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Charles Wilkinson, Ph.D.

Position: Research Associate Professor

Qualifications:

• B.S., Zoology, Psychology, University of Michigan, Ann Arbor, 1969
• Ph.D., Psychology (Physiological), University of California, Santa Barbara, 1977
• Postdoc, Physiology, University of California, San Francisco, 1977-80
• Postdoc, Endocrinology, Mt. Sinai School of Medicine of City Univ. of New York, 1981

Past Positions:

• 1991- Research Associate Professor in Psychiatry and Behavioral Sciences, University of Washington
• 1984- Research Physiologist, VA Puget Sound Health Care System, Tacoma and Seattle, WA
• 1984-1991 Research Assistant Professor in Psychiatry and Behavioral Sciences, University of Washington
• 1982-1984 Research Physiologist, Seattle VA Medical Center, Seattle, WA
• 1982 Instructor in Pharmacology, Mount Sinai School of Medicine of CUNY
• 1981 Postdoctoral Fellow in Endocrinology, Mount Sinai School of Medicine of CUNY
• 1980 Lecturer in Biology, University of California, Santa Cruz
• 1977-1980 Postdoctoral Fellow in Physiology, University of California, San Francisco

Selected Publications:

• Evans SB, Wilkinson CW, Gronbeck P, Bennett JL, Zavosh A, Taborsky GJ Jr, Figlewicz DP: Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia. Am J Physiol Regul Integr Comp Physiol 286:R123-R128, 2004.
• Evans SB, Wilkinson CW, Gronbeck P, Bennett JL, Taborsky GJ Jr, Figlewicz DP: Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failure. Am J Physiol Regul Integr Comp Physiol 284:R57-R65, 2003.
• Figlewicz DP, Van Dijk G, Wilkinson CW, Gronbeck P, Higgins M, Zavosh A: Effects of repetitive hypoglycemia on neuroendocrine response and brain tyrosine hydroxylase activity in the rat. Stress 5:207-226, 2002.
• Lupien SJ, Wilkinson CW, Briere S, Ng Ying Kin NM, Meaney MJ, Nair NP: Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids. J Clin Endocrinol Metab 87:3798-3807, 2002.
• Ashman SB, Dawson G, Panagiotides H, Yamada E, Wilkinson CW: Stress hormone levels of children of depressed mothers. Dev Psychopathol 14:333-349, 2002
• Rasmussen DD, Boldt BM, Wilkinson CW, Mitton DR: Chronic daily ethanol and withdrawal: 3. Forebrain pro-opiomelanocortin gene expression and implications for dependence, relapse, and deprivation effect. Alcohol Clin Exp Res 26:535-546, 2002.
• Lupien SJ, Wilkinson CW, Bri?re S, Ménard C, Ng Ying Kin NMK, Nair NPV: The modulatory effects of corticosteroids on cognition: studies in young human populations. Psychoneuroendocrinology 27:401-416, 2002.
• Evans SB, Wilkinson CW, Bentson K, Gronbeck P, Zavosh A, Figlewicz DP: PVN activation is suppressed by repeated hypoglycemia but not antecedent corticosterone in the rat. Am J Physiol Regul Integr Comp Physiol 281:R1426-R1436, 2001.
• Kanter ED, Wilkinson CW, Radant AD, Petrie EC, Dobie DJ, McFall ME, Peskind ER, Raskind MA: Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Biol Psychiatry 50:238-245, 2001.
• Clark AF, Steely HT, Dickerson JE Jr, English-Wright S, Stropki K, McCartney MD, Jacobson N, Shepard AR, Clark JI, Matsushima H, Peskind ER, Leverenz JB, Wilkinson CW, Swiderski RE, Fingert JH, Sheffield VC, Stone EM: Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues. Invest Ophthalmol Vis Sci 42:1769-1780, 2001.
• Peskind ER, Wilkinson CW, Petrie EC, Schellenberg GD, Raskind MA: Increased CSF cortisol in AD is a function of APOE genotype. Neurology 56:1094-1098, 2001.
• Prinz P, Bailey S, Moe K, Wilkinson C, Scanlan J: Urinary free cortisol and sleep under baseline and stressed conditions in healthy senior women: effects of estrogen replacement therapy. J Sleep Res 10:19-26, 2001.
• Seeman TE, Singer B, Wilkinson CW, McEwen, BS: Gender differences in age-related changes in HPA axis reactivity. Psychoneuroendocrinology 26:225-240, 2001.
