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Thomas D. Bird, M.D.

Position: Professor

Qualifications:

• B.A., Dartmouth College, Hanover, NH, Psychology, 1964.
• M.D., Cornell Medical College, NYC, Medicine, 1968.

Past Positions:

• 2000-present, University of Washington, Neurology, Neurogenetics Division, Head
• 1997-present, Seattle VA, GRECC, Research Neurologist
• 1996-present, University of Washington, Neurology, Professor
• 1988-1997, Seattle VAMC, Neurology, Chief
• 1988-present, University of Washington Medical School, Neurology and Medical Genetics, Professor
• 1984-1988, Seattle VAMC, Neurology, Acting Chief
• 1984-88, University of Washington Medical School, Neurology, Associate Professor
• 1978-84, Seattle VAMC, Neurology, Assistant Chief
• 1978, American Board of Psychiatry and Neurology, Board Certified
• 1976-80, University of Washington, Neurology, Assistant Professor
• 1974-76, University of Washington, Medical Genetics, Special NIH Fellow
• 1969-70, 1972-74, University of Washington, Neurology Resident
• 1970-72, U.S. Navy Medical Corps, San Diego, Lt. Cmdr.
• 1968-69, University of Washington Affiliated Hospitals, Intern

Honors and Awards:

• 2001, Jacoby Award, American Neurological Association
• 1995, Metropolitan Life Foundation Award
• 1992, Wartenberg Lecturer, American Academy of Neurology

Selected Publications:

