Biomarkers

ADRC Director Dr. Thomas Grabowski discusses brain scans with a research participant. Learn more. UW Medicine/KOMO News

The Importance of Biomarkers

Biomarkers are substances or characteristics that are used as indicators of biological states. Some examples are elevated PSA levels, which may indicate prostate cancer, and elevated blood pressure readings, which may indicate high blood pressure. These measurable substances help us diagnose disease, create individualized treatment plans, and ultimately, develop standards for evaluating the effectiveness of treatments. They are the signposts that guide our long and complicated journey toward finding medications, preventive strategies, and cures for Alzheimer’s disease.

What are Biomarkers of Alzheimer's Disease?

Research into biomarkers for Alzheimer’s disease is an important focal point of the ADRC’s past and current research and exploration.

Biomarkers are measurable markers in the blood, spinal fluid, levels of amyloid or tau pathology in the brain, patterns of brain activity on functional MRI scan, or scores on cognitive tests. Our research aims to identify specific biomarkers that definitively indicate whether people have Alzheimer’s disease or whether they may be at risk of developing dementia sometime in the future.

We hope that by identifying biomarkers for Alzheimer’s disease we will be able to accurately tailor Alzheimer’s treatments and recognize people who may be good candidates for prevention treatments-the hallmark of a precision medicine approach. Tracking changes in biomarkers over time can help researchers to monitor a disease’s path through the brain, or the effect of a therapeutic during a clinical trial.

Biomarker Research at the ADRC

Magnetic Resonance Imaging (MRI)

Our team runs the Therapeutic Pipeline Project's Dynamic Functional Connectivity MRI in Preclinical AD, an imaging study led by Drs. Tom Grabowski and Tara Madhyastha. They aim to evaluate the potential of MRI and amyloid PET scans- images of brain structure and activity- to serve as a tool of diagnosis or to track disease progression.

Tau PET Imaging

A recent new tool in biomarker research at the UW is tau imaging - a method of positron emission tomography PET scanning that reveals the pattern of accumulation of tau (a pathology present in several neurodegenerative diseases) in the brains of living people. Tau imaging is poised to have huge implications for understanding and diagnosing FTD and Alzheimer disease and monitoring the effectiveness of drugs targeting tau.

Cerebrospinal Fluid

We have long focused on cerebrospinal fluid (CSF), a fluid surrounding and inside the brain and spinal cord that provides basic mechanical and immune protection for the brain. CSF is a clear, water-like substance that can tell us a variety of details about the changes that may be occurring in a person’s brain. Our researchers collect CSF by conducting research lumbar punctures. The ADRC Clinical Core maintains a bank of CSF, plasma, and serum samples from well-characterized participants with normal and pathological aging, prodromal and diagnosed Alzheimer's, and other neurodegenerative dementias. CSF, plasma, and serum samples are provided to ADRC, other UW, and other Alzheimer's disease investigators nationally for development of biomarkers for assisting in the differential diagnosis of dementia, following disease progression and treatment response, and identifying persons at risk for dementia.