine

Using metabolic network modeling to improve the maturity of iPSC-derived microglia for Alzheimer's disease. UW ADRC 2021-2022 Development Award, Yuliang Wang Learn More

 

 

2020

 

Department of Laboratory Medicine & Pathology

A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer’s disease (NIH, U19) Ed Lein, Thomas Grabowski, C. Dirk Keene, Eric Larson, Paul Crane

Modulation of AD by HSV Infection (NIH, R01) Martin Darvas, Christine Johnston

Molecular mechanisms of synergistic TDP-43 and tau proteotoxicity in Alzheimer’s disease (NIA, K08) Caitlin Latimer 

 

Division of Gerontology & Geriatric Medicine

‘Protection from pathological tau by activation of the ER unfolded protein response (NIA R01) Brian Kraemer

Characterization of a human in vitro blood-brain barrier model to study the effects of systemic aging on responses to Alzheimer’s disease effectors (NIH, R21). Michelle Erickson

2020 Healthy Aging Program to further research on cognitive decline and neurodegenerative disease (Brown Foundation) Elizabeth Rhea, Michelle Erickson, Brian Kraemer

 

Department of Psychiatry and Behavioral Sciences

Remote  Assessment of Cognitive Aging and Mental Health in Older Afrcian Americans During COVID-19. Garvey Institute for Brain Health Solutions, Innovation Grant, Debby Tsuang (Department of Psychiatry and Behavioral Sciences), Ge Li (Department of Psychiatry and Behavioral Sciences), Murray Raskind (Department of Psychiatry and Behavioral Sciences), Edmund Seto (Department of Environmental and Occupational Health Sciences) Learn More

Validating a Non-Invasive Method to Measure Water Transport in Brain Health and Disease. UW Medicine Garvey Institute for Brain Health Solutions, Innovation Grant, Jeffrey Iliff, Deidre Jansson Learn More

 

Department of Neurology

Understanding the functional impact of cumulative genetic risk in Alzheimer disease (NIH, RF1) Suman Jayadev NIH Description

Lipid MRI Pilot Study (Catalyst Grant) Angela Hanson

 

Department of Radiology

Synthesizing Positron Emission Tomography (PET) Data from MRI using Deep Learning. Garvey Institute for Brain Health Solutions, Innovation Grant, Hesamoddin Jahanian, Thomas Grabowski Learn More

 

School of Pharmacy

Antihypertensives and the aging brain (NIA, K76) Zachary Marcum

 

School of Nursing

Improving the Health and Effectiveness of Caregivers of People  with Lewy Body Dementia. Garvey Institute for Brain Health Solutions, Innovation Grant. Oleg Zaslavsky (School of Nursing)
Annie Chen (Department of Biomedical Informatics and Medical Education), Kimiko Domoto-Reilly (Department of Neurology) Learn More 

 

UW ADRC - Weill Neurohub (UC Berkeley/ UC San Francisco)

Foundations and initial neuroimaging applications of NextGen 7T MRI. UCB: Chunlei Liu, David Feinberg; UCSF: Pratik Mukherjee; UW: Thomas Grabowski. 

An integrated, patient-focused, and cell-based approach to develop novel therapeutics for Alzheimer’s disease and related disorders. UCSF: William Seeley, Lea Grinberg; UCB: Michael Rape, Jennifer Doudna; UW: C. Dirk Keene, Suman Jayadev, Jessica Young 

Weill Neurohub Data and Analytics Center  UCSF: Roland Henry, Shrivshankar Sundaram; UCB: Kris Bouchard, Bin Yu; UW: Bing Brunton, Thomas Grabowski

Project Descriptions