Blood-Based Biomarkers for Alzheimer’s Disease in the Primary Care Space

UW ECHO Dementia August 22, 2025:  Blood-Based Biomarkers for Alzheimer's Disease in the Primary Care Space

Elif Sozmen, MD, PhD, Center for Healthy Aging, Women's Brain Health Program, Swedish Neuroscience Institute

 

Recording Slides

 

Resources: 

• AAFP Early Detection of Alzheimer's Disease and Related Dementias: Guidance on Shared Decision Making

 

• Mielke MM, Anderson M, Ashford JW, et al. Recommendations for Clinical Implementation of Blood-Based Biomarkers for Alzheimer's Disease. Alzheimer's Dement. 2024;20(11):8216-8224.

 

• Galasko DR, Grill JD, Lingler JH, et al. Symptomatic Subcommittee of the Advisory Group on Risk Evidence Education for Dementia (AGREEDementia). A blood test for Alzheimer's Disease: It's about time or not ready for prime time? J Alzheimers Dis. 2022;90(3):963-966.

 

• Mielke MM, Fowler NR. Alzheimer Disease Blood Biomarkers: Considerations for Population-Level Use. Nat Rev Neurol. 2024;20(8):495-504.

 

• Pais MV, Forlenza OV, Diniz BS. Plasma Biomarkers of Alzheimer's Disease: A Review of Available Assays, Recent Developments, and Implications for Clinical Practice. J Alzheimers Dis Rep. 2023;7(1):355-380.

 

• Palmqvist S, Warmenhoven N, Anastasi F. et al. Plasma Phospho-tau-217 for Alzheimer's Disease Diagnosis in Primary and Secondary Care Using a Fully Automated Platform. Nat Med 31, 2036-2043 (2025).

 

• Petersen RC, Lopez O, Armstrong MJ, et al. Practice Guideline Update Summary: Mild Cognitive Impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126-135.