ADRC Home >> About the ADRC >> ADRC Faculty >> Gerard D. Schellenberg

Gerard D. Schellenberg, Ph.D.

Position: Research Professor

Qualifications:

• B.S., University of California at Riverside, Riverside, California, Biochemistry, 1973
• Ph.D., University of California at Riverside, Riverside, California, Biochemistry, 1978

Past Positions:

• 2000-present: Adjunct Research Professor, Division of Neurogenetics, Department of Neurology, University of Washington
• 1996-present: Adjunct Research Professor, Department of Neurology, University of Washington
• 1995-present: Associate Director for Research, Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division
• 1995-present: Research Professor, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington
• 1995-present: Adjunct Research Professor, Department of Pharmacology, University of Washington
• 1990-1995: Research Associate Professor, Division of Neurology, Department of Medicine, University of Washington
• 1983-1990: Research Assistant Professor, Division of Neurology, Department of Medicine, University of Washington
• 1982-1983: Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington
• 1979-1982: Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington
• 1978-1979: Senior Research Fellow, Department of Medical Genetics,University of Washington

Selected Publications:

• Devlin, B., Bennett, P., Dawson, G., Figlewicz, D.A., Grigorenko, E.L., McMahon, W., Minshew, N., Pauls, D., Smith, M., Spence, M.A., Rodier, P.M., Stodgell, C.J., the CPEA Genetics Network, Schellenberg, G.D. (2003) Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA Network. Am. J. Med. Genet. (in press)
• Kraemer, B.C., Zhang, B., Leverenz, J.B., Thomas, J.H., Trojanowski, J.Q., Schellenberg, G.D. (2003) Neurodegeneration and defective neurotransmission in a C. elegans model of tauopathy. Proc. Natl. Acad. Sci. USA 100, 9980-9985.
• Poorkaj, P., Muma, N.A., Zhukareva, V., Cochran, E.J., Shannon, K. M., Hurtig, H., Koller, W.C., Bird, T.D., Trojanowski, J.Q., Lee, V. M.-Y., Schellenberg, G.D. (2002) A R5L tau mutation in a subject with a progressive supranuclear palsy phenotype. Ann. Neurol. 52, 511-516.
• D'Souza, I, Schellenberg, G.D. (2002) Tau exon 10 expression involves a bipartite intron 10 regulatory sequence and a weak 3' splice site. J. Biol. Chem. 277, 26587-26599.
• Devlin, B., Bennett, P., Cook, E. H., Dawson, D., Grigorenko, E. L., McMahon, W., Pauls, D., Spence, M. A., the CPEA Genetics Network, Schellenberg, G. D. (2002) No evidence for linkage of liability to autism to HOXA1 in a Sample from the CPEA Network. Am. J. Med. Genet. 114, 667-672.
• Yu, C.-E., Dawson, G., Munson, J., D'Souza, I., Osterling, J., Estes, A., Leutenegger, A.-L., Flodman, P., Smith, M., Raskind, W.H., Spence, M.A., McMahon, W., Wijsman, W.M., Schellenberg, G.D. (2002) Presence of Large Deletions in Autism Kindreds, Am. J. Hum. Genet. 71, 100-115
• Galasko, D., Salmon, D. P., Craig, U.-K., Thal, L.J., Schellenberg, G.D., Wiederholt, W. (2002) Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000. Neurology 58, 90-97.
• Poorkaj, P., Tsuang, D., Wijsman, E. M., Nemens, E., Garruto, R. M., Craig, U., Anderson, L.-J., Bird, T. D., Plato, C. C., Weiderholt, W., Galasko, D., Schellenberg, G. D. (2001) Tau is a candidate gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam. Arch. Neurol. 58, 1871-1879.
• Tsuang, D.W., Skol, A., Faraone, S.V., Bingham, S., Young, K.A., Prabhudesai, S., Haverstock, S.L., Mena, F., Menon, A.S., Bisset, D., Pepple, J., Johnson, J., Baldwin, C., Weiss, D., Collins, J, Boehnke, M., Schellenberg, G.D., Tsuang, M.T. (2001) Examination of genetic linkage of chromosome 15 to schizophrenia in a large veterans affairs cooperative study sample. Am. J. Med. Genet. 105, 662-668.
• Poorkaj, P., Kas, A., D'Souza, I., Zhou, Y., Pham, O., Olson, M.V., Schellenberg, G.D. (2001) Comparison of the Genomic Sequences Encoding the Mouse and Human Microtubule Associated Protein Tau. Mammalian Genome 12, 700-712
• Poorkaj, P., Grossman, M., Nemens, E., Payami, H., Sadovnick, A., Nochlin, D., Henderson, V. W., Tabira, T., Trojanowski, J. Q., Borson, S., Galasko, D., Reich, S., Quinn, B., Schellenberg, G., Bird, T. D. (2001) The frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch. Neurol. 58, 383-387.