• Chen D-H, Brkanac Z, Verlinda C, Tan X-J, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino P, Bird T, Raskind W. Missense Mutations in the Regulatory Domain of PKC?: A Novel Mechanism for Dominant Cerebellar Ataxia. Am J Hum Gen, 72:839-849, 2003.
• Street, V.A., Bennett, C.L., Goldy, J.D., Shirk, A.J., Kleopa, K.A., Tempel, B.L., Lipe, H.P., Scherer, S.S., Bird, T.D., Chance, P.F. Mutation of putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. Neurology, 60:22-26, 2003.
• Poorkaj, P., Muma, N., Zhukareva, V., Cochran, E., Shannon, K., Hurtig, H., Koller, W., Bird, T., Torjanowski, J., Lee, M., Schellenberg, G.: An R5L ? Mutation in a Subject with a Progressive Supranuclear Palsy Phenotype. Ann Neurol, 52:511-516, 2002.
• Tsuang, D.W., Dalan, A.M., Eugenio, C.J., Steinbart, E.J., Bird, T.D., Leverenz, J.B.: Familial Dementia with Lewy Bodies: A Clinico-neuropatholgical Study of Two Families. Arch Neurol, 59: 1622-1630, 2002.
• Brkanac, Z., Bylenok, L., Fernandez, M., Matsushita, M., Lipe, H., Wolff, J., Nochlin, D., Raskind, W.H., Bird, T.D.: A New Dominant Spinocerebellar Ataxia is Linked to Chromosome 19q13.4-qter. Arch Neurol, 59:1291-1296, 2002.
• Brkanac, Z., Fernandez, M., Matsushita, M., Lipe, H., Wolff, J., Bird, T.D. and Raskind, W.H.: Autosomal Dominant Sensory/Motor Neuropathy with Ataxia (SMNA): Linkage to Chromosome 7q22-q32. Am. J. Med. Genet. (Neuropsych. Section), 114: 450-457, 2002.
• Street, V.A., Goldy, J.D., Golden, A.S., Tempel, B.L., Bird, T.D. and Chance, P.F.: Mapping of Charcot-Marie-Tooth Disease Type 1C Identifies a Novel Locus for Demyelinating Neuropathies on Chromosome 16p. Am J Hum Genet, 70:244-250, 2002.
• Fernadez, M., Raskind, W., Matsushita, M., Wolff, J., Lipe, H., Bird, T. Hereditary Benign Chorea: Clinical and Genetic Features of a Distinct Disease. Neurology, 57: 106-110, 2001.
• Fernandez, M., Raskind, W., Wolff, J., Matsushita, M., Yuen, E., Graf, W., Lipe, H., Bird, T. Familial Dyskinesia and Facial Myokymia (FDFM): a Novel Movement Disorder. Ann Neurol, 49:486-492,2001.
• Poorkaj, P., Grossman, M., Nemens, E., Payami, H., Sadovnick, A., Nochlin, D., Henderson, V.W., Tabira, T., Trojanowski, J.Q., Borson, S., Galasko, D., Reich, S., Quinn, B., Schellenberg, G., Bird, T.D. The Frequency of Tau Gene Mutations in Familial and Sporadic Cases on Non-Alzheimer Dementia. Arch Neurol, 58:383-387, 2001.
• Lippa, C.F., Swearer, J.M., Kane, K.J., Nochlin, D., Bird, T.D., Ghetti, B., Nee, L.E., St. George-Hyslop, P., Pollen, D.A. Familial Alzheimer's Disease: Site of Muation Influences Clinial Phenotype. Ann Neurol, 9;14:2125-2130, 2000.
• D'Souza, I.A., Poorkaj, P., Hong, M., Nochlin, D., Lee, V.M.Y., Bird, T.D., Schellenberg, G.D.: Missense and silent tau gene mutations cause frontotemporal dementia with Parkinsonism, chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc. Natl. Acad. Sci., 96:5598-5603, 1999.
• Koob, M.D., Moseley, M.L., Schut, L.J., Benzow, K.A., Bird, T.D., Day, J.W., Ranum, L.P.W.: An untranslated CTG expansion causes a novel form of spinocellar ataxia. Nature Genetics, 21:1-6,1999.
• Bird, T.D., Nochlin, D., Poorkaj, P., Cherrier, M., Kaye, J., Payami, H., Peskind, E., Lampe, T.H., Nemens, E., Boyer, P.J., Schellenberg, G.D.: A clinical pathological comparision of thre families with Frontotemporal dementia and identical mutations in the tau gene (P301L). Brain, 122:741-756, 1999.
• Benson, K.F., Horwitz, M., Richards, R.I., Mangelsdorf, M., Wolff, J., Raskind, W.H., Bird, T.D.: Analysis of autosomal dominant familial spastic paraparesis families for CAG repeat expansion at common loci identifies novel expansion in a subset of patients. Hum Molc. Gen., 7:1779-1786, 1998.