• Wilkinson CW, Petrie EC, Murray SR, Colasurdo EA, Raskind MA, Peskind ER: Human glucocorticoid feedback inhibition is reduced in older individuals: evening study. J Clin Endocrinol Metab 86:545-550, 2001.
• Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW: Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 24:1836-1849, 2000.
• Mystkowski P, Seeley RJ, Hahn TM, Baskin DG, Havel PJ, Matsumoto AM, Wilkinson CW, Peacock-Kinzig K, Blake KA, Schwartz MW: Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss. J Neurosci 20:8637-8642, 2000.
• McMinn JE, Wilkinson CW, Havel PJ, Woods SC, Schwartz MW: Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. Am J Physiol 279:R695-R703, 2000.
• Pascualy M, Petrie EC, Brodkin K, Peskind ER, Wilkinson CW, Raskind MA: Hypothalamic pituitary adrenocortical and sympathetic nervous system responses to the cold pressor test in Alzheimer's disease. Biol Psychiatry 48:247-254, 2000.
• Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD: Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 141:487-497, 2000.
• Craft S, Asthana S, Newcomer JW, Wilkinson CW, Matos IT, Baker LD, Cherrier M, Lofgreen C, Latendresse S, Petrova A, Plymate S, Raskind M, Grimwood K, Veith RC: Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. Arch Gen Psychiatry 56:1135-1140, 1999.
• McCann BS, Benjamin GA, Wilkinson CW, Retzlaff BM, Russo J, Knopp RH: Plasma lipid concentrations during episodic occupational stress. Ann Behav Med 21:103-110, 1999.
• Dukoff R, Wilkinson CW, Lasser R, Friz J, Conway A, Bahro M, Peskind ER, Sunderland T: Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers. Biol Psychiatry 46:189-195, 1999.
• Sindelar DK, Havel PJ, Seeley RJ, Wilkinson CW, Woods SC, Schwartz MW: Low plasma leptin levels contribute to diabetic hyperphagia in rats. Diabetes 48:1275-1280, 1999.
• Petrie EC, Wilkinson CW, Murray S, Jensen C, Peskind ER, Raskind MA: Effects of Alzheimer's disease and gender on the hypothalamic-pituitary-adrenal axis response to lumbar puncture stress. Psychoneuroendocrinology 24:385-395, 1999.
• van Dijk G, Seeley RJ, Thiele TE, Friedman MI, Ji H, Wilkinson CW, Burn P, Campfield LA, Tenenbaum R, Baskin DG, Woods SC, Schwartz MW: Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am J Physiol 276:R1425-R1433, 1999
• Leverenz JB, Wilkinson CW, Wamble M, Corbin S, Grabber JE, Raskind MA, Peskind ER: Effect of chronic high-dose exogenous cortisol on hippocampal neuronal number in aged nonhuman primates. J Neurosci 19:2356-2361, 1999.
• Rasmussen DD, Boldt BM, Wilkinson CW, Yellon SM, Matsumoto AM: Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 140:1009-1012, 1999.
• Peskind ER, Jensen CF, Pascualy M, Tsuang D, Cowley D, Martin DC, Wilkinson CW, Raskind MA: Sodium lactate and hypertonic sodium choride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder. Biol Psychiatry 44:1007-1016, 1998.
• McMinn JE, Seeley RJ, Wilkinson CW, Havel PJ, Woods SC, Schwartz MW: NPY-induced overfeeding suppresses hypothalamic NPY mRNA expression: potential roles of plasma insulin and leptin. Regul Pept 75-76:425-431, 1998.
• Rasmussen DD, Bryant CA, Boldt BM, Colasurdo EA, Levin N, Wilkinson CW: Acute alcohol effects on opiomelanocortinergic regulation. Alcohol Clin Exp Res 22:789-801, 1998.
• van Dijk G, Donahey JCK, Thiele TE, Scheruink AJW, Steffens AB, Wilkinson CW, Tenenbaum R, Campfield LA, Burn P, Seeley RJ, Woods SC: Central leptin stimulates corticosterone secretion at the onset of the dark phase. Diabetes 46:1911-1914, 1997.
• Chavez M, Seeley RJ, Green PK, Wilkinson CW, Schwartz MW, Woods SC: Adrenalectomy increase sensitivity to central insulin. Physiol Behav 62:631-634, 1997.