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George M. Martin, M.D.

Position: Professor Emeritus
Appointed: 1968

Qualifications:

• B.S., University of Washington, Chemistry, 1948
• M.D., University of Washington, Medicine, 1953
• Internship, Montreal General Hospital, Med., Surg., Gyn., 1954
• Residency, University of Chicago, Anatomic Pathology, 1957

Past Positions:

• 1985-1999, University of Washington, Alzheimer's Disease Research Center, Director
• 1975-present, University of Washington, Dept. of Genetics, Adjunct Professor
• 1980-1981, University of Washington, Dept. of Pathology, Acting Chairman
• 1970-1973, University of Washington, Medical Scientist Training Program, Founding Director
• 1964-1968, University Hospital, Director of Cytogenetics Laboratory
• 1961-1962, Glasgow University, Genetics Dept., Senior Fellow
• 1957-Instructor to Professor (1968) to Emeritus Active (2003) Pathology, University of Washington, Seattle
• 1956-1957, University of Chicago, Instructor in Pathology

Honors and Awards:

• 2001, IPSEN Foundation Longevity Prize
• 2000, Lifetime Achievement Award, World Alzheimer Congress
• 1998, Distinguished Scientist Award, University of Urbino, Faculty of Sciences, Urbino, Italy
• 1998, Paul Glenn Foundation Award
• 1998, Paul Harris Fellow, Rotary International
• 1996, Irving Wright Award of Distinction of the American Federation for Aging Research
• 1993, Robert W. Kleemeier Award, Gerontological Society of America
• 1992, Research Medal, American Aging Association
• 1992, Member, Institute of Medicine, National Academy of Sciences
• 1991, Humboldt Distinguished Scientist Award, Dept. Human Genetics, Univ. Wurzburg, Germany

Selected Publications:

• Wang B, Hu Q, Hearn MG, Shimizu K, Ware CB, Liggitt DH, Jin LW, Cool BH, Storm DR, Martin GM. Isoform-specific knockout of FE65 leads to impaired learning and memory. J Neurosci Res. 75:12-24, 2004.
• Martin, G.M. The Evolutionary Substrate of Aging. Archives of Neurology 59: 1702-1705, 2003.
• Martin, G.M. Genetic Modulation of Aging and Longevity. In The Genetic Basis of Common Disease, 2nd Edition, Edited by RA King, JI Rotter, AG Motulsky, pp. 964-974, Oxford University Press, New York, 2002.
• Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci 19:57-61, 2002.
• Martin, G.M. and Zitnik, G. Age-related Decline in Neurogenesis: Old Cells or Old Environment? Journal of Neuroscience Research 70:258-263, 2002.
• Martin, G.M. Gene Action in the Aging Brain: An Evolutionary Biological Perspective. Neurobiol Aging 23:47, 2002.
• Hu, Q., Cool, B.H., Wang, B., Hearn, M.G., and Martin, G.M. A Candidate Molecular Mechanism for the Association of an Intronic Polymorphism of FE65 with Resistance to Very-Late Onset Dementia of the Alzheimer Type. Human Molecular Genetics 11: 465-475, 2002.
• Martin, G.M. Gene Action in the Aging Brain: An Evolutionary Biological Perspective. Neurobiol Aging, 23:647-654, 2002.
• Hu, Q., Cool, B.H., Wang, B., Hearn, M.G., and Martin, G.M. A Candidate Molecular Mechanism for the Association of an Intronic Polymorphism of FE65 with Resistance to Very-Late Onset Dementia of the Alzheimer Type. Human Molecular Genetics. 11: 465-475, 2002.
• Martin, G.M. Keynote: Mechanisms of senescence - complificationists versus simplificationists. Mechanisms of Ageing and Development. 123: 65-73, 2002.
• Ogburn CE, Carlberg K, Ottinger MA, Holmes DJ, Martin GM, Austad SN. Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. Journals of Gerontology Series A - Biological Sciences and Medical Sciences. 56 (11): B468-B474 Nov 2001.
• Feng, R., Rampon, C., Tang, Y., Shrom, D., Jin, J., Kyin, M., Sopher, B., Martin, G.M., Kim, S., Langdon, R.B., Sisodia, S.S., and Tsien, J.Z., Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice is Associated with Reduced Clearance of Hippocampal Memory Traces. Neuron. 32: 911-926, 2001.
• Martin, G.M. Frontiers of Aging. In: Science 294:13, 2001
• Hadley, E.C., Rossi, W.K., Albert, S.M., Bailey-Wilson, J., Baron, J., Cawthon, R., Christian, J.C., Corder, E.H., Franceschi, C., Kestenbaum, B., Kruglyak, L., Lauderdale, D.S., Lubitz, J., Martin, G.M., McClearn, G.E., McGue, M., Miles, T., Mineau, G., Ouellette, G., Pedersen, N.L., Preston, S.H., Page, W.F., Province, M., Schächter, F., Schork, N.J., Vaupel, J.W., Vijg, J., Wallace, R., Wang, E., and Wijsman, E.M. Genetic epidemiologic studies on age-specified traits. Am J Epidemiol 152:1003-1008, 2000.
• Martin, G.M., and Oshima, J. Lessons from human progeroid syndromes. Nature 408:263-266, 2000.
• Martin, G.M. Molecular mechanisms of late-life dementias. Exp Gerontol 35:439-443, 2000.
• Martin, G.M. Some new directions for research on the biology of aging. Review. Ann NY Acad Sci. 908:1-13, 2000.
• Hu, Q.B., Jin, L.W., Starbuck, M.Y., and Martin, G.M. Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions. J Neurosci Res 60:73-86, 2000.
• Martin, G.M. APOE alleles and lipophylic pathogens. Neurobiol Aging 20:441-443, 1999.
• Martin, G.M. Emerging paradigms and new perspectives for human geneticists interested in the biology of aging. AGE 22:132, 1999.
• Martin, G.M. Genes that modulate longevity and senescence. In: Paradoxes of Longevity. Foundation Ipsen, World Health Organization, 1999.
• Guo, Q., Sebastian, L., Sopher, B.L., Miller, M.W., Glazner, G.W., Ware, C.B., Martin, G.M., and Mattson, M.P. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci USA 96:4125-4130, 1999.
• Guo, Q., Sebastian, L., Sopher, B.L., Miller, M.W., Ware, C.B., Martin, G.M., and Mattson, M.P. Increased vulnerability of hippocampal neurons from presenilin-1 mutuant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem 72:1019-1029, 1999.
• Guo, Q., Fu, W., Sopher, B., Miller, M.W., Ware, C.B., Martin, G.M., Mattson, M.P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 5:101-106, 1999.
• Kirkwood, T.B.L., Martin, G.M., Partridge, L., Chapter: Evolution, Senescence, and Health in Old Age. In: Evolution of Health and Disease, 1998.
• Ogburn, C.E., Austad, S.N., Holmes, D.J., Kiklevich, J.V., Gollahon, K., Raninovitch, P.S., Martin, G.M. Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage. JGerontology, 1998.
• Kukull, W.A. and Martin, G.M. APOE Polymorphisms and Late-Onset Alzheimer Disease: The Importance of Ethnicity. J Am Med Assoc. 1998
• Martin, G.M. and Wang, E. Aging and longevity: towards the next millenium. Molecular Medicine Today 4(4):145, 1998.
• Yu, C-E., Oshima, J., Wijsman, E.M., Nakura, J., Miki, T., Puissan, C., Matthews, S., Fu, Y-H., Mulligan, J., Martin, G.M., Schellenberg, G.D., and the Werner's Syndrome Collaborative Group. Mutations in the consensus helicase domains of the Werner's syndrome gene. Am. J. Hum. Gnet., 60:330-341, 1997.
• Guo, Q., Sopher, B.L., Furukawa, K. Pham, D.G., Robinson, N., Martin, G.M., and Mattson, M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid B-peptide: involvement of calcium and oxyradicals. Jneuroscience. 17(11):4212-4222, June1, 1997.
• Gray, M.D., Shen, J.D., Kamath-Loeb, A.S., Blank, A., Sopher, B.L., Martin, G.M., Oshima, J., Loeb, L.A. The Werner syndrome protein is a DNA helicase. NatureGenetics, 17:100-103, September 1997.
• Walker, K.A., Jennings, C.D., Pulliam, J., Ogburn, C., Martin, G.M., Urano, M., and Turker, M.S. A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and mutator phenotype for loss of heterozygosity events. Somatic Cell and Mol. Gen., 23:111-121, 1997.
• Ogburn, C.E., Oshima, J., Poot, M., Chen, R., Hunt, K.E., Gollahon, K.A., Rabinovitch, P.S., and Martin, G.M. An apoptosis-inducing genotixin differntiates heterozygotic carriers for Werner helicase mutations from wild type and homozygous mutants. Human Genetics. 101:121-125, 1997.
• Martin, G.M. and Mian S.I. New Mice for Old Questions. Nature. 390:18-19, November, 1997.
• Martin, G.M. Genetics and the pathobiology of aging. Phil. Trans.R.Soc.Lond.B 352:1773-1780, 1997.
• Hearn, M.G., Edland, S.D., Ogburn, C.E., Smith, A.C., Bird, T.D., Martin, G.M., & Fukuchi, K. Trypsin inhibitor activites of fibroblasts increase with age of donor and are unaltered in familial Alzheimer's disease, Exp. Gerontol. 29:611-623, 1994.
• Fukuchi, K., Kunkel, D.D., Schwartkroin, P.A., Kamino, K., Ogburn, C.E., Furlong, C.E., & Martin, G.M. Overexpression of a COOH-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells. Exp. Neurol., 127: 253-264, 1994.
• Chang, M., Burmer, G.C., Sweasy, J., Loeb, L.A., Edelhoff, S., Disteche, C.M., Yu, C.E., Anderson, L., Oshima, J., Nakura, J., Miki, T., Kamino, K., Ogihara, T., Schellenberg, G.D. & Martin, G.M. Evidence against DNA polymerase beta as a candidate gene for the Werner syndrome. Hum. Genet., 93(5): 507-512, 1994.
• Wijsman, E.M., Bird, T.D., Martin, G.M. & Schellenberg, G.D. The Seattle Alzheimer's disease data set. Genet. Epidemiol., 10: 365-369, 1993.
• Martin, G.M. Abiotrophic gene action in Homo sapiens: Potential mechanisms and significance for the pathobiology of aging. Genetica, 91: 265-277, 1993.