• Daw, E.W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T.D., Schellenberg, G.D., Wijsman, E. M. (2000) The number of trait loci in late-onset Alzheimer disease. Am. J. Hum. Genet. 66, 196-204
• Brophy, V. H., Jarvik, G. P., Richter, R. J., Rozek, L. S., Schellenberg, G. D., Furlong, C. E. (2000) Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 10, 453-460.
• Poorkaj, P., Peterson, K.R., Schellenberg, G.D. (2000) Single-step conversion of P1 and P1 artificial chromosome clones into yeast artificial chromosomes. Genomics 68, 106-110.
• D'Souza, I., Schellenberg, G. D. (2000) Determinants of 4 repeat tau expression: Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion. J. Biol. Chem. 275, 17700-17709.
• Daw, E.W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T.D., Schellenberg, G.D., Wijsman, E. M. (2000) The number of trait loci in late-onset Alzheimer disease. Am. J. Hum. Genet. 66, 196-204.
• D'Souza, I, Poorkaj, P., Hong, M., Nochlin, D., Lee, V. M.-Y., Bird, T. D., Schellenberg G. D. (1999) Missense and Silent Tau Gene Mutations Cause Fronto Temporal Dementia with Parkinsonism - Chromosome 17 Type by Affecting Multiple Alternative RNA Splicing Regulatory Elements. Proc. Natl. Acad. Sci. USA 96, 5598-5603.
• Bird, T. D., Nochlin, D., Poorkaj, P., Cherrier, M., Kaye, J., Payami, H., Peskind, E., Lampe, T. H., Vonsattel, J. P., and Schellenberg, G. D. (1999) A clinical pathological comparison of three families with fronto-temporal dementia and identical mutations in the tau gene (P301L). Brain 122,741-756
• Hong, M., Zhukareva, V., Vogelsberg-Ragaglia, V., Wszolek, Z., Reed, L., Geschwind, D. H., Bird, T. D., McKeel, D., Morris, J. C., Wilhelmsen, K. C., Schellenberg, G. D., Trojanowski, J. Q., Lee, V. M.-Y. (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary frontotemporal dementia and Parkinsonism linked to chromosome 17: Genotype predicts phenotype. Science 282, 1914-1917
• Clark, L. N., Poorkaj, P., Wszolek, Z., Geschwind, D. H., Nasreddine, Z. S., Miller, B., Payami, H., Awert, F., Markopoulou, K., D'Souza, I., Lee, V M.-Y., Trojanowski, J., Zhukareva, V., Bird, T. D., Schellenberg, G. D., and Wilhelmsen, K. C. (1998) Pathologic implications of mutations in the tau gene in Pallido-Ponto-Nigral degeneration and related chromosome 17-linked neurodegenerative disorders. Proc. Natl. Acad. Sci. USA 95, 13103-13107
• Poorkaj, P., Bird, T. D., Wijsman, E. M., Nemens, E, Garruto, R., M., Anderson, L., Andreadis, A., Wiederholt W. C., , Raskind, M., and Schellenberg, G. D. (1998) Tau is a Candidate Gene for Chromosome 17 Frontotemporal Dementia. Ann. Neurol.43, 815-825.
• Yu, C.-E., Oshima, J., Fu, Y.-H., Wijsman, E. M., Hisima, F., Alisch, R., Matthews, S., Nakura, J., Miki, T., Ouais, S., Martin, G. M., Mulligan, J., Schellenberg, G. D. (1996) Positional cloning of the gene for the Werner's syndrome locus. Science 272:258-262
• Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, Chang-en, Jondro, P. D., Schmidt, S., D., Wang, K., Crowley, A. C., Fu, Y.-H., Guenette, S. Y., Galas, D., Nemens, E., Wijsman, E. M., Bird, T. D., Schellenberg, G. D., Tanzi, R. E. (1995) Candidate gene for chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.
• Levy-Lahad, E.,Wijsman, E. M., Nemens, E., Anderson, L, Goddard, K. A. B., Weber, J. L., Bird, T. D., Schellenberg, G. D. (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269:970-973.
• Schellenberg, G.D., Bird, T.D., Wijsman, E.M., Orr, H.T., Anderson, L., Nemens, E., White, J.A., Bonnycastle, L., Weber, J.L., Alonso, E., Potter, H., Heston, L.L. and Martin, G.M. (1992) Genetic Linkage Evidence for a Familial Alzheimer Disease Locus on Chromosome 14. Science 258:668-671.
• Schellenberg, G.D., Boehnke, M., Wijsman, E.M., Moore, D.K., Martin, G.M., Bird, T.D. (1992) Genetic Association and Linkage Analysis of the Apo CII Locus and Familial Alzheimer's Disease. Ann. Neurol. 31:223-227.
• Schellenberg, G.D., Bird, T.D., Wijsman, E.M., Moore, D.K., Boehnke, M., Bryant, E.M., Lampe, T.H., Nochlin, D., Sumi, S.M., Deeb, S.M., Beyreuther, K., and Martin, G.M. (1988) Absence of Linkage of Chromosome 21 q21 Markers to Familial Alzheimer's Disease in Autopsy Documented Pedigrees. Science 241:1507-1509.
• Schellenberg, G.D, Deeb, S.S., Boehnke, M.L., Bryant, E.M., Martin, G.M., Lampe, T.H., and Bird, T.D. (1987) Association of an Apolipoprotein CII Allele with Familial Dementia of the Alzheimer Type. J. Neurogenet. 4:97 108.