• Raskind, W.H., Bolin, T., Wolff, J., Fink, J., Matsushita, M., Litt, M., Lipe, H.P., Bird, T.D.: Futher localization of a gene for Paroxusmal Dystonic Choreathetosis to a 5 cM region on chromosome 2q34. Human Genetics, 102:93-97, 1998.
• Moseley, M.L., Benzow, B.A., Schut, L.J., Bird, T.D., Gomez, C.M., Barkhaus, P.E., Blindauer, K.A., Labuda, M., Pandolfo, M., Koob, M.D., Ranum, L.P.W.: Incidence of dominant spinocerebellar and Friedreich triplet repeats among 361 ataxia families. Neurology, 51:1666-1671, 1998.
• Hong, M., Zhukareva, V., Vogelsberg-Ragaglia, V., Wszolek, Z., Reed, L. Miller, B.I., Geschwind, D.H., Bird, T.D., McKeel, D., Goate, A., Morris, J.C., Wilhelmsen, K.C., Schellenberg, G.D., Trojanowski, J.Q., Lee, V.M.Y.: Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science, 282:1914-1917, 1998.
• Poorkaj, P., Bird, T.D.,Wijsman, E., Nemens, E.J., Garruto, R.M., Anderson, L., Andreadis, A., Wiederholt, W.C., Raskind, M., Schellenberg, G.D.: Tau is a candidate for chromosome 17 frontotemporal dementia. Annals of Neurology, 43:815-825, 1998.
• Garbern, J.Y., Cambi, F., Tang, X.M., Sima, A.A.F., Vallat, J.M., Bosch, E.P., Lewis, R., Shy, M., Sohi, J., Kraft, G., Chen, K.L., Joshi, I., Leonard, D.G.B., Johnson, W., Raskind, M., Clouhy, S.R., Pratt, V., Hodes., M.E., Bird, T.D.: The null phenotype demonstrates proteolipid protein (PLP) is requires for peripheral as well as central myelin function. Neuron, 19:205-218,1997.
• Raskind, W.H., Pericak-Vance, M.A., Lennon, F., Wolff, J., Lipe, H.P., Bird, T.D.: Familial spastic paraparesis: Evaluation of locus hetergeneity, anticipated and haplotype mapping of the SPG4 locus on the short arm of chromosome 2. Am J Med Genet, 74:26-36, 1997.
• Graf, W.D., Chance, P.F., Lensch, M.W., Eng, L.J., Lipe, H.P., Bird, T.D.: Severe vincristine neuropathy in CMT 1A patients. Cancer, 77:1356-1362, 1996.
• Levy-Lahad, E., Wasco, W., Poorkaj. P., Romano, D.M., Oshima, J., Pettingell, W.H., Yu, C., Jondro, P.D., Schmidt, S.D., Wang, K., Crowley, A.C., Fu, Y.H., Guenette, S.Y. Galas, D., Nemens, E., Wijsman, E.M., Bird, T.D., Schellenberg, G.D., Tanzi, R.E.: Canididate gene for the chromosome 1 familial Alzheimer's disease locus. Science, 269:973-977, 1995.
• Levy-Lahad, E., Wijsman, E.M., Nemens, E., Anderson, L., Goddard, K.A.B., Weber, J.L., Bird, T.D., Schellenberg, G.D.: A familial Alzhiemer's disease locus on chromosome 1. Science, 269:970-973, 1995.
• Bird, T.D.: Clinical genetics of familial Alzheimer disease. In: Terry, R.D., Katzman, R., Bick, K.L., eds. Alzheimer Disease. New York: Raven Press, p. 65-74, 1994.
• Bird, T.D., Nemens, E.J., Kukull, W.A.: Conjugal Alzheimer's Disease: Is there an increased risk in offspring? Ann Neurol, 34:396-399, 1993.
• Hayasaka, K., Himoro, M., Sato, W., Takada, T., Uyemura, K., Shimizu, N., Bird, T.D., Connealy, P.M., Chance, P.F.: Charcot-Marie-Tooth neuropathy Type 1B is associated with mutations in the myelin Po gene. Nature Genetics, 5:31-34, 1993.
• Chance, P.F., Alderson, M.D., Leppig, K., Lensch, M.W., Matsunami, N., Smith, B., Swanson, P.D., Odelberg, S., Distech, C.M., Bird, T.D.: DNA deletion is associated with hereditary neuropathy with liability to pressure palsies. Cell, 72:143-151, 1993.
• Schellenberg, G.D., Bird, T.D., Wijsman, J.L., Alonso, E., Potter, H., Heston, L.L., Martin, G.M.: Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science, 258:668-671, 1992.
• Sumi, S.M., Bird, T.D., Nochlin, D., Raskind, M.A.: Familial resenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala. Neurology, 42:120-127, 1992.
• Schellenberg, G.D., Anderson, L., L'Dahl, S., Wijsman, E.M., Sadovnick, A.D., Ball, M.J., Larson, E.B., Kukull, W.A., Martin, G.M., Roses, A.D., Bird, T.D.:APP717, APP693, and PRIP gene mutations are rare in Alzheimer's disease. Am. J. Hum. Gen., 49:511-517, 1991.
• Lebo, R.B., Chance, P.F., Dyck, P.U., Redila-Flores, M.T., Lynch, E.D., Golbus, M.S., Bird, T.D., et al: Chromosome 1 Charcot-Marie-Tooth disease (CMT1b) locus in Fcy receptor gene regions. Hum. Gen. , 88:1-12, 1991.
• Schellenberg, G.D., Pericak-Vance, M.A., Wijsman, E.M., Moore, D.L., Gaskell, Jr., P.C., Yamaoka, L.A., Bebout, J.L., Anderson, L., Welsh, K.A., Clark, C.M., Martin, G.M., Roses, A.D., Bird, T.D.: Linkage analysis of familial Alzheimer's disease using chromosome 21 markers. Am. J. Hum. Gen., 48:563-583, 1991.
• Hsiao, K.K., Cass, C., Schellenberg, G., Bird, T.D., Devine-Gage, E., Prusiner, S.D.: A prion protein variant in a family with the telecephalic form of Gerstmann-Straussler-Scheinker syndrome. Neurology, 4:681-684, 1991.
• Raskind, W.H., Wijsman, E., Pagon, R.A., Cox, T.C., Bawden, M.J., May, B.K., Bird, T.D.: X-linked siderblastic anemia and ataxia: linkage to phosphoglycerate kinase at Xq13. Am. J. Hum. Gen., 48:335-341, 1991.
• Chance, P.F., Bird, T.D., O'Connell, P., Lipe, H., LaLouel, J-M., Leppert, M.: Genetic linkage and heterogeneity in Type I Charcot-Marie-Tooth disease. Am. J. Hum. Gen., 47:915-925, 1990.
• Hamilton, S.R., Chatrian, G.D., Mills, R.P., Kalina, R.E., Bird, T.D.: Cone dysfunction in a subgroup of patients wtih autosomal dominant cerebellar ataxia. Arch. Ophthal., 108:551-555, 1990.
• Eto, K., Sumi, S.M., Bird, T.D., McEvoy-Bush, T., Boehnke, M., Schellenberg, G.: Family with dominantly inherited ataxia, amyotrophy and sensory neuropathy. Arch. Neur., 47:968-974, 1990.
• Nochlin, D., Sumi, S.M., Bird, T.D., Snow, A.D., Leventhal, C.M., Beyreuther, K., Gerstmann-Straussler syndrome. Neurology, 39:910-918, 1989.
• Bird, T.D., Sumi, S.M., Nemens, E.J., Nochlin, D., Schellenberg, G., Lampe, T.H., Sadovnick, A., Chui, H., Miner, G.W., Tinklenberg, J.: Phenotypic heterogeneity in familial Alzheimer's disease: a study of 24 kindreds. Ann. Neurol., 25:15-25, 1989.
• Schellenberg, G.D., Bird, T.D., Wijsman, E.M., Moore, D.K., Boehnke, M., Bryant, E.M., Lampe, T.H., Nochlin, D., Sumi, S.M., Deeb, S.S., Beyreuther, K., Martin, G.M.: Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241:1507-1510, 1988.
• Bird, T.D., Lampe, T.H., Nemens, E.J., Miner, G.D., Sumi, S.M., Schellenberg, T.D.: Familial Alzheimer's disease in American descendents of the Volga Germans: probable genetic founder effect. Ann. Neurol., 23:25-31, 1988.
• Chance, P.F., Murray, J.C., Bird, T.D., Kochin, R.: Linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers. Neurology, 37:325-329, 1987.
• Pagon, R.A., Bird, T.D., Better, J.C., and Pierce, L.: Hereditary siderobliastic anemia and ataxia: an X-linked recessive disorder. J. Med. Genet., 22:267-273, 1985.
• Bird, T.D., Ott, J., Giblett, E.R., Chance, P.F., Sumi, S.M., and Kraft, G.H.: Genetic evidence for heterogeneity in Charcot-Marie-Tooth, neuropathy (HMSN-Type I). Ann. Neurol., 14:679-784, 1983.
• Bird, T.D., Gollett, C., and Griep, E.: Cognitive and perfonality function in mytonic muscular dystrophy. J. Neurol, Neurosurg. Psych., 47:971-980, 1983.
• Bird, T., Koerker, R., Leaird, B.J., Vlcek, B., and Thorning, D.R.: Lipmembranous polysystic osteodyplasia (Brain, bone, and fat disease): A genetic cause of presenile dementia. Neurology, 33:8190, 1983.
• Bird, T.D., Ott. J., and Giblett, E.R.: Evidence for linkage of Charcot-Marie-Tooth neuropahthy to the Duffy locus on chromosome 1. Am. J. Hum. Gen. 34:388-394, 1